Tyrosine kinase inhibitors protect the salivary gland from radiation damage by increasing DNA double-strand break repair

We have previously shown that the tyrosine kinase inhibitors (TKIs) dasatinib and imatinib can protect salivary glands from irradiation (IR) damage without impacting tumor therapy. However, how they induce this protection is unknown. Here we show that TKIs mediate radioprotection by increasing the r...

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Veröffentlicht in:	The Journal of biological chemistry 2021-01, Vol.296, p.100401-100401, Article 100401
Hauptverfasser:	Affandi, Trisiani, Ohm, Angela M., Gaillard, Dany, Haas, Ami, Reyland, Mary E.
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA damage DNA repair protein kinase C-δ radioprotection salivary gland tyrosine kinase inhibitor
Online-Zugang:	Volltext
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