Molecular mechanisms of An-Chuan Granule for the treatment of asthma based on a network pharmacology approach and experimental validation

An-Chuan Granule (ACG), a traditional Chinese medicine (TCM) formula, is an effective treatment for asthma but its pharmacological mechanism remains poorly understood. In the present study, network pharmacology was applied to explore the potential mechanism of ACG in the treatment of asthma. The tum...

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Veröffentlicht in:	Bioscience reports 2021-03, Vol.41 (3)
Hauptverfasser:	Chen, Xiao-Li, Xiao, Qing-Ling, Pang, Zhong-Hua, Tang, Cheng, Zhu, Qi-Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenosquamous Animals Asthma Asthma - drug therapy Asthma - immunology Bioavailability Bronchus Caspase-1 Cell differentiation Chinese medicine Differentiation (biology) Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Forkhead protein Forkhead Transcription Factors - metabolism Foxp3 protein Granular materials Helper cells Herbal medicine Inflammation Ingredients Interleukins Interleukins - metabolism Laboratory animals Lavage Lung - drug effects Lung - metabolism Lung carcinoma Lungs Lymphocytes T Male Metastases Mice Mice, Inbred BALB C Molecular modelling Mucin 5AC - metabolism NF-kappa B - metabolism NF-κB protein NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism Nucleotides Oligomerization Ovalbumin Pharmacology Respiratory System Squamous cell carcinoma T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Th17 Cells - drug effects Th17 Cells - immunology Therapeutics & Molecular Medicine TLR4 protein Toll-like receptors Toll-Like Receptors - metabolism Traditional Chinese medicine Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism
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