Regional cerebral blood flow in children from 3 to 5 months of age
Understanding the relationship between brain and behavior in early childhood requires a probe of functional brain development. We report the first large study of regional CBF by use of arterial spin-labeling in young children. Cerebral blood flow by use of arterial spin-labeling was measured in 61 h...
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| Veröffentlicht in: | American journal of neuroradiology : AJNR 2014-03, Vol.35 (3), p.593-598 |
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| container_title | American journal of neuroradiology : AJNR |
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| creator | Duncan, A F Caprihan, A Montague, E Q Lowe, J Schrader, R Phillips, J P |
| description | Understanding the relationship between brain and behavior in early childhood requires a probe of functional brain development. We report the first large study of regional CBF by use of arterial spin-labeling in young children.
Cerebral blood flow by use of arterial spin-labeling was measured in 61 healthy children between the ages of 3 and 5 months. Blood flow maps were parcellated into 8 broadly defined anatomic regions of each cerebral hemisphere.
There was no sex effect; however, group analysis demonstrated significantly greater CBF in the sensorimotor and occipital regions compared with dorsolateral prefrontal, subgenual, and orbitofrontal areas (P < .0001). A significant age effect was also identified, with the largest increase in blood flow between 3 and 5 months occurring in the following regions: orbitofrontal (P < .009), subgenual (P < .002), and inferior occipital lobe (P = .001).
These results are consistent with prior histologic studies demonstrating regional variation in brain maturation and suggest that arterial spin-labeling is sensitive to regional as well as age-related differences in CBF in young children. |
| doi_str_mv | 10.3174/ajnr.A3728 |
| format | Article |
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Cerebral blood flow by use of arterial spin-labeling was measured in 61 healthy children between the ages of 3 and 5 months. Blood flow maps were parcellated into 8 broadly defined anatomic regions of each cerebral hemisphere.
There was no sex effect; however, group analysis demonstrated significantly greater CBF in the sensorimotor and occipital regions compared with dorsolateral prefrontal, subgenual, and orbitofrontal areas (P < .0001). A significant age effect was also identified, with the largest increase in blood flow between 3 and 5 months occurring in the following regions: orbitofrontal (P < .009), subgenual (P < .002), and inferior occipital lobe (P = .001).
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Cerebral blood flow by use of arterial spin-labeling was measured in 61 healthy children between the ages of 3 and 5 months. Blood flow maps were parcellated into 8 broadly defined anatomic regions of each cerebral hemisphere.
There was no sex effect; however, group analysis demonstrated significantly greater CBF in the sensorimotor and occipital regions compared with dorsolateral prefrontal, subgenual, and orbitofrontal areas (P < .0001). A significant age effect was also identified, with the largest increase in blood flow between 3 and 5 months occurring in the following regions: orbitofrontal (P < .009), subgenual (P < .002), and inferior occipital lobe (P = .001).
These results are consistent with prior histologic studies demonstrating regional variation in brain maturation and suggest that arterial spin-labeling is sensitive to regional as well as age-related differences in CBF in young children.</description><subject>Age Factors</subject><subject>Brain Mapping</subject><subject>Cerebrovascular Circulation</subject><subject>Cerebrum - blood supply</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Pediatrics</subject><subject>Spin Labels</subject><issn>0195-6108</issn><issn>1936-959X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkF1LwzAUhoMobk5v_AGSSxE689k0N8IcfoEgiIJ3IU1Pt462mUmn-O_t3Bx6dQ6ch_e8PAidUjLmVIlLu2jDeMIVy_bQkGqeJlrqt300JFTLJKUkG6CjGBeEEKkVO0QDJoimQoghun6GWeVbW2MHAfLQL3ntfYHL2n_iqsVuXtVFgBaXwTeY485jiRvfdvOIfYntDI7RQWnrCCfbOUKvtzcv0_vk8enuYTp5TBxXWZcolTKaOhBOcFIWfRcoOFiqM0bAOpkWWZHnzmpgXNqUKa1ExvKSSlBFyRgfoatN7nKVN1A4aLu-rlmGqrHhy3hbmf-Xtpqbmf8wSqdCEdUHnG8Dgn9fQexMU0UHdW1b8KtoqCRKaS5V2qMXG9QFH2OAcveGErOWbtbSzY_0Hj77W2yH_lrm3wDefaU</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Duncan, A F</creator><creator>Caprihan, A</creator><creator>Montague, E Q</creator><creator>Lowe, J</creator><creator>Schrader, R</creator><creator>Phillips, J P</creator><general>American Society of Neuroradiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140301</creationdate><title>Regional cerebral blood flow in children from 3 to 5 months of age</title><author>Duncan, A F ; Caprihan, A ; Montague, E Q ; Lowe, J ; Schrader, R ; Phillips, J P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-776216ce4c430fd005ed3ea19820eac56d8dbbca9e235a62797482bf15e7df223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Age Factors</topic><topic>Brain Mapping</topic><topic>Cerebrovascular Circulation</topic><topic>Cerebrum - blood supply</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Pediatrics</topic><topic>Spin Labels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duncan, A F</creatorcontrib><creatorcontrib>Caprihan, A</creatorcontrib><creatorcontrib>Montague, E Q</creatorcontrib><creatorcontrib>Lowe, J</creatorcontrib><creatorcontrib>Schrader, R</creatorcontrib><creatorcontrib>Phillips, J P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of neuroradiology : AJNR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duncan, A F</au><au>Caprihan, A</au><au>Montague, E Q</au><au>Lowe, J</au><au>Schrader, R</au><au>Phillips, J P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional cerebral blood flow in children from 3 to 5 months of age</atitle><jtitle>American journal of neuroradiology : AJNR</jtitle><addtitle>AJNR Am J Neuroradiol</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>35</volume><issue>3</issue><spage>593</spage><epage>598</epage><pages>593-598</pages><issn>0195-6108</issn><eissn>1936-959X</eissn><abstract>Understanding the relationship between brain and behavior in early childhood requires a probe of functional brain development. We report the first large study of regional CBF by use of arterial spin-labeling in young children.
Cerebral blood flow by use of arterial spin-labeling was measured in 61 healthy children between the ages of 3 and 5 months. Blood flow maps were parcellated into 8 broadly defined anatomic regions of each cerebral hemisphere.
There was no sex effect; however, group analysis demonstrated significantly greater CBF in the sensorimotor and occipital regions compared with dorsolateral prefrontal, subgenual, and orbitofrontal areas (P < .0001). A significant age effect was also identified, with the largest increase in blood flow between 3 and 5 months occurring in the following regions: orbitofrontal (P < .009), subgenual (P < .002), and inferior occipital lobe (P = .001).
These results are consistent with prior histologic studies demonstrating regional variation in brain maturation and suggest that arterial spin-labeling is sensitive to regional as well as age-related differences in CBF in young children.</abstract><cop>United States</cop><pub>American Society of Neuroradiology</pub><pmid>24091444</pmid><doi>10.3174/ajnr.A3728</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Age Factors Brain Mapping Cerebrovascular Circulation Cerebrum - blood supply Cross-Sectional Studies Female Humans Infant Male Pediatrics Spin Labels |
| title | Regional cerebral blood flow in children from 3 to 5 months of age |
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