Arterial spin-labeled perfusion of pediatric brain tumors
Pediatric brain tumors have diverse pathologic features, which poses diagnostic challenges. Although perfusion evaluation of adult tumors is well established, hemodynamic properties are not well characterized in children. Our goal was to apply arterial spin-labeling perfusion for various pathologic...
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| Veröffentlicht in: | American journal of neuroradiology : AJNR 2014-02, Vol.35 (2), p.395-401 |
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| creator | Yeom, K W Mitchell, L A Lober, R M Barnes, P D Vogel, H Fisher, P G Edwards, M S |
| description | Pediatric brain tumors have diverse pathologic features, which poses diagnostic challenges. Although perfusion evaluation of adult tumors is well established, hemodynamic properties are not well characterized in children. Our goal was to apply arterial spin-labeling perfusion for various pathologic types of pediatric brain tumors and evaluate the role of arterial spin-labeling in the prediction of tumor grade.
Arterial spin-labeling perfusion of 54 children (mean age, 7.5 years; 33 boys and 21 girls) with treatment-naive brain tumors was retrospectively evaluated. The 3D pseudocontinuous spin-echo arterial spin-labeling technique was acquired at 3T MR imaging. Maximal relative tumor blood flow was obtained by use of the ROI method and was compared with tumor histologic features and grade.
Tumors consisted of astrocytic (20), embryonal (11), ependymal (3), mixed neuronal-glial (8), choroid plexus (5), craniopharyngioma (4), and other pathologic types (3). The maximal relative tumor blood flow of high-grade tumors (grades III and IV) was significantly higher than that of low-grade tumors (grades I and II) (P < .001). There was a wider relative tumor blood flow range among high-grade tumors (2.14 ± 1.78) compared with low-grade tumors (0.60 ± 0.29) (P < .001). Across the cohort, relative tumor blood flow did not distinguish individual histology; however, among posterior fossa tumors, relative tumor blood flow was significantly higher for medulloblastoma compared with pilocytic astrocytoma (P = .014).
Characteristic arterial spin-labeling perfusion patterns were seen among diverse pathologic types of brain tumors in children. Arterial spin-labeling perfusion can be used to distinguish high-grade and low-grade tumors. |
| doi_str_mv | 10.3174/ajnr.A3670 |
| format | Article |
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Arterial spin-labeling perfusion of 54 children (mean age, 7.5 years; 33 boys and 21 girls) with treatment-naive brain tumors was retrospectively evaluated. The 3D pseudocontinuous spin-echo arterial spin-labeling technique was acquired at 3T MR imaging. Maximal relative tumor blood flow was obtained by use of the ROI method and was compared with tumor histologic features and grade.
Tumors consisted of astrocytic (20), embryonal (11), ependymal (3), mixed neuronal-glial (8), choroid plexus (5), craniopharyngioma (4), and other pathologic types (3). The maximal relative tumor blood flow of high-grade tumors (grades III and IV) was significantly higher than that of low-grade tumors (grades I and II) (P < .001). There was a wider relative tumor blood flow range among high-grade tumors (2.14 ± 1.78) compared with low-grade tumors (0.60 ± 0.29) (P < .001). Across the cohort, relative tumor blood flow did not distinguish individual histology; however, among posterior fossa tumors, relative tumor blood flow was significantly higher for medulloblastoma compared with pilocytic astrocytoma (P = .014).
Characteristic arterial spin-labeling perfusion patterns were seen among diverse pathologic types of brain tumors in children. Arterial spin-labeling perfusion can be used to distinguish high-grade and low-grade tumors.</description><identifier>ISSN: 0195-6108</identifier><identifier>EISSN: 1936-959X</identifier><identifier>DOI: 10.3174/ajnr.A3670</identifier><identifier>PMID: 23907239</identifier><language>eng</language><publisher>United States: American Society of Neuroradiology</publisher><subject>Adolescent ; Algorithms ; Brain Neoplasms - pathology ; Child ; Child, Preschool ; Fellows' Journal Club ; Female ; Humans ; Image Enhancement - methods ; Image Interpretation, Computer-Assisted - methods ; Infant ; Magnetic Resonance Angiography - methods ; Male ; Pediatrics ; Reproducibility of Results ; Sensitivity and Specificity ; Spin Labels</subject><ispartof>American journal of neuroradiology : AJNR, 2014-02, Vol.35 (2), p.395-401</ispartof><rights>2014 by American Journal of Neuroradiology 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-fd953514db548a85ed281cbfe1eae05620c3575b87ae60a1dac56e339324edfa3</citedby><cites>FETCH-LOGICAL-c444t-fd953514db548a85ed281cbfe1eae05620c3575b87ae60a1dac56e339324edfa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7965744/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7965744/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23907239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yeom, K W</creatorcontrib><creatorcontrib>Mitchell, L A</creatorcontrib><creatorcontrib>Lober, R M</creatorcontrib><creatorcontrib>Barnes, P D</creatorcontrib><creatorcontrib>Vogel, H</creatorcontrib><creatorcontrib>Fisher, P G</creatorcontrib><creatorcontrib>Edwards, M S</creatorcontrib><title>Arterial spin-labeled perfusion of pediatric brain tumors</title><title>American journal of neuroradiology : AJNR</title><addtitle>AJNR Am J Neuroradiol</addtitle><description>Pediatric brain tumors have diverse pathologic features, which poses diagnostic challenges. Although perfusion evaluation of adult tumors is well established, hemodynamic properties are not well characterized in children. Our goal was to apply arterial spin-labeling perfusion for various pathologic types of pediatric brain tumors and evaluate the role of arterial spin-labeling in the prediction of tumor grade.
Arterial spin-labeling perfusion of 54 children (mean age, 7.5 years; 33 boys and 21 girls) with treatment-naive brain tumors was retrospectively evaluated. The 3D pseudocontinuous spin-echo arterial spin-labeling technique was acquired at 3T MR imaging. Maximal relative tumor blood flow was obtained by use of the ROI method and was compared with tumor histologic features and grade.
Tumors consisted of astrocytic (20), embryonal (11), ependymal (3), mixed neuronal-glial (8), choroid plexus (5), craniopharyngioma (4), and other pathologic types (3). The maximal relative tumor blood flow of high-grade tumors (grades III and IV) was significantly higher than that of low-grade tumors (grades I and II) (P < .001). There was a wider relative tumor blood flow range among high-grade tumors (2.14 ± 1.78) compared with low-grade tumors (0.60 ± 0.29) (P < .001). Across the cohort, relative tumor blood flow did not distinguish individual histology; however, among posterior fossa tumors, relative tumor blood flow was significantly higher for medulloblastoma compared with pilocytic astrocytoma (P = .014).
Characteristic arterial spin-labeling perfusion patterns were seen among diverse pathologic types of brain tumors in children. Arterial spin-labeling perfusion can be used to distinguish high-grade and low-grade tumors.</description><subject>Adolescent</subject><subject>Algorithms</subject><subject>Brain Neoplasms - pathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Fellows' Journal Club</subject><subject>Female</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Infant</subject><subject>Magnetic Resonance Angiography - methods</subject><subject>Male</subject><subject>Pediatrics</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Spin Labels</subject><issn>0195-6108</issn><issn>1936-959X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1LxDAQhoMo7rp68QdIjyJ0TZqkaS7CsvgFC14UvIU0mWqWtqlJK_jv7brropcZhnl4Z3gQOid4Tolg13rdhvmC5gIfoCmRNE8ll6-HaIqJ5GlOcDFBJzGuMcZciuwYTTIqsRjLFMlF6CE4XSexc21a6xJqsEkHoRqi823iq3GwTvfBmaQM2rVJPzQ-xFN0VOk6wtmuz9DL3e3z8iFdPd0_Lher1DDG-rSyklNOmC05K3TBwWYFMWUFBDRgnmfYUC54WQgNOdbEasNzoFTSjIGtNJ2hm21uN5QNWANtH3StuuAaHb6U107937TuXb35TyVkzgVjY8DlLiD4jwFirxoXDdS1bsEPUREmJaFFJooRvdqiJvgYA1T7MwSrjWu1ca1-XI_wxd_H9uivXPoNKDV8Rw</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Yeom, K W</creator><creator>Mitchell, L A</creator><creator>Lober, R M</creator><creator>Barnes, P D</creator><creator>Vogel, H</creator><creator>Fisher, P G</creator><creator>Edwards, M S</creator><general>American Society of Neuroradiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140201</creationdate><title>Arterial spin-labeled perfusion of pediatric brain tumors</title><author>Yeom, K W ; Mitchell, L A ; Lober, R M ; Barnes, P D ; Vogel, H ; Fisher, P G ; Edwards, M S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-fd953514db548a85ed281cbfe1eae05620c3575b87ae60a1dac56e339324edfa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Algorithms</topic><topic>Brain Neoplasms - pathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Fellows' Journal Club</topic><topic>Female</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Infant</topic><topic>Magnetic Resonance Angiography - methods</topic><topic>Male</topic><topic>Pediatrics</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Spin Labels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yeom, K W</creatorcontrib><creatorcontrib>Mitchell, L A</creatorcontrib><creatorcontrib>Lober, R M</creatorcontrib><creatorcontrib>Barnes, P D</creatorcontrib><creatorcontrib>Vogel, H</creatorcontrib><creatorcontrib>Fisher, P G</creatorcontrib><creatorcontrib>Edwards, M S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of neuroradiology : AJNR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yeom, K W</au><au>Mitchell, L A</au><au>Lober, R M</au><au>Barnes, P D</au><au>Vogel, H</au><au>Fisher, P G</au><au>Edwards, M S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arterial spin-labeled perfusion of pediatric brain tumors</atitle><jtitle>American journal of neuroradiology : AJNR</jtitle><addtitle>AJNR Am J Neuroradiol</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>35</volume><issue>2</issue><spage>395</spage><epage>401</epage><pages>395-401</pages><issn>0195-6108</issn><eissn>1936-959X</eissn><abstract>Pediatric brain tumors have diverse pathologic features, which poses diagnostic challenges. Although perfusion evaluation of adult tumors is well established, hemodynamic properties are not well characterized in children. Our goal was to apply arterial spin-labeling perfusion for various pathologic types of pediatric brain tumors and evaluate the role of arterial spin-labeling in the prediction of tumor grade.
Arterial spin-labeling perfusion of 54 children (mean age, 7.5 years; 33 boys and 21 girls) with treatment-naive brain tumors was retrospectively evaluated. The 3D pseudocontinuous spin-echo arterial spin-labeling technique was acquired at 3T MR imaging. Maximal relative tumor blood flow was obtained by use of the ROI method and was compared with tumor histologic features and grade.
Tumors consisted of astrocytic (20), embryonal (11), ependymal (3), mixed neuronal-glial (8), choroid plexus (5), craniopharyngioma (4), and other pathologic types (3). The maximal relative tumor blood flow of high-grade tumors (grades III and IV) was significantly higher than that of low-grade tumors (grades I and II) (P < .001). There was a wider relative tumor blood flow range among high-grade tumors (2.14 ± 1.78) compared with low-grade tumors (0.60 ± 0.29) (P < .001). Across the cohort, relative tumor blood flow did not distinguish individual histology; however, among posterior fossa tumors, relative tumor blood flow was significantly higher for medulloblastoma compared with pilocytic astrocytoma (P = .014).
Characteristic arterial spin-labeling perfusion patterns were seen among diverse pathologic types of brain tumors in children. Arterial spin-labeling perfusion can be used to distinguish high-grade and low-grade tumors.</abstract><cop>United States</cop><pub>American Society of Neuroradiology</pub><pmid>23907239</pmid><doi>10.3174/ajnr.A3670</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Algorithms Brain Neoplasms - pathology Child Child, Preschool Fellows' Journal Club Female Humans Image Enhancement - methods Image Interpretation, Computer-Assisted - methods Infant Magnetic Resonance Angiography - methods Male Pediatrics Reproducibility of Results Sensitivity and Specificity Spin Labels |
| title | Arterial spin-labeled perfusion of pediatric brain tumors |
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