Expression profiles of metallothionein-I/II and megalin/LRP-2 in uterine cervical squamous lesions
Metallothioneins (MTs) are phylogenetically old cysteine-rich proteins, which are implicated in a variety of physiological and pathological processes. Their growth-regulating, anti-apoptotic and anti-inflammatory functions have been attributed not only to intracellular free radical scavenging and to...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2021-04, Vol.478 (4), p.735-746 |
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| creator | Jakovac, Hrvoje Stašić, Nikola Krašević, Maja Jonjić, Nives Radošević-Stašić, Biserka |
| description | Metallothioneins (MTs) are phylogenetically old cysteine-rich proteins, which are implicated in a variety of physiological and pathological processes. Their growth-regulating, anti-apoptotic and anti-inflammatory functions have been attributed not only to intracellular free radical scavenging and to zinc and copper regulation but also to the ability of secreted MT to bind on surface lipoprotein receptor-megalin/LRP2, which enables the endocytosis of MT-I/II and a wide range of other functionally distinct ligands. In the present study, we analysed the expression pattern of both proteins in 55 cases of premalignant transformation of cervical squamous cells, i.e. in low- and high-grade squamous intraepithelial lesion (LSIL and HSIL). The data showed that in LSIL (cervical intraepithelial neoplasia CIN1;
N
= 25) MTs were present only in basal and parabasal cells and that megalin was only weakly expressed. In HSIL (CIN2;
N
= 15 and CIN 3/carcinoma in situ;
N
= 15), however, overexpression and co-localization of MT with megalin were found in the entire hyperplastic epithelium. Moreover, megalin immunoreactivity appeared on the glandular epithelium and vascular endothelium, as well as on lymphatic cells in stroma. Besides, multiple megalin-positive cells expressed phosphorylated Akt1, implying that MT- and/or megalin-dependent prosurvival signal transduction pathways might contribute to the development of severe cervical dysplasia. The data emphasize the diagnostic power of combined MT/megalin analysis in pre-cancer screening. |
| doi_str_mv | 10.1007/s00428-020-02947-w |
| format | Article |
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N
= 25) MTs were present only in basal and parabasal cells and that megalin was only weakly expressed. In HSIL (CIN2;
N
= 15 and CIN 3/carcinoma in situ;
N
= 15), however, overexpression and co-localization of MT with megalin were found in the entire hyperplastic epithelium. Moreover, megalin immunoreactivity appeared on the glandular epithelium and vascular endothelium, as well as on lymphatic cells in stroma. Besides, multiple megalin-positive cells expressed phosphorylated Akt1, implying that MT- and/or megalin-dependent prosurvival signal transduction pathways might contribute to the development of severe cervical dysplasia. The data emphasize the diagnostic power of combined MT/megalin analysis in pre-cancer screening.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-020-02947-w</identifier><identifier>PMID: 33084977</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>AKT1 protein ; Apoptosis ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Cancer ; Cancer screening ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Cervical cancer ; Cervical Intraepithelial Neoplasia - diagnosis ; Cervical Intraepithelial Neoplasia - genetics ; Cervical Intraepithelial Neoplasia - metabolism ; Cervical Intraepithelial Neoplasia - pathology ; Cervix ; Dysplasia ; Early Detection of Cancer ; Endocytosis ; Endothelium ; Epithelium ; Female ; Free radicals ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Human papillomavirus ; Humans ; Immunohistochemistry ; Immunoreactivity ; Inflammation ; Lesions ; Localization ; Low Density Lipoprotein Receptor-Related Protein-2 - genetics ; Low Density Lipoprotein Receptor-Related Protein-2 - metabolism ; LRP2 protein ; Medical screening ; Medicine ; Medicine & Public Health ; Metallothionein ; Metallothionein - genetics ; Metallothionein - metabolism ; Metallothioneins ; Original ; Original Article ; Pathology ; Pattern analysis ; Phylogeny ; Proteins ; Scavenging ; Signal transduction ; Squamous cells ; Stroma ; Transcriptome ; Tumor Microenvironment ; Uterine Cervical Neoplasms - diagnosis ; Uterine Cervical Neoplasms - genetics ; Uterine Cervical Neoplasms - metabolism ; Uterine Cervical Neoplasms - pathology ; Uterus</subject><ispartof>Virchows Archiv : an international journal of pathology, 2021-04, Vol.478 (4), p.735-746</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-f0a3bdfa02dbe8c2905ad5c10d040f2740d770de93ba69cf808b96878685bf923</citedby><cites>FETCH-LOGICAL-c474t-f0a3bdfa02dbe8c2905ad5c10d040f2740d770de93ba69cf808b96878685bf923</cites><orcidid>0000-0002-3331-9320 ; 0000-0003-2995-0766 ; 0000-0001-8174-5124</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00428-020-02947-w$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00428-020-02947-w$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33084977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jakovac, Hrvoje</creatorcontrib><creatorcontrib>Stašić, Nikola</creatorcontrib><creatorcontrib>Krašević, Maja</creatorcontrib><creatorcontrib>Jonjić, Nives</creatorcontrib><creatorcontrib>Radošević-Stašić, Biserka</creatorcontrib><title>Expression profiles of metallothionein-I/II and megalin/LRP-2 in uterine cervical squamous lesions</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><addtitle>Virchows Arch</addtitle><description>Metallothioneins (MTs) are phylogenetically old cysteine-rich proteins, which are implicated in a variety of physiological and pathological processes. Their growth-regulating, anti-apoptotic and anti-inflammatory functions have been attributed not only to intracellular free radical scavenging and to zinc and copper regulation but also to the ability of secreted MT to bind on surface lipoprotein receptor-megalin/LRP2, which enables the endocytosis of MT-I/II and a wide range of other functionally distinct ligands. In the present study, we analysed the expression pattern of both proteins in 55 cases of premalignant transformation of cervical squamous cells, i.e. in low- and high-grade squamous intraepithelial lesion (LSIL and HSIL). The data showed that in LSIL (cervical intraepithelial neoplasia CIN1;
N
= 25) MTs were present only in basal and parabasal cells and that megalin was only weakly expressed. In HSIL (CIN2;
N
= 15 and CIN 3/carcinoma in situ;
N
= 15), however, overexpression and co-localization of MT with megalin were found in the entire hyperplastic epithelium. Moreover, megalin immunoreactivity appeared on the glandular epithelium and vascular endothelium, as well as on lymphatic cells in stroma. Besides, multiple megalin-positive cells expressed phosphorylated Akt1, implying that MT- and/or megalin-dependent prosurvival signal transduction pathways might contribute to the development of severe cervical dysplasia. The data emphasize the diagnostic power of combined MT/megalin analysis in pre-cancer screening.</description><subject>AKT1 protein</subject><subject>Apoptosis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cancer</subject><subject>Cancer screening</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cervical cancer</subject><subject>Cervical Intraepithelial Neoplasia - diagnosis</subject><subject>Cervical Intraepithelial Neoplasia - genetics</subject><subject>Cervical Intraepithelial Neoplasia - metabolism</subject><subject>Cervical Intraepithelial Neoplasia - pathology</subject><subject>Cervix</subject><subject>Dysplasia</subject><subject>Early Detection of Cancer</subject><subject>Endocytosis</subject><subject>Endothelium</subject><subject>Epithelium</subject><subject>Female</subject><subject>Free radicals</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunoreactivity</subject><subject>Inflammation</subject><subject>Lesions</subject><subject>Localization</subject><subject>Low Density Lipoprotein Receptor-Related Protein-2 - genetics</subject><subject>Low Density Lipoprotein Receptor-Related Protein-2 - metabolism</subject><subject>LRP2 protein</subject><subject>Medical screening</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metallothionein</subject><subject>Metallothionein - genetics</subject><subject>Metallothionein - metabolism</subject><subject>Metallothioneins</subject><subject>Original</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Pattern analysis</subject><subject>Phylogeny</subject><subject>Proteins</subject><subject>Scavenging</subject><subject>Signal transduction</subject><subject>Squamous cells</subject><subject>Stroma</subject><subject>Transcriptome</subject><subject>Tumor Microenvironment</subject><subject>Uterine Cervical Neoplasms - diagnosis</subject><subject>Uterine Cervical Neoplasms - genetics</subject><subject>Uterine Cervical Neoplasms - metabolism</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterus</subject><issn>0945-6317</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtv1DAUhS1ERYfCH2CBIrFhY-b6kdjeIKGqwEgjtapgbTmOPXWV2FM7acu_xzClPBYsLC_Od47v9UHoFYF3BECsCwCnEgOFehQX-O4JWhHOKKYMxFO0AsVb3DEijtHzUq4BKJGke4aOGQPJlRAr1J_d77MrJaTY7HPyYXSlSb6Z3GzGMc1XVXAh4s16s2lMHKqwM2OI6-3lBaZNiM0yuxyia6zLt8GasSk3i5nSUpoaVd3lBTryZizu5cN9gr5-PPty-hlvzz9tTj9sseWCz9iDYf3gDdChd9JSBa0ZWktgAA6eCg6DEDA4xXrTKeslyF51UshOtr1XlJ2g94fc_dJPbrAuztmMep_DZPI3nUzQfysxXOldutVCKZAtqQFvHwJyullcmfUUinXjaKKr-2jKW6okCCkq-uYf9DotOdb1NG2B1z-noqsUPVA2p1Ky84_DENA_KtSHCnWtUP-sUN9V0-s_13i0_OqsAuwAlCrFncu_3_5P7HdbX6jp</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Jakovac, Hrvoje</creator><creator>Stašić, Nikola</creator><creator>Krašević, Maja</creator><creator>Jonjić, Nives</creator><creator>Radošević-Stašić, Biserka</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3331-9320</orcidid><orcidid>https://orcid.org/0000-0003-2995-0766</orcidid><orcidid>https://orcid.org/0000-0001-8174-5124</orcidid></search><sort><creationdate>20210401</creationdate><title>Expression profiles of metallothionein-I/II and megalin/LRP-2 in uterine cervical squamous lesions</title><author>Jakovac, Hrvoje ; Stašić, Nikola ; Krašević, Maja ; Jonjić, Nives ; Radošević-Stašić, Biserka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-f0a3bdfa02dbe8c2905ad5c10d040f2740d770de93ba69cf808b96878685bf923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>AKT1 protein</topic><topic>Apoptosis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cancer</topic><topic>Cancer screening</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cervical cancer</topic><topic>Cervical Intraepithelial Neoplasia - diagnosis</topic><topic>Cervical Intraepithelial Neoplasia - genetics</topic><topic>Cervical Intraepithelial Neoplasia - metabolism</topic><topic>Cervical Intraepithelial Neoplasia - pathology</topic><topic>Cervix</topic><topic>Dysplasia</topic><topic>Early Detection of Cancer</topic><topic>Endocytosis</topic><topic>Endothelium</topic><topic>Epithelium</topic><topic>Female</topic><topic>Free radicals</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Immunoreactivity</topic><topic>Inflammation</topic><topic>Lesions</topic><topic>Localization</topic><topic>Low Density Lipoprotein Receptor-Related Protein-2 - genetics</topic><topic>Low Density Lipoprotein Receptor-Related Protein-2 - metabolism</topic><topic>LRP2 protein</topic><topic>Medical screening</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metallothionein</topic><topic>Metallothionein - genetics</topic><topic>Metallothionein - metabolism</topic><topic>Metallothioneins</topic><topic>Original</topic><topic>Original Article</topic><topic>Pathology</topic><topic>Pattern analysis</topic><topic>Phylogeny</topic><topic>Proteins</topic><topic>Scavenging</topic><topic>Signal transduction</topic><topic>Squamous cells</topic><topic>Stroma</topic><topic>Transcriptome</topic><topic>Tumor Microenvironment</topic><topic>Uterine Cervical Neoplasms - diagnosis</topic><topic>Uterine Cervical Neoplasms - genetics</topic><topic>Uterine Cervical Neoplasms - metabolism</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jakovac, Hrvoje</creatorcontrib><creatorcontrib>Stašić, Nikola</creatorcontrib><creatorcontrib>Krašević, Maja</creatorcontrib><creatorcontrib>Jonjić, Nives</creatorcontrib><creatorcontrib>Radošević-Stašić, Biserka</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Virchows Archiv : an international journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jakovac, Hrvoje</au><au>Stašić, Nikola</au><au>Krašević, Maja</au><au>Jonjić, Nives</au><au>Radošević-Stašić, Biserka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression profiles of metallothionein-I/II and megalin/LRP-2 in uterine cervical squamous lesions</atitle><jtitle>Virchows Archiv : an international journal of pathology</jtitle><stitle>Virchows Arch</stitle><addtitle>Virchows Arch</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>478</volume><issue>4</issue><spage>735</spage><epage>746</epage><pages>735-746</pages><issn>0945-6317</issn><eissn>1432-2307</eissn><abstract>Metallothioneins (MTs) are phylogenetically old cysteine-rich proteins, which are implicated in a variety of physiological and pathological processes. Their growth-regulating, anti-apoptotic and anti-inflammatory functions have been attributed not only to intracellular free radical scavenging and to zinc and copper regulation but also to the ability of secreted MT to bind on surface lipoprotein receptor-megalin/LRP2, which enables the endocytosis of MT-I/II and a wide range of other functionally distinct ligands. In the present study, we analysed the expression pattern of both proteins in 55 cases of premalignant transformation of cervical squamous cells, i.e. in low- and high-grade squamous intraepithelial lesion (LSIL and HSIL). The data showed that in LSIL (cervical intraepithelial neoplasia CIN1;
N
= 25) MTs were present only in basal and parabasal cells and that megalin was only weakly expressed. In HSIL (CIN2;
N
= 15 and CIN 3/carcinoma in situ;
N
= 15), however, overexpression and co-localization of MT with megalin were found in the entire hyperplastic epithelium. Moreover, megalin immunoreactivity appeared on the glandular epithelium and vascular endothelium, as well as on lymphatic cells in stroma. Besides, multiple megalin-positive cells expressed phosphorylated Akt1, implying that MT- and/or megalin-dependent prosurvival signal transduction pathways might contribute to the development of severe cervical dysplasia. The data emphasize the diagnostic power of combined MT/megalin analysis in pre-cancer screening.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33084977</pmid><doi>10.1007/s00428-020-02947-w</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-3331-9320</orcidid><orcidid>https://orcid.org/0000-0003-2995-0766</orcidid><orcidid>https://orcid.org/0000-0001-8174-5124</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | AKT1 protein Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Cancer screening Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cervical cancer Cervical Intraepithelial Neoplasia - diagnosis Cervical Intraepithelial Neoplasia - genetics Cervical Intraepithelial Neoplasia - metabolism Cervical Intraepithelial Neoplasia - pathology Cervix Dysplasia Early Detection of Cancer Endocytosis Endothelium Epithelium Female Free radicals Gene Expression Profiling Gene Expression Regulation, Neoplastic Human papillomavirus Humans Immunohistochemistry Immunoreactivity Inflammation Lesions Localization Low Density Lipoprotein Receptor-Related Protein-2 - genetics Low Density Lipoprotein Receptor-Related Protein-2 - metabolism LRP2 protein Medical screening Medicine Medicine & Public Health Metallothionein Metallothionein - genetics Metallothionein - metabolism Metallothioneins Original Original Article Pathology Pattern analysis Phylogeny Proteins Scavenging Signal transduction Squamous cells Stroma Transcriptome Tumor Microenvironment Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology Uterus |
| title | Expression profiles of metallothionein-I/II and megalin/LRP-2 in uterine cervical squamous lesions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T13%3A14%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20profiles%20of%20metallothionein-I/II%20and%20megalin/LRP-2%20in%20uterine%20cervical%20squamous%20lesions&rft.jtitle=Virchows%20Archiv%20:%20an%20international%20journal%20of%20pathology&rft.au=Jakovac,%20Hrvoje&rft.date=2021-04-01&rft.volume=478&rft.issue=4&rft.spage=735&rft.epage=746&rft.pages=735-746&rft.issn=0945-6317&rft.eissn=1432-2307&rft_id=info:doi/10.1007/s00428-020-02947-w&rft_dat=%3Cproquest_pubme%3E2452980787%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2504631276&rft_id=info:pmid/33084977&rfr_iscdi=true |