Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

Most human monoclonal antibodies (mAbs) neutralizing SARS-CoV-2 recognize the spike (S) protein receptor-binding domain and block virus interactions with the cellular receptor angiotensin-converting enzyme 2. We describe a panel of human mAbs binding to diverse epitopes on the N-terminal domain (NTD...

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Veröffentlicht in:	Cell 2021-04, Vol.184 (9), p.2316-2331.e15
Hauptverfasser:	Suryadevara, Naveenchandra, Shrihari, Swathi, Gilchuk, Pavlo, VanBlargan, Laura A., Binshtein, Elad, Zost, Seth J., Nargi, Rachel S., Sutton, Rachel E., Winkler, Emma S., Chen, Elaine C., Fouch, Mallorie E., Davidson, Edgar, Doranz, Benjamin J., Chen, Rita E., Shi, Pei-Yong, Carnahan, Robert H., Thackray, Larissa B., Diamond, Michael S., Crowe, James E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Antibodies, Neutralizing - pharmacology Binding, Competitive Chemokines - metabolism Chlorocebus aethiops coronavirus COVID-19 - immunology COVID-19 - virology HEK293 Cells Humans Immunoglobulin Fab Fragments - metabolism Immunoglobulin G - metabolism Lung - metabolism Mice Mice, Inbred C57BL Models, Molecular monoclonal antibodies Mutagenesis - genetics N-terminal domain Neutralization Tests neutralizing antibodies Protective Agents - pharmacology Protein Domains SARS-CoV-2 Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - immunology Vero Cells viral antibodies
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