Novel curcumin analog (cis-trans curcumin) as ligand to adenosine receptors A2A and A2B: potential for therapeutics

Interaction of CTCUR (keto form) with amino acid residues of A) AR A2A and B) AR A2B. [Display omitted] All four of the adenosine receptor (AR) subtypes mediate pain and have been targeted by pharmacologists to generate new therapeutics for chronic pain. The vanilloid phytochemicals, which include c...

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Veröffentlicht in:	Pharmacological research 2021-03, Vol.165, p.105410-105410, Article 105410
Hauptverfasser:	Hamilton, Luke J., Walker, Michaela, Pattabiraman, Mahesh, Zhong, Haizhen A., Luedtke, Brandon, Chandra, Surabhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine receptor A2A Adenosine receptor A2B Chronic pain Curcumin Gstimulatory
Online-Zugang:	Volltext
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