Neuronal non-CG methylation is an essential target for MeCP2 function

DNA methylation is implicated in neuronal biology via the protein MeCP2, the mutation of which causes Rett syndrome. MeCP2 recruits the NCOR1/2 co-repressor complexes to methylated cytosine in the CG dinucleotide, but also to sites of non-CG methylation, which are abundant in neurons. To test the bi...

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Veröffentlicht in:	Molecular cell 2021-03, Vol.81 (6), p.1260-1275.e12
Hauptverfasser:	Tillotson, Rebekah, Cholewa-Waclaw, Justyna, Chhatbar, Kashyap, Connelly, John C., Kirschner, Sophie A., Webb, Shaun, Koerner, Martha V., Selfridge, Jim, Kelly, David A., De Sousa, Dina, Brown, Kyla, Lyst, Matthew J., Kriaucionis, Skirmantas, Bird, Adrian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CpG Islands DNA Methylation epigenetic reader Gene Knock-In Techniques HeLa Cells Humans Male MeCP2 Methyl-CpG-Binding Protein 2 - genetics Methyl-CpG-Binding Protein 2 - metabolism Mice Mice, Transgenic mouse Mutation neuronal maintenance Neurons - metabolism Neurons - pathology NIH 3T3 Cells Protein Domains Rett syndrome Rett Syndrome - genetics Rett Syndrome - metabolism Rett Syndrome - pathology transcriptional regulation
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