Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody

The recurrent zoonotic spillover of coronaviruses (CoVs) into the human population underscores the need for broadly active countermeasures. We employed a directed evolution approach to engineer three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies for enhanced neutralization...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2021-02, Vol.371 (6531), p.823-829
Hauptverfasser:	Rappazzo, C Garrett, Tse, Longping V, Kaku, Chengzi I, Wrapp, Daniel, Sakharkar, Mrunal, Huang, Deli, Deveau, Laura M, Yockachonis, Thomas J, Herbert, Andrew S, Battles, Michael B, O'Brien, Cecilia M, Brown, Michael E, Geoghegan, James C, Belk, Jonathan, Peng, Linghang, Yang, Linlin, Hou, Yixuan, Scobey, Trevor D, Burton, Dennis R, Nemazee, David, Dye, John M, Voss, James E, Gunn, Bronwyn M, McLellan, Jason S, Baric, Ralph S, Gralinski, Lisa E, Walker, Laura M
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Angiotensin-Converting Enzyme 2 - metabolism Animal models Animals Antibodies Antibodies, Monoclonal - genetics Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Antibodies, Viral - genetics Antibodies, Viral - immunology Antibodies, Viral - metabolism Antibody Affinity Betacoronavirus - immunology Binding Sites Binding Sites, Antibody Broadly Neutralizing Antibodies - genetics Broadly Neutralizing Antibodies - immunology Broadly Neutralizing Antibodies - metabolism Cell Surface Display Techniques Coronaviridae Coronaviruses COVID-19 COVID-19 - prevention & control COVID-19 - therapy COVID-19 Serotherapy Directed evolution Directed Molecular Evolution Domains Epidemics Epitopes Epitopes - immunology Human populations Humans Immunization, Passive Immunoglobulin Fc Fragments - immunology Immunology Lungs Mice Mice, Inbred BALB C Microbio Monoclonal antibodies Neutralization Pandemics Progeny Protein Domains Protein Engineering Receptors Receptors, Coronavirus - metabolism Respiratory diseases SARS-CoV-2 - immunology Severe acute respiratory syndrome Severe Acute Respiratory Syndrome - immunology Severe Acute Respiratory Syndrome - prevention & control Severe Acute Respiratory Syndrome - therapy Severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome-related coronavirus - immunology Spike Glycoprotein, Coronavirus - immunology Spike Glycoprotein, Coronavirus - metabolism Viral diseases Viruses Yeasts
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