Pegylated Recombinant Human Arginase 1 Induces Autophagy and Apoptosis via the ROS-Activated AKT/mTOR Pathway in Bladder Cancer Cells

Bladder cancer is one of the most commonly diagnosed cancers worldwide, especially in males. Current therapeutic interventions, including surgery, radiation therapy, chemotherapy, and immunotherapy, have not been able to improve the clinical outcome of bladder cancer patients with satisfaction. Reco...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.5510663-5510663
Hauptverfasser:	Zhao, Zhuyun, Zhang, Peng, Li, Wei, Wang, Dengchuan, Ke, Changneng, Liu, Yueming, Ho, James Chung-Man, Cheng, Paul Ning-Man, Xu, Shi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Animals Antibodies Apoptosis Apoptosis - drug effects Arginase - pharmacology Arginine - metabolism Autophagy - drug effects Biotechnology Bladder cancer Cancer therapies Cell Line, Tumor Chemotherapy Female Flow cytometry Fluorides Humans Immunotherapy Lung cancer Membrane Potential, Mitochondrial - drug effects Metabolism Mice Mice, Inbred BALB C Mice, Nude Mitochondria - drug effects Mitochondria - metabolism Neoplasm Proteins - metabolism Polyamines Proteins Proto-Oncogene Proteins c-akt - metabolism Reactive Oxygen Species - metabolism Recombinant Proteins - pharmacology Signal Transduction TOR Serine-Threonine Kinases - metabolism Urinary Bladder Neoplasms - enzymology Urinary Bladder Neoplasms - pathology Xenograft Model Antitumor Assays
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