Effects of Mesenchymal Stem Cell‐Derived Paracrine Signals and Their Delivery Strategies
Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for tissue regeneration and remodeling due to their potent bioactivity, which includes modulation of inflammation response, macrophage polarization toward proregenerative lineage, promotion of angiogenesis, and reducti...
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| Veröffentlicht in: | Advanced healthcare materials 2021-04, Vol.10 (7), p.e2001689-n/a |
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| creator | Chang, Calvin Yan, Jerry Yao, Zhicheng Zhang, Chi Li, Xiaowei Mao, Hai‐Quan |
| description | Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for tissue regeneration and remodeling due to their potent bioactivity, which includes modulation of inflammation response, macrophage polarization toward proregenerative lineage, promotion of angiogenesis, and reduction in fibrosis. This review focuses on profiling the effects of paracrine signals of MSCs, commonly referred to as the secretome, and highlighting the various engineering approaches to tune the MSC secretome. Recent advances in biomaterials‐based therapeutic strategies for delivery of MSCs and MSC‐derived secretome in the form of extracellular vesicles are discussed, along with their advantages and challenges.
This review discusses various engineering approaches to tune the effects of paracrine signals secreted by mesenchymal stem cells (MSCs), commonly referred to as the secretome. Recent advances in biomaterials‐based therapeutic strategies for delivery of MSCs and MSC‐derived secretome in the form of extracellular vesicles are discussed along with their advantages and challenges. |
| doi_str_mv | 10.1002/adhm.202001689 |
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This review discusses various engineering approaches to tune the effects of paracrine signals secreted by mesenchymal stem cells (MSCs), commonly referred to as the secretome. Recent advances in biomaterials‐based therapeutic strategies for delivery of MSCs and MSC‐derived secretome in the form of extracellular vesicles are discussed along with their advantages and challenges.</description><identifier>ISSN: 2192-2640</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.202001689</identifier><identifier>PMID: 33433956</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Angiogenesis ; Biological activity ; Biomaterials ; Biomedical materials ; Extracellular Vesicles ; Fibrosis ; Humans ; Inflammation ; Macrophages ; Mesenchymal Stem Cells ; microRNA ; Paracrine Communication ; paracrine signaling ; Paracrine signalling ; Regeneration ; Review ; Reviews ; Secretome ; Stem cells ; Tissue engineering ; Wound Healing</subject><ispartof>Advanced healthcare materials, 2021-04, Vol.10 (7), p.e2001689-n/a</ispartof><rights>2021 Wiley‐VCH GmbH</rights><rights>2021 Wiley-VCH GmbH.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5339-c1312798e2bb0bb83add4bbf527e90ec3aba770b2c404036ac7c6c514079c16f3</citedby><cites>FETCH-LOGICAL-c5339-c1312798e2bb0bb83add4bbf527e90ec3aba770b2c404036ac7c6c514079c16f3</cites><orcidid>0000-0001-9755-8673 ; 0000-0001-8201-3953 ; 0000-0003-0714-1140 ; 0000-0002-4262-9988 ; 0000-0001-8278-1354</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadhm.202001689$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadhm.202001689$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,777,781,882,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33433956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Calvin</creatorcontrib><creatorcontrib>Yan, Jerry</creatorcontrib><creatorcontrib>Yao, Zhicheng</creatorcontrib><creatorcontrib>Zhang, Chi</creatorcontrib><creatorcontrib>Li, Xiaowei</creatorcontrib><creatorcontrib>Mao, Hai‐Quan</creatorcontrib><title>Effects of Mesenchymal Stem Cell‐Derived Paracrine Signals and Their Delivery Strategies</title><title>Advanced healthcare materials</title><addtitle>Adv Healthc Mater</addtitle><description>Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for tissue regeneration and remodeling due to their potent bioactivity, which includes modulation of inflammation response, macrophage polarization toward proregenerative lineage, promotion of angiogenesis, and reduction in fibrosis. This review focuses on profiling the effects of paracrine signals of MSCs, commonly referred to as the secretome, and highlighting the various engineering approaches to tune the MSC secretome. Recent advances in biomaterials‐based therapeutic strategies for delivery of MSCs and MSC‐derived secretome in the form of extracellular vesicles are discussed, along with their advantages and challenges.
This review discusses various engineering approaches to tune the effects of paracrine signals secreted by mesenchymal stem cells (MSCs), commonly referred to as the secretome. 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This review discusses various engineering approaches to tune the effects of paracrine signals secreted by mesenchymal stem cells (MSCs), commonly referred to as the secretome. Recent advances in biomaterials‐based therapeutic strategies for delivery of MSCs and MSC‐derived secretome in the form of extracellular vesicles are discussed along with their advantages and challenges.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33433956</pmid><doi>10.1002/adhm.202001689</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0001-9755-8673</orcidid><orcidid>https://orcid.org/0000-0001-8201-3953</orcidid><orcidid>https://orcid.org/0000-0003-0714-1140</orcidid><orcidid>https://orcid.org/0000-0002-4262-9988</orcidid><orcidid>https://orcid.org/0000-0001-8278-1354</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Angiogenesis Biological activity Biomaterials Biomedical materials Extracellular Vesicles Fibrosis Humans Inflammation Macrophages Mesenchymal Stem Cells microRNA Paracrine Communication paracrine signaling Paracrine signalling Regeneration Review Reviews Secretome Stem cells Tissue engineering Wound Healing |
| title | Effects of Mesenchymal Stem Cell‐Derived Paracrine Signals and Their Delivery Strategies |
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