GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKα activity

Albuminuria is an early clinical feature in the progression of diabetic nephropathy (DN). Podocyte insulin resistance is a main cause of podocyte injury, playing crucial roles by contributing to albuminuria in early DN. G protein-coupled receptor 43 (GPR43) is a metabolite sensor modulating the cell...

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Veröffentlicht in:	Theranostics 2021-01, Vol.11 (10), p.4728-4742
Hauptverfasser:	Lu, Jian, Chen, Pei Pei, Zhang, Jia Xiu, Li, Xue Qi, Wang, Gui Hua, Yuan, Ben Yin, Huang, Si Jia, Liu, Xiao Qi, Jiang, Ting Ting, Wang, Meng Ying, Liu, Wen Tao, Ruan, Xiong Zhong, Liu, Bi Cheng, Ma, Kun Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Cholesterol Creatinine Diabetes Diabetic nephropathy Enzymes Experiments Gene expression Glucose Glycerol Homeostasis Insulin resistance Kinases Microbiota Proteins Research Paper Ribosomal DNA Rodents
Online-Zugang:	Volltext
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