Upregulating hsa-miR-128a Increased the Effects of Pembrolizumab on Laryngeal Cancer Cells via the p53 Pathway

Objectives. Recently, immunotherapy and microRNA have shown much more promises in oncology research, inspiring new hope for a cure for various malignancies. Specifically, the function and mechanisms of action of pembrolizumab have been investigated in many cancers, but not in laryngeal squamous cell...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	BioMed research international 2021, Vol.2021, p.2342784-6
Hauptverfasser:	Chen, Hui, Guo, Yang, Huang, Jiameng, Zhou, Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antibodies Antibodies, Monoclonal, Humanized - pharmacology Assaying Biotechnology Bmi protein Cancer Cancer cells Cancer therapies Cell Line, Tumor Cellular signal transduction Chemotherapy Drug therapy Enzymes Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Health aspects Humans Identification and classification Immunotherapy Laryngeal cancer Laryngeal Neoplasms - drug therapy Laryngeal Neoplasms - genetics Laryngeal Neoplasms - metabolism Laryngeal Neoplasms - pathology Medical prognosis Medical research Metastasis MicroRNA MicroRNAs - biosynthesis MicroRNAs - genetics miRNA Monoclonal antibodies p53 Protein Patient outcomes Pembrolizumab Physiological aspects Plasmids Polymerase chain reaction Properties Ribonucleic acid RNA RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics Sensitivity analysis Signal Transduction - drug effects Squamous cell carcinoma Targeted cancer therapy Tumor cell lines Tumor proteins Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Up-Regulation - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!