An efficient synthetic route to l-γ-methyleneglutamine and its amide derivatives, and their selective anticancer activity

In cancer cells, glutaminolysis is the primary source of biosynthetic precursors, fueling the TCA cycle with glutamine-derived α-ketoglutarate. The enhanced production of α-ketoglutarate is critical to cancer cells as it provides carbons for the TCA cycle to produce glutathione, fatty acids, and nuc...

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Veröffentlicht in:	RSC advances 2021-02, Vol.11 (13), p.7115-7128
Hauptverfasser:	Hossain, Md Imran, Thomas, Ajit G, Mahdi, Fakhri, Adam, Amna T, Akins, Nicholas S, Woodard, Morgan M, Paris, Jason J, Slusher, Barbara S, Le, Hoang V
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Amino acids Anticancer properties Breast cancer Cell growth Chemistry Derivatives Fatty acids Glutamine Glutathione Nitrogen NMR spectroscopy Nucleotides Tamoxifen Toxicity
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