Same pollution sources for climate change might be hyperactivating the NLRP3 inflammasome and exacerbating neuroinflammation and SARS mortality
We have reviewed a considerable amount of recent scientific papers relating inflammation caused by air pollution with chronic and severe medical conditions. Furthermore, there are evidences relating organ inflammation caused by not only outdoor long-term but also short-term inhaled radioisotopes con...
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| Veröffentlicht in: | Medical hypotheses 2021-01, Vol.146, p.110396-110396, Article 110396 |
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| container_title | Medical hypotheses |
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| creator | Macias-Verde, David Lara, Pedro C. Burgos-Burgos, Javier |
| description | We have reviewed a considerable amount of recent scientific papers relating inflammation caused by air pollution with chronic and severe medical conditions. Furthermore, there are evidences relating organ inflammation caused by not only outdoor long-term but also short-term inhaled radioisotopes contained in high polluted air or in household natural radioactive background aerosols, in addition to SARS-COV-2 attached to bioaerosols, which are related with a worst evolution of severe acute respiratory syndrome patients. Reactive oxygen species (ROS) production induced by the interaction with environmental ionizing radiation contained in pollution is pointed out as a critical mechanism that predispose mainly to elder population, but not excluding young subjects, presenting previous chronic conditions of lung inflammation or neuroinflammation, which can lead to the most serious consequences. |
| doi_str_mv | 10.1016/j.mehy.2020.110396 |
| format | Article |
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All rights reserved. 2020 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-c0fd17cc0eb80f4d67b7ee9ff9be44005759541d89b0a746dfd3d1fa922b6ca33</citedby><cites>FETCH-LOGICAL-c455t-c0fd17cc0eb80f4d67b7ee9ff9be44005759541d89b0a746dfd3d1fa922b6ca33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0306987720332874$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33243665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Macias-Verde, David</creatorcontrib><creatorcontrib>Lara, Pedro C.</creatorcontrib><creatorcontrib>Burgos-Burgos, Javier</creatorcontrib><title>Same pollution sources for climate change might be hyperactivating the NLRP3 inflammasome and exacerbating neuroinflammation and SARS mortality</title><title>Medical hypotheses</title><addtitle>Med Hypotheses</addtitle><description>We have reviewed a considerable amount of recent scientific papers relating inflammation caused by air pollution with chronic and severe medical conditions. Furthermore, there are evidences relating organ inflammation caused by not only outdoor long-term but also short-term inhaled radioisotopes contained in high polluted air or in household natural radioactive background aerosols, in addition to SARS-COV-2 attached to bioaerosols, which are related with a worst evolution of severe acute respiratory syndrome patients. Reactive oxygen species (ROS) production induced by the interaction with environmental ionizing radiation contained in pollution is pointed out as a critical mechanism that predispose mainly to elder population, but not excluding young subjects, presenting previous chronic conditions of lung inflammation or neuroinflammation, which can lead to the most serious consequences.</description><subject>Aerosols</subject><subject>Air Microbiology</subject><subject>Air Pollution, Radioactive - adverse effects</subject><subject>Alzheimer’s disease</subject><subject>ARDS</subject><subject>Causality</subject><subject>Climate Change</subject><subject>COVID-19</subject><subject>COVID-19 - etiology</subject><subject>COVID-19 - mortality</subject><subject>Humans</subject><subject>Inflammasomes - metabolism</subject><subject>Inflammasomes - radiation effects</subject><subject>Inflammation - etiology</subject><subject>Models, Biological</subject><subject>Nervous System Diseases - etiology</subject><subject>NLR Family, Pyrin Domain-Containing 3 Protein - metabolism</subject><subject>NLRP3 inflammasome</subject><subject>Pandemics</subject><subject>Particle Size</subject><subject>Particulate Matter - adverse effects</subject><subject>Pneumonia - etiology</subject><subject>Pollution</subject><subject>Radioactivity</subject><subject>SARS-CoV-2 - pathogenicity</subject><issn>0306-9877</issn><issn>1532-2777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd-K1DAUh4Mo7rj6Al5IXqBj2rRJAyIsi_9gcGVHr0OanEwztMmQZAbnKXxl2627uDd7FTj5_b7D4UPobUnWJSnZ-_16hP68rkg1DUpCBXuGVmVDq6LinD9HK0IJK0TL-QV6ldKeECJq2r5EF5RWNWWsWaE_WzUCPoRhOGYXPE7hGDUkbEPEenCjyoB1r_wO8Oh2fcYd4P58gKh0dieVnd_h3AP-vrn9QbHzdlDjqFKYoMobDL-VhtgtOQ_HGO4jd9vmyPbqdovHELMaXD6_Ri-sGhK8-fdeol-fP_28_lpsbr58u77aFLpumlxoYk3JtSbQtcTWhvGOAwhrRQd1TUjDG9HUpWlFRxSvmbGGmtIqUVUd04rSS_Rx4R6O3QhGg89RDfIQp5PjWQbl5OMf73q5CyfJBaMtmQHVAtAxpBTBPnRLImc9ci9nPXLWIxc9U-nd_1sfKvc-psCHJQDT7ScHUSbtwGswLoLO0gT3FP8vxpOmvA</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Macias-Verde, David</creator><creator>Lara, Pedro C.</creator><creator>Burgos-Burgos, Javier</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20210101</creationdate><title>Same pollution sources for climate change might be hyperactivating the NLRP3 inflammasome and exacerbating neuroinflammation and SARS mortality</title><author>Macias-Verde, David ; 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| ispartof | Medical hypotheses, 2021-01, Vol.146, p.110396-110396, Article 110396 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aerosols Air Microbiology Air Pollution, Radioactive - adverse effects Alzheimer’s disease ARDS Causality Climate Change COVID-19 COVID-19 - etiology COVID-19 - mortality Humans Inflammasomes - metabolism Inflammasomes - radiation effects Inflammation - etiology Models, Biological Nervous System Diseases - etiology NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 inflammasome Pandemics Particle Size Particulate Matter - adverse effects Pneumonia - etiology Pollution Radioactivity SARS-CoV-2 - pathogenicity |
| title | Same pollution sources for climate change might be hyperactivating the NLRP3 inflammasome and exacerbating neuroinflammation and SARS mortality |
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