Brain structure and function in patients after metal-on-metal hip resurfacing
Hip prostheses that use a metal-on-metal articulation expose the brain to elevated metal concentrations that, in acute excess due to prosthesis malfunction, is associated with neurologic damage, including visual and hearing loss and motor deficits. Here, we examined whether chronic exposure to lower...
Gespeichert in:
| Veröffentlicht in: | American journal of neuroradiology : AJNR 2014-09, Vol.35 (9), p.1753-1758 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1758 |
|---|---|
| container_issue | 9 |
| container_start_page | 1753 |
| container_title | American journal of neuroradiology : AJNR |
| container_volume | 35 |
| creator | Clark, M J Prentice, J R Hoggard, N Paley, M N Hadjivassiliou, M Wilkinson, J M |
| description | Hip prostheses that use a metal-on-metal articulation expose the brain to elevated metal concentrations that, in acute excess due to prosthesis malfunction, is associated with neurologic damage, including visual and hearing loss and motor deficits. Here, we examined whether chronic exposure to lower elevated metal levels, typical of well-functioning prostheses, also affects brain structure and function.
We compared brain volumes, metal deposition, and gray matter attenuation by MR imaging and clinical neurologic function in patients 8 years after receiving a metal-on-metal hip resurfacing versus a matched group of patients with the same duration exposure to a conventional hip prosthesis.
Twenty-nine patients (25 men; mean, age 59±7 years) after metal-on-metal hip resurfacing and 29 patients (25 men; 59±8 years) after total hip arthroplasty were compared. Whole blood cobalt and chromium concentrations were 5-10 times higher in the metal-on-metal hip resurfacing group (P |
| doi_str_mv | 10.3174/ajnr.A3922 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7966284</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1808623066</sourcerecordid><originalsourceid>FETCH-LOGICAL-c477t-92b0e9cc9a5c5408d2bf83b3a61f27407a671078d2755dff3b6dfa8c0ffaad4e3</originalsourceid><addsrcrecordid>eNpVkEtLAzEUhYMotj42_gCZpQijecwkk41QxRdU3Ci4C3cySZsyzdQkI_jvnVYturqXew7nHj6ETgi-YEQUl7Dw4WLCJKU7aEwk47ks5dsuGmMiy5wTXI3QQYwLjHEpBd1HI1oIShmhY_R0HcD5LKbQ69QHk4FvMtt7nVzns0FZQXLGp5iBTSZkS5OgzTufb5Zs7lZZMLEPFrTzsyO0Z6GN5vhnHqLXu9uXm4d8-nz_eDOZ5roQIuWS1thIrSWUuixw1dDaVqxmwImlosACuCBYDHdRlo21rOaNhUpjawGawrBDdPWdu-rrpWn0UDBAq1bBLSF8qg6c-q94N1ez7kMJyTmtiiHg7CcgdO-9iUktXdSmbcGbro-KVLjilGHOB-v5t1WHLsZg7PYNwWrNX635qw3_wXz6t9jW-gucfQGx-4PU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1808623066</pqid></control><display><type>article</type><title>Brain structure and function in patients after metal-on-metal hip resurfacing</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Clark, M J ; Prentice, J R ; Hoggard, N ; Paley, M N ; Hadjivassiliou, M ; Wilkinson, J M</creator><creatorcontrib>Clark, M J ; Prentice, J R ; Hoggard, N ; Paley, M N ; Hadjivassiliou, M ; Wilkinson, J M</creatorcontrib><description>Hip prostheses that use a metal-on-metal articulation expose the brain to elevated metal concentrations that, in acute excess due to prosthesis malfunction, is associated with neurologic damage, including visual and hearing loss and motor deficits. Here, we examined whether chronic exposure to lower elevated metal levels, typical of well-functioning prostheses, also affects brain structure and function.
We compared brain volumes, metal deposition, and gray matter attenuation by MR imaging and clinical neurologic function in patients 8 years after receiving a metal-on-metal hip resurfacing versus a matched group of patients with the same duration exposure to a conventional hip prosthesis.
Twenty-nine patients (25 men; mean, age 59±7 years) after metal-on-metal hip resurfacing and 29 patients (25 men; 59±8 years) after total hip arthroplasty were compared. Whole blood cobalt and chromium concentrations were 5-10 times higher in the metal-on-metal hip resurfacing group (P<.0001). Occipital cortex gray matter attenuation tended to be lower (P<.005 uncorrected, P>.05 corrected), and the optic chiasm area tended to be lower (mean difference, -2.7 mm2; P=.076) in the metal-on-metal hip resurfacing group. Subgroup analyses in 34 patients (17 per group), after exclusion of primary ocular pathology, showed the same trend in gray matter attenuation in the occipital cortex and basal ganglia and a smaller optic chiasm in the metal-on-metal hip resurfacing group (mean difference, -3.9 mm2; P=.048). No other structural or functional differences were found between the groups.
Chronic exposure to metal-on-metal hip resurfacing is associated with subtle structural change in the visual pathways and the basal ganglia in asymptomatic patients.</description><identifier>ISSN: 0195-6108</identifier><identifier>EISSN: 1936-959X</identifier><identifier>DOI: 10.3174/ajnr.A3922</identifier><identifier>PMID: 24722312</identifier><language>eng</language><publisher>United States: American Society of Neuroradiology</publisher><subject>Adult ; Aged ; Arthroplasty, Replacement, Hip - adverse effects ; Arthroplasty, Replacement, Hip - instrumentation ; Basal Ganglia - pathology ; Brain - pathology ; Chromium - adverse effects ; Cobalt - adverse effects ; Editor's Choice ; Female ; Functional ; Hip Prosthesis - adverse effects ; Humans ; Male ; Middle Aged ; Visual Pathways - pathology</subject><ispartof>American journal of neuroradiology : AJNR, 2014-09, Vol.35 (9), p.1753-1758</ispartof><rights>2014 by American Journal of Neuroradiology.</rights><rights>2014 by American Journal of Neuroradiology 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-92b0e9cc9a5c5408d2bf83b3a61f27407a671078d2755dff3b6dfa8c0ffaad4e3</citedby><cites>FETCH-LOGICAL-c477t-92b0e9cc9a5c5408d2bf83b3a61f27407a671078d2755dff3b6dfa8c0ffaad4e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966284/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966284/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24722312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Clark, M J</creatorcontrib><creatorcontrib>Prentice, J R</creatorcontrib><creatorcontrib>Hoggard, N</creatorcontrib><creatorcontrib>Paley, M N</creatorcontrib><creatorcontrib>Hadjivassiliou, M</creatorcontrib><creatorcontrib>Wilkinson, J M</creatorcontrib><title>Brain structure and function in patients after metal-on-metal hip resurfacing</title><title>American journal of neuroradiology : AJNR</title><addtitle>AJNR Am J Neuroradiol</addtitle><description>Hip prostheses that use a metal-on-metal articulation expose the brain to elevated metal concentrations that, in acute excess due to prosthesis malfunction, is associated with neurologic damage, including visual and hearing loss and motor deficits. Here, we examined whether chronic exposure to lower elevated metal levels, typical of well-functioning prostheses, also affects brain structure and function.
We compared brain volumes, metal deposition, and gray matter attenuation by MR imaging and clinical neurologic function in patients 8 years after receiving a metal-on-metal hip resurfacing versus a matched group of patients with the same duration exposure to a conventional hip prosthesis.
Twenty-nine patients (25 men; mean, age 59±7 years) after metal-on-metal hip resurfacing and 29 patients (25 men; 59±8 years) after total hip arthroplasty were compared. Whole blood cobalt and chromium concentrations were 5-10 times higher in the metal-on-metal hip resurfacing group (P<.0001). Occipital cortex gray matter attenuation tended to be lower (P<.005 uncorrected, P>.05 corrected), and the optic chiasm area tended to be lower (mean difference, -2.7 mm2; P=.076) in the metal-on-metal hip resurfacing group. Subgroup analyses in 34 patients (17 per group), after exclusion of primary ocular pathology, showed the same trend in gray matter attenuation in the occipital cortex and basal ganglia and a smaller optic chiasm in the metal-on-metal hip resurfacing group (mean difference, -3.9 mm2; P=.048). No other structural or functional differences were found between the groups.
Chronic exposure to metal-on-metal hip resurfacing is associated with subtle structural change in the visual pathways and the basal ganglia in asymptomatic patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Arthroplasty, Replacement, Hip - adverse effects</subject><subject>Arthroplasty, Replacement, Hip - instrumentation</subject><subject>Basal Ganglia - pathology</subject><subject>Brain - pathology</subject><subject>Chromium - adverse effects</subject><subject>Cobalt - adverse effects</subject><subject>Editor's Choice</subject><subject>Female</subject><subject>Functional</subject><subject>Hip Prosthesis - adverse effects</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Visual Pathways - pathology</subject><issn>0195-6108</issn><issn>1936-959X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEtLAzEUhYMotj42_gCZpQijecwkk41QxRdU3Ci4C3cySZsyzdQkI_jvnVYturqXew7nHj6ETgi-YEQUl7Dw4WLCJKU7aEwk47ks5dsuGmMiy5wTXI3QQYwLjHEpBd1HI1oIShmhY_R0HcD5LKbQ69QHk4FvMtt7nVzns0FZQXLGp5iBTSZkS5OgzTufb5Zs7lZZMLEPFrTzsyO0Z6GN5vhnHqLXu9uXm4d8-nz_eDOZ5roQIuWS1thIrSWUuixw1dDaVqxmwImlosACuCBYDHdRlo21rOaNhUpjawGawrBDdPWdu-rrpWn0UDBAq1bBLSF8qg6c-q94N1ez7kMJyTmtiiHg7CcgdO-9iUktXdSmbcGbro-KVLjilGHOB-v5t1WHLsZg7PYNwWrNX635qw3_wXz6t9jW-gucfQGx-4PU</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Clark, M J</creator><creator>Prentice, J R</creator><creator>Hoggard, N</creator><creator>Paley, M N</creator><creator>Hadjivassiliou, M</creator><creator>Wilkinson, J M</creator><general>American Society of Neuroradiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20140901</creationdate><title>Brain structure and function in patients after metal-on-metal hip resurfacing</title><author>Clark, M J ; Prentice, J R ; Hoggard, N ; Paley, M N ; Hadjivassiliou, M ; Wilkinson, J M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-92b0e9cc9a5c5408d2bf83b3a61f27407a671078d2755dff3b6dfa8c0ffaad4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arthroplasty, Replacement, Hip - adverse effects</topic><topic>Arthroplasty, Replacement, Hip - instrumentation</topic><topic>Basal Ganglia - pathology</topic><topic>Brain - pathology</topic><topic>Chromium - adverse effects</topic><topic>Cobalt - adverse effects</topic><topic>Editor's Choice</topic><topic>Female</topic><topic>Functional</topic><topic>Hip Prosthesis - adverse effects</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Visual Pathways - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Clark, M J</creatorcontrib><creatorcontrib>Prentice, J R</creatorcontrib><creatorcontrib>Hoggard, N</creatorcontrib><creatorcontrib>Paley, M N</creatorcontrib><creatorcontrib>Hadjivassiliou, M</creatorcontrib><creatorcontrib>Wilkinson, J M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of neuroradiology : AJNR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clark, M J</au><au>Prentice, J R</au><au>Hoggard, N</au><au>Paley, M N</au><au>Hadjivassiliou, M</au><au>Wilkinson, J M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain structure and function in patients after metal-on-metal hip resurfacing</atitle><jtitle>American journal of neuroradiology : AJNR</jtitle><addtitle>AJNR Am J Neuroradiol</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>35</volume><issue>9</issue><spage>1753</spage><epage>1758</epage><pages>1753-1758</pages><issn>0195-6108</issn><eissn>1936-959X</eissn><abstract>Hip prostheses that use a metal-on-metal articulation expose the brain to elevated metal concentrations that, in acute excess due to prosthesis malfunction, is associated with neurologic damage, including visual and hearing loss and motor deficits. Here, we examined whether chronic exposure to lower elevated metal levels, typical of well-functioning prostheses, also affects brain structure and function.
We compared brain volumes, metal deposition, and gray matter attenuation by MR imaging and clinical neurologic function in patients 8 years after receiving a metal-on-metal hip resurfacing versus a matched group of patients with the same duration exposure to a conventional hip prosthesis.
Twenty-nine patients (25 men; mean, age 59±7 years) after metal-on-metal hip resurfacing and 29 patients (25 men; 59±8 years) after total hip arthroplasty were compared. Whole blood cobalt and chromium concentrations were 5-10 times higher in the metal-on-metal hip resurfacing group (P<.0001). Occipital cortex gray matter attenuation tended to be lower (P<.005 uncorrected, P>.05 corrected), and the optic chiasm area tended to be lower (mean difference, -2.7 mm2; P=.076) in the metal-on-metal hip resurfacing group. Subgroup analyses in 34 patients (17 per group), after exclusion of primary ocular pathology, showed the same trend in gray matter attenuation in the occipital cortex and basal ganglia and a smaller optic chiasm in the metal-on-metal hip resurfacing group (mean difference, -3.9 mm2; P=.048). No other structural or functional differences were found between the groups.
Chronic exposure to metal-on-metal hip resurfacing is associated with subtle structural change in the visual pathways and the basal ganglia in asymptomatic patients.</abstract><cop>United States</cop><pub>American Society of Neuroradiology</pub><pmid>24722312</pmid><doi>10.3174/ajnr.A3922</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0195-6108 |
| ispartof | American journal of neuroradiology : AJNR, 2014-09, Vol.35 (9), p.1753-1758 |
| issn | 0195-6108 1936-959X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7966284 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Aged Arthroplasty, Replacement, Hip - adverse effects Arthroplasty, Replacement, Hip - instrumentation Basal Ganglia - pathology Brain - pathology Chromium - adverse effects Cobalt - adverse effects Editor's Choice Female Functional Hip Prosthesis - adverse effects Humans Male Middle Aged Visual Pathways - pathology |
| title | Brain structure and function in patients after metal-on-metal hip resurfacing |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T00%3A47%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Brain%20structure%20and%20function%20in%20patients%20after%20metal-on-metal%20hip%20resurfacing&rft.jtitle=American%20journal%20of%20neuroradiology%20:%20AJNR&rft.au=Clark,%20M%20J&rft.date=2014-09-01&rft.volume=35&rft.issue=9&rft.spage=1753&rft.epage=1758&rft.pages=1753-1758&rft.issn=0195-6108&rft.eissn=1936-959X&rft_id=info:doi/10.3174/ajnr.A3922&rft_dat=%3Cproquest_pubme%3E1808623066%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1808623066&rft_id=info:pmid/24722312&rfr_iscdi=true |