Protective Effects of APOE ε2 Genotype on Cognition in Older Breast Cancer Survivors: The Thinking and Living With Cancer Study

Background Cancer-related cognitive decline (CRCD) has been linked to apolipoprotein E (APOE) gene ε4 polymorphisms. APOE ε4 polymorphisms are also the strongest genetic risk for late-onset Alzheimer disease (AD), whereas ε2 polymorphisms protect against AD. However, the effects of ε2 polymorphisms...

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Veröffentlicht in:	JNCI cancer spectrum 2021-04, Vol.5 (2)
Hauptverfasser:	Van Dyk, Kathleen, Zhou, Xingtao, Small, Brent J, Ahn, Jaeil, Zhai, Wanting, Ahles, Tim, Graham, Deena, Jacobsen, Paul B, Jim, Heather, McDonald, Brenna C, Nudelman Holohan, Kelly, Patel, Sunita K, Rebeck, G William, Root, James C, Saykin, Andrew J, Cohen, Harvey Jay, Mandelblatt, Jeanne S, Carroll, Judith E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - genetics Apolipoprotein E2 - genetics Apolipoprotein E4 - genetics Attention - physiology Breast Neoplasms - genetics Cancer Survivors Case-Control Studies Cognition - physiology Cognitive Dysfunction - genetics Executive Function - physiology Female Genotype Humans Learning - physiology Memory - physiology Middle Aged Neuropsychological Tests Polymorphism, Genetic
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