Harmful Effects of Granulocytic Myeloid-Derived Suppressor Cells on Tuberculosis Caused by Hypervirulent Mycobacteria

Abstract Background The role of myeloid-derived suppressor cells (MDSCs) in patients with severe tuberculosis who suffer from uncontrolled pulmonary inflammation caused by hypervirulent mycobacterial infection remains unclear. Methods This issue was addressed using C57BL/6 mice infected with highly...

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Veröffentlicht in:	The Journal of infectious diseases 2021-02, Vol.223 (3), p.494-507
Hauptverfasser:	Barbosa Bomfim, Caio César, Pinheiro Amaral, Eduardo, Santiago-Carvalho, Igor, Almeida Santos, Gislane, Machado Salles, Érika, Hastreiter, Araceli Aparecida, Silva do Nascimento, Rogério, Almeida, Fabrício M, Lopes Biá Ventura Simão, Thatiana, Linhares Rezende, Andreza, Hiroyuki Hirata, Mario, Ambrósio Fock, Ricardo, Álvarez, José Maria, Lasunskaia, Elena B, D’Império Lima, Maria Regina
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacilli Bone marrow CD11b antigen Cell proliferation Inflammation Leukocytes (neutrophilic) Lung diseases Lungs Lymphocytes T Major and Brief Reports Neutrophils Pulmonary lesions Suppressor cells Tuberculosis γ-Interferon
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