Acetylcholine ameliorates colitis by promoting IL-10 secretion of monocytic myeloid-derived suppressor cells through the nAChR/ERK pathway

The alteration of the enteric nervous system (ENS) and its role in neuroimmune modulation remain obscure in the pathogenesis of inflammatory bowel diseases (IBDs). Here, by using the xCell tool and the latest immunolabeling-enabled three-dimensional (3D) imaging of solvent-cleared organs technique,...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-03, Vol.118 (11), p.1-9
Hauptverfasser:	Zheng, Wanwei, Song, Huan, Luo, Zhongguang, Wu, Hao, Chen, Lin, Wang, Yuedi, Cui, Haoshu, Zhang, Yufei, Wang, Bangting, Li, Wenshuai, Liu, Yao, Zhang, Jun, Chu, Yiwei, Luo, Feifei, Liu, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Acetylcholine receptors (nicotinic) Acetyltransferase Biological Sciences Choline Choline O-acetyltransferase Cholinergics Colitis Colon Enteric nervous system Extracellular signal-regulated kinase Inflammation Inflammatory bowel disease Inflammatory bowel diseases Interleukin 10 Intestine Metabolic pathways Monocytes Nervous system Neuromodulation Neurotransmitters Organs Pathogenesis Signal transduction Suppressor cells
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