Phase I trial of convection-enhanced delivery of IL13RA2 and EPHA2 receptor targeted cytotoxins in dogs with spontaneous intracranial gliomas

Abstract Background The interleukin-13 receptor alpha 2 (IL13RA2) and ephrin type A receptor 2 (EPHA2) are attractive therapeutic targets, being expressed in ~90% of canine and human gliomas, and absent in normal brain. Clinical trials using an earlier generation IL-13 based cytotoxin showed encoura...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2021-03, Vol.23 (3), p.422-434
Hauptverfasser:	Rossmeisl, John H, Herpai, Denise, Quigley, Mindy, Cecere, Thomas E, Robertson, John L, D’Agostino, Ralph B, Hinckley, Jonathan, Tatter, Stephen B, Dickinson, Peter J, Debinski, Waldemar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic and Translational Investigations Brain Neoplasms - drug therapy Convection Cytotoxins - therapeutic use Dogs Drug Delivery Systems Glioma - drug therapy Receptor, EphA2
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!