Mechanisms of spacer acquisition by sequential assembly of the adaptation module in Synechocystis

Abstract CRISPR–Cas immune systems process and integrate short fragments of DNA from new invaders as spacers into the host CRISPR locus to establish molecular memory of prior infection, which is also known as adaptation in the field. Some CRISPR–Cas systems rely on Cas1 and Cas2 to complete the adap...

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Veröffentlicht in:	Nucleic acids research 2021-03, Vol.49 (5), p.2973-2984
Hauptverfasser:	Wu, Chengyong, Tang, Dongmei, Cheng, Jie, Hu, Daojun, Yang, Zejing, Ma, Xue, He, Haihuai, Yao, Shaohua, Fu, Tian-Min, Yu, Yamei, Chen, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	CRISPR-Associated Proteins - chemistry CRISPR-Cas Systems Crystallography, X-Ray DNA - chemistry Models, Molecular Structural Biology Synechocystis - genetics
Online-Zugang:	Volltext
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