Pathophysiology of Neurogenic Obesity After Spinal Cord Injury
Individuals with a spinal cord injury (SCI) have a unique physiology characterized by sarcopenia, neurogenic osteoporosis, neurogenic anabolic deficiency, sympathetic dysfunction, and blunted satiety associated with their SCI, all of which alter energy balance and subsequently body composition. The...
Gespeichert in:
| Veröffentlicht in: | Topics in spinal cord injury rehabilitation 2021, Vol.27 (1), p.1-10 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 10 |
|---|---|
| container_issue | 1 |
| container_start_page | 1 |
| container_title | Topics in spinal cord injury rehabilitation |
| container_volume | 27 |
| creator | Gater, Jr, David R Farkas, Gary J Tiozzo, Eduard |
| description | Individuals with a spinal cord injury (SCI) have a unique physiology characterized by sarcopenia, neurogenic osteoporosis, neurogenic anabolic deficiency, sympathetic dysfunction, and blunted satiety associated with their SCI, all of which alter energy balance and subsequently body composition. The distinct properties of "neurogenic obesity" place this population at great risk for metabolic dysfunction, including systemic inflammation, hyperglycemia, dyslipidemia, and hypertension. The purpose of this article is to demonstrate the relationship between neurogenic obesity and the metabolic syndrome after SCI, highlighting the mechanisms associated with adipose tissue pathology and those respective comorbidities. Additionally, representative studies of persons with SCI will be provided to elucidate the severity of the problem and to prompt greater vigilance among SCI specialists as well as primary care providers in order to better manage the epidemic from a public health perspective. |
| doi_str_mv | 10.46292/sci20-00067 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7983633</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2555271890</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-11cadd32e2b40c8a1bc0df0678397d2bfec2e7c35596fc2a66886f03d6ccd6123</originalsourceid><addsrcrecordid>eNpdkc9LwzAUx4Mobk5vnqXgxYPVl6RN08tgDH8MxAnqOaRpumV0TU1aof-9dZtDPb0H78OX7-OD0DmGm4iRlNx6ZQiEAMCSAzTEaRSHccLoYb8DJyEkUTRAJ96vAAjmAMdoQCnHEU_SIRq_yGZp62XnjS3togtsETzr1tmFrowK5pn2pumCSdFoF7zWppJlMLUuD2bVqnXdKToqZOn12W6O0Pv93dv0MXyaP8ymk6dQRZg0IcZK5jklmmQRKC5xpiAv-sKcpklOskIrohNF4zhlhSKSMc5ZATRnSuUMEzpC421u3WZrnStdNU6WonZmLV0nrDTi76UyS7GwnyJJOWWU9gFXuwBnP1rtG7E2XumylJW2rRckBs55Coz36OU_dGVb1z_-TcUxSXDP9dT1llLOeu90sS-DQWzEiI0YsRHT4xe_H9jDPyboFzj7iZ0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2555271890</pqid></control><display><type>article</type><title>Pathophysiology of Neurogenic Obesity After Spinal Cord Injury</title><source>MEDLINE</source><source>PubMed Central</source><source>EZB Electronic Journals Library</source><source>Allen Press Miscellaneous</source><creator>Gater, Jr, David R ; Farkas, Gary J ; Tiozzo, Eduard</creator><creatorcontrib>Gater, Jr, David R ; Farkas, Gary J ; Tiozzo, Eduard</creatorcontrib><description>Individuals with a spinal cord injury (SCI) have a unique physiology characterized by sarcopenia, neurogenic osteoporosis, neurogenic anabolic deficiency, sympathetic dysfunction, and blunted satiety associated with their SCI, all of which alter energy balance and subsequently body composition. The distinct properties of "neurogenic obesity" place this population at great risk for metabolic dysfunction, including systemic inflammation, hyperglycemia, dyslipidemia, and hypertension. The purpose of this article is to demonstrate the relationship between neurogenic obesity and the metabolic syndrome after SCI, highlighting the mechanisms associated with adipose tissue pathology and those respective comorbidities. Additionally, representative studies of persons with SCI will be provided to elucidate the severity of the problem and to prompt greater vigilance among SCI specialists as well as primary care providers in order to better manage the epidemic from a public health perspective.</description><identifier>ISSN: 1082-0744</identifier><identifier>ISSN: 1945-5763</identifier><identifier>EISSN: 1945-5763</identifier><identifier>DOI: 10.46292/sci20-00067</identifier><identifier>PMID: 33814879</identifier><language>eng</language><publisher>United States: Allen Press Inc</publisher><subject>Adipocytes ; Amino acids ; Apoptosis ; Body mass index ; Cholesterol ; Cytokines ; Diabetes ; Energy ; Fatty acids ; Gene expression ; Glucose ; Humans ; Hyperglycemia ; Hypertension ; Inflammation ; Insulin resistance ; Kinases ; Liver ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - etiology ; Metabolites ; Musculoskeletal system ; Nervous system ; Obesity ; Obesity - complications ; Obesity - physiopathology ; Proteins ; Spinal cord injuries ; Spinal Cord Injuries - complications ; Spinal Cord Injuries - physiopathology ; Triglycerides</subject><ispartof>Topics in spinal cord injury rehabilitation, 2021, Vol.27 (1), p.1-10</ispartof><rights>2021 American Spinal Injury Association.</rights><rights>Copyright Allen Press Inc. 2021</rights><rights>2021 American Spinal Injury Association 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-11cadd32e2b40c8a1bc0df0678397d2bfec2e7c35596fc2a66886f03d6ccd6123</citedby><cites>FETCH-LOGICAL-c412t-11cadd32e2b40c8a1bc0df0678397d2bfec2e7c35596fc2a66886f03d6ccd6123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983633/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983633/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33814879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gater, Jr, David R</creatorcontrib><creatorcontrib>Farkas, Gary J</creatorcontrib><creatorcontrib>Tiozzo, Eduard</creatorcontrib><title>Pathophysiology of Neurogenic Obesity After Spinal Cord Injury</title><title>Topics in spinal cord injury rehabilitation</title><addtitle>Top Spinal Cord Inj Rehabil</addtitle><description>Individuals with a spinal cord injury (SCI) have a unique physiology characterized by sarcopenia, neurogenic osteoporosis, neurogenic anabolic deficiency, sympathetic dysfunction, and blunted satiety associated with their SCI, all of which alter energy balance and subsequently body composition. The distinct properties of "neurogenic obesity" place this population at great risk for metabolic dysfunction, including systemic inflammation, hyperglycemia, dyslipidemia, and hypertension. The purpose of this article is to demonstrate the relationship between neurogenic obesity and the metabolic syndrome after SCI, highlighting the mechanisms associated with adipose tissue pathology and those respective comorbidities. Additionally, representative studies of persons with SCI will be provided to elucidate the severity of the problem and to prompt greater vigilance among SCI specialists as well as primary care providers in order to better manage the epidemic from a public health perspective.</description><subject>Adipocytes</subject><subject>Amino acids</subject><subject>Apoptosis</subject><subject>Body mass index</subject><subject>Cholesterol</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Energy</subject><subject>Fatty acids</subject><subject>Gene expression</subject><subject>Glucose</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Hypertension</subject><subject>Inflammation</subject><subject>Insulin resistance</subject><subject>Kinases</subject><subject>Liver</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - etiology</subject><subject>Metabolites</subject><subject>Musculoskeletal system</subject><subject>Nervous system</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - physiopathology</subject><subject>Proteins</subject><subject>Spinal cord injuries</subject><subject>Spinal Cord Injuries - complications</subject><subject>Spinal Cord Injuries - physiopathology</subject><subject>Triglycerides</subject><issn>1082-0744</issn><issn>1945-5763</issn><issn>1945-5763</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkc9LwzAUx4Mobk5vnqXgxYPVl6RN08tgDH8MxAnqOaRpumV0TU1aof-9dZtDPb0H78OX7-OD0DmGm4iRlNx6ZQiEAMCSAzTEaRSHccLoYb8DJyEkUTRAJ96vAAjmAMdoQCnHEU_SIRq_yGZp62XnjS3togtsETzr1tmFrowK5pn2pumCSdFoF7zWppJlMLUuD2bVqnXdKToqZOn12W6O0Pv93dv0MXyaP8ymk6dQRZg0IcZK5jklmmQRKC5xpiAv-sKcpklOskIrohNF4zhlhSKSMc5ZATRnSuUMEzpC421u3WZrnStdNU6WonZmLV0nrDTi76UyS7GwnyJJOWWU9gFXuwBnP1rtG7E2XumylJW2rRckBs55Coz36OU_dGVb1z_-TcUxSXDP9dT1llLOeu90sS-DQWzEiI0YsRHT4xe_H9jDPyboFzj7iZ0</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Gater, Jr, David R</creator><creator>Farkas, Gary J</creator><creator>Tiozzo, Eduard</creator><general>Allen Press Inc</general><general>Thomas Land Publishers, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>KB0</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2021</creationdate><title>Pathophysiology of Neurogenic Obesity After Spinal Cord Injury</title><author>Gater, Jr, David R ; Farkas, Gary J ; Tiozzo, Eduard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-11cadd32e2b40c8a1bc0df0678397d2bfec2e7c35596fc2a66886f03d6ccd6123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adipocytes</topic><topic>Amino acids</topic><topic>Apoptosis</topic><topic>Body mass index</topic><topic>Cholesterol</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Energy</topic><topic>Fatty acids</topic><topic>Gene expression</topic><topic>Glucose</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Hypertension</topic><topic>Inflammation</topic><topic>Insulin resistance</topic><topic>Kinases</topic><topic>Liver</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - etiology</topic><topic>Metabolites</topic><topic>Musculoskeletal system</topic><topic>Nervous system</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - physiopathology</topic><topic>Proteins</topic><topic>Spinal cord injuries</topic><topic>Spinal Cord Injuries - complications</topic><topic>Spinal Cord Injuries - physiopathology</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gater, Jr, David R</creatorcontrib><creatorcontrib>Farkas, Gary J</creatorcontrib><creatorcontrib>Tiozzo, Eduard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Topics in spinal cord injury rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gater, Jr, David R</au><au>Farkas, Gary J</au><au>Tiozzo, Eduard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathophysiology of Neurogenic Obesity After Spinal Cord Injury</atitle><jtitle>Topics in spinal cord injury rehabilitation</jtitle><addtitle>Top Spinal Cord Inj Rehabil</addtitle><date>2021</date><risdate>2021</risdate><volume>27</volume><issue>1</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>1082-0744</issn><issn>1945-5763</issn><eissn>1945-5763</eissn><abstract>Individuals with a spinal cord injury (SCI) have a unique physiology characterized by sarcopenia, neurogenic osteoporosis, neurogenic anabolic deficiency, sympathetic dysfunction, and blunted satiety associated with their SCI, all of which alter energy balance and subsequently body composition. The distinct properties of "neurogenic obesity" place this population at great risk for metabolic dysfunction, including systemic inflammation, hyperglycemia, dyslipidemia, and hypertension. The purpose of this article is to demonstrate the relationship between neurogenic obesity and the metabolic syndrome after SCI, highlighting the mechanisms associated with adipose tissue pathology and those respective comorbidities. Additionally, representative studies of persons with SCI will be provided to elucidate the severity of the problem and to prompt greater vigilance among SCI specialists as well as primary care providers in order to better manage the epidemic from a public health perspective.</abstract><cop>United States</cop><pub>Allen Press Inc</pub><pmid>33814879</pmid><doi>10.46292/sci20-00067</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1082-0744 |
| ispartof | Topics in spinal cord injury rehabilitation, 2021, Vol.27 (1), p.1-10 |
| issn | 1082-0744 1945-5763 1945-5763 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7983633 |
| source | MEDLINE; PubMed Central; EZB Electronic Journals Library; Allen Press Miscellaneous |
| subjects | Adipocytes Amino acids Apoptosis Body mass index Cholesterol Cytokines Diabetes Energy Fatty acids Gene expression Glucose Humans Hyperglycemia Hypertension Inflammation Insulin resistance Kinases Liver Metabolic disorders Metabolic syndrome Metabolic Syndrome - etiology Metabolites Musculoskeletal system Nervous system Obesity Obesity - complications Obesity - physiopathology Proteins Spinal cord injuries Spinal Cord Injuries - complications Spinal Cord Injuries - physiopathology Triglycerides |
| title | Pathophysiology of Neurogenic Obesity After Spinal Cord Injury |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T08%3A10%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pathophysiology%20of%20Neurogenic%20Obesity%20After%20Spinal%20Cord%20Injury&rft.jtitle=Topics%20in%20spinal%20cord%20injury%20rehabilitation&rft.au=Gater,%20Jr,%20David%20R&rft.date=2021&rft.volume=27&rft.issue=1&rft.spage=1&rft.epage=10&rft.pages=1-10&rft.issn=1082-0744&rft.eissn=1945-5763&rft_id=info:doi/10.46292/sci20-00067&rft_dat=%3Cproquest_pubme%3E2555271890%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2555271890&rft_id=info:pmid/33814879&rfr_iscdi=true |