Tetrandrine Ameliorates Myocardial Ischemia Reperfusion Injury through miR-202-5p/TRPV2

Objective. This study is aimed at investigating the therapeutic effects of tetrandrine (Tet) on myocardial ischemia reperfusion (I/R) injury and probe into underlying molecular mechanism. Methods. H9C2 cells were divided into hypoxia/oxygenation (H/R) group, H/R+Tet group, H/R+Tet+negative control (...

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Veröffentlicht in:	BioMed research international 2021, Vol.2021 (1), p.8870674-8870674
Hauptverfasser:	Zhao, Wei, Wu, Youyang, Ye, Fanhao, Huang, Shiwei, Chen, Hao, Zhou, Rui, Jiang, Wenbing
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Analysis Animals Apoptosis Benzylisoquinolines - pharmacology Cardiomyocytes Cardiovascular agents Care and treatment Cell culture Cell Line Coronary vessels Enzyme-linked immunosorbent assay Flow cytometry Gene expression Gene Expression Regulation - drug effects Genetic aspects Health aspects Heart attacks Hypoxia Identification and classification Immunohistochemistry Inhibitors Injury prevention Ion channels Ischemia Laboratory animals Male Materia medica, Vegetable Methods MicroRNA MicroRNAs MicroRNAs - biosynthesis Myocardial infarction Myocardial ischemia Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Oxygenation Pharmacology, Experimental Plant extracts Polymerase chain reaction Properties Proteins Rats Rats, Sprague-Dawley Reagents Reperfusion Reperfusion injury Staining Tetrandrine TRPV Cation Channels - biosynthesis Veins & arteries
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