MR Imaging of IgG4-Related Disease in the Head and Neck and Brain
IgG4-related disease is characterized by histologic fibrosis with IgG4-positive plasma cell infiltration. Our study evaluated MR imaging features of IgG4-related disease in the head and neck and brain. Images from 15 patients were retrospectively evaluated for the location, signal intensity, and enh...
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| Veröffentlicht in: | American journal of neuroradiology : AJNR 2012-12, Vol.33 (11), p.2136-2139 |
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| container_title | American journal of neuroradiology : AJNR |
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| creator | TOYODA, K OBA, H KUTOMI, K FURUI, S OOHARA, A MORI, H SAKURAI, K TSUCHIYA, K KAN, S NUMAGUCHI, Y |
| description | IgG4-related disease is characterized by histologic fibrosis with IgG4-positive plasma cell infiltration. Our study evaluated MR imaging features of IgG4-related disease in the head and neck and brain. Images from 15 patients were retrospectively evaluated for the location, signal intensity, and enhancement patterns of lesions. Lacrimal gland enlargement was observed in 8 cases. Other lesions included orbital pseudotumor in 5, pituitary enlargement in 5, and cranial nerve enlargement in 7; the infraorbital nerve was involved in 4. All lesions were hypointense on T2-weighted images, which is typical for IgG4-related lesions. Multiple sites were involved in the head and neck and brain in 11 patients. The diagnosis of IgG4-related disease should be considered in a patient presenting with T2 hypointense lacrimal gland, pituitary, or cranial nerve enlargement, or a T2 hypointense orbital mass, especially if multiple sites in the head and neck are involved in the presence of elevated serum IgG4. |
| doi_str_mv | 10.3174/ajnr.a3147 |
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Our study evaluated MR imaging features of IgG4-related disease in the head and neck and brain. Images from 15 patients were retrospectively evaluated for the location, signal intensity, and enhancement patterns of lesions. Lacrimal gland enlargement was observed in 8 cases. Other lesions included orbital pseudotumor in 5, pituitary enlargement in 5, and cranial nerve enlargement in 7; the infraorbital nerve was involved in 4. All lesions were hypointense on T2-weighted images, which is typical for IgG4-related lesions. Multiple sites were involved in the head and neck and brain in 11 patients. The diagnosis of IgG4-related disease should be considered in a patient presenting with T2 hypointense lacrimal gland, pituitary, or cranial nerve enlargement, or a T2 hypointense orbital mass, especially if multiple sites in the head and neck are involved in the presence of elevated serum IgG4.</description><identifier>ISSN: 0195-6108</identifier><identifier>EISSN: 1936-959X</identifier><identifier>DOI: 10.3174/ajnr.a3147</identifier><identifier>PMID: 22700747</identifier><identifier>CODEN: AAJNDL</identifier><language>eng</language><publisher>Oak Brook, IL: American Society of Neuroradiology</publisher><subject>Adult ; Autoimmune Diseases - immunology ; Autoimmune Diseases - pathology ; Biological and medical sciences ; Brain - pathology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Fellows' Journal Club ; Female ; Head & Neck ; Head - pathology ; Humans ; Immunoglobulin G - immunology ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Middle Aged ; Neck - pathology ; Nervous system ; Neurology ; Radiodiagnosis. Nmr imagery. 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Our study evaluated MR imaging features of IgG4-related disease in the head and neck and brain. Images from 15 patients were retrospectively evaluated for the location, signal intensity, and enhancement patterns of lesions. Lacrimal gland enlargement was observed in 8 cases. Other lesions included orbital pseudotumor in 5, pituitary enlargement in 5, and cranial nerve enlargement in 7; the infraorbital nerve was involved in 4. All lesions were hypointense on T2-weighted images, which is typical for IgG4-related lesions. Multiple sites were involved in the head and neck and brain in 11 patients. The diagnosis of IgG4-related disease should be considered in a patient presenting with T2 hypointense lacrimal gland, pituitary, or cranial nerve enlargement, or a T2 hypointense orbital mass, especially if multiple sites in the head and neck are involved in the presence of elevated serum IgG4.</description><subject>Adult</subject><subject>Autoimmune Diseases - immunology</subject><subject>Autoimmune Diseases - pathology</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Fellows' Journal Club</subject><subject>Female</subject><subject>Head & Neck</subject><subject>Head - pathology</subject><subject>Humans</subject><subject>Immunoglobulin G - immunology</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neck - pathology</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><issn>0195-6108</issn><issn>1936-959X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1PGzEQhi1UBOHj0h9Q-VIJIS3Y6117fakUoCWR-JAikLhZE3s2cbrxgr1B6r_vBgKUU08zo3n0auZ9CfnK2YngqjiFRYgnIHihtsiAayEzXeqHL2TAuC4zyVm1S_ZSWjDGSq3yHbKb54oxVagBGV5P6HgJMx9mtK3peHZZZBNsoENHL3xCSEh9oN0c6QjBUQiO3qD9_dKcRfDhgGzX0CQ83NR9cv_r5935KLu6vRyfD68yWzLVZbJmjgkOFiSX1lpgIq_qYlrpykmNzhV2ahFY7crCcsHzCgAt7-dpbSt0Yp_8eNV9XE2X6CyGLkJjHqNfQvxjWvDm8yb4uZm1z0ZpWUomeoGjjUBsn1aYOrP0yWLTQMB2lQwvSy5F1bv0fzQXuveyd7NHj19RG9uUItbvF3Fm1vGYdTxmuI6nh7_9-8M7-pZHD3zfAJAsNHWEYH364KTKlcq5-AtPrJgC</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>TOYODA, K</creator><creator>OBA, H</creator><creator>KUTOMI, K</creator><creator>FURUI, S</creator><creator>OOHARA, A</creator><creator>MORI, H</creator><creator>SAKURAI, K</creator><creator>TSUCHIYA, K</creator><creator>KAN, S</creator><creator>NUMAGUCHI, Y</creator><general>American Society of Neuroradiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20121201</creationdate><title>MR Imaging of IgG4-Related Disease in the Head and Neck and Brain</title><author>TOYODA, K ; OBA, H ; KUTOMI, K ; FURUI, S ; OOHARA, A ; MORI, H ; SAKURAI, K ; TSUCHIYA, K ; KAN, S ; NUMAGUCHI, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-6f0d031aca616ccca0328f4b898d69edd4cbcea0fd54c13128aaec10fdbfc8ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Autoimmune Diseases - immunology</topic><topic>Autoimmune Diseases - pathology</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Fellows' Journal Club</topic><topic>Female</topic><topic>Head & Neck</topic><topic>Head - pathology</topic><topic>Humans</topic><topic>Immunoglobulin G - immunology</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neck - pathology</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TOYODA, K</creatorcontrib><creatorcontrib>OBA, H</creatorcontrib><creatorcontrib>KUTOMI, K</creatorcontrib><creatorcontrib>FURUI, S</creatorcontrib><creatorcontrib>OOHARA, A</creatorcontrib><creatorcontrib>MORI, H</creatorcontrib><creatorcontrib>SAKURAI, K</creatorcontrib><creatorcontrib>TSUCHIYA, K</creatorcontrib><creatorcontrib>KAN, S</creatorcontrib><creatorcontrib>NUMAGUCHI, Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of neuroradiology : AJNR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TOYODA, K</au><au>OBA, H</au><au>KUTOMI, K</au><au>FURUI, S</au><au>OOHARA, A</au><au>MORI, H</au><au>SAKURAI, K</au><au>TSUCHIYA, K</au><au>KAN, S</au><au>NUMAGUCHI, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MR Imaging of IgG4-Related Disease in the Head and Neck and Brain</atitle><jtitle>American journal of neuroradiology : AJNR</jtitle><addtitle>AJNR Am J Neuroradiol</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>33</volume><issue>11</issue><spage>2136</spage><epage>2139</epage><pages>2136-2139</pages><issn>0195-6108</issn><eissn>1936-959X</eissn><coden>AAJNDL</coden><abstract>IgG4-related disease is characterized by histologic fibrosis with IgG4-positive plasma cell infiltration. Our study evaluated MR imaging features of IgG4-related disease in the head and neck and brain. Images from 15 patients were retrospectively evaluated for the location, signal intensity, and enhancement patterns of lesions. Lacrimal gland enlargement was observed in 8 cases. Other lesions included orbital pseudotumor in 5, pituitary enlargement in 5, and cranial nerve enlargement in 7; the infraorbital nerve was involved in 4. All lesions were hypointense on T2-weighted images, which is typical for IgG4-related lesions. Multiple sites were involved in the head and neck and brain in 11 patients. The diagnosis of IgG4-related disease should be considered in a patient presenting with T2 hypointense lacrimal gland, pituitary, or cranial nerve enlargement, or a T2 hypointense orbital mass, especially if multiple sites in the head and neck are involved in the presence of elevated serum IgG4.</abstract><cop>Oak Brook, IL</cop><pub>American Society of Neuroradiology</pub><pmid>22700747</pmid><doi>10.3174/ajnr.a3147</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Autoimmune Diseases - immunology Autoimmune Diseases - pathology Biological and medical sciences Brain - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Fellows' Journal Club Female Head & Neck Head - pathology Humans Immunoglobulin G - immunology Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Neck - pathology Nervous system Neurology Radiodiagnosis. Nmr imagery. Nmr spectrometry Reproducibility of Results Sensitivity and Specificity |
| title | MR Imaging of IgG4-Related Disease in the Head and Neck and Brain |
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