Genetically Defined Oligodendroglioma Is Characterized by Indistinct Tumor Borders at MRI
In 2016, the World Health Organization revised the brain tumor classification, making mutation and 1p/19q codeletion the defining features of oligodendroglioma. To determine whether imaging characteristics previously associated with oligodendroglial tumors are still applicable, we evaluated the MR i...
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| Veröffentlicht in: | American journal of neuroradiology : AJNR 2017-04, Vol.38 (4), p.678-684 |
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| container_title | American journal of neuroradiology : AJNR |
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| creator | Johnson, D R Diehn, F E Giannini, C Jenkins, R B Jenkins, S M Parney, I F Kaufmann, T J |
| description | In 2016, the World Health Organization revised the brain tumor classification, making
mutation and 1p/19q codeletion the defining features of oligodendroglioma. To determine whether imaging characteristics previously associated with oligodendroglial tumors are still applicable, we evaluated the MR imaging features of genetically defined oligodendrogliomas.
One hundred forty-eight adult patients with untreated World Health Organization grade II and III infiltrating gliomas with histologic oligodendroglial morphology, known 1p/19q status, and at least 1 preoperative MR imaging were retrospectively identified. The association of 1p/19q codeletion with tumor imaging characteristics and ADC values was evaluated.
Ninety of 148 (61%) patients had 1p/19q codeleted tumors, corresponding to genetically defined oligodendroglioma, and 58/148 (39%) did not show 1p/19q codeletion, corresponding to astrocytic tumors. Eighty-three of 90 (92%) genetically defined oligodendrogliomas had noncircumscribed borders, compared with 26/58 (45%) non-1p/19q codeleted tumors with at least partial histologic oligodendroglial morphology (
< .0001). Eighty-nine of 90 (99%) oligodendrogliomas were heterogeneous on T1- and/or T2-weighted imaging. In patients with available ADC values, a lower mean ADC value predicted 1p/19q codeletion (
= .0005).
Imaging characteristics of World Health Organization 2016 genetically defined oligodendrogliomas differ from the previously considered characteristics of morphologically defined oligodendrogliomas. We found that genetically defined oligodendrogliomas were commonly poorly circumscribed and were almost always heterogeneous in signal intensity. |
| doi_str_mv | 10.3174/ajnr.A5070 |
| format | Article |
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mutation and 1p/19q codeletion the defining features of oligodendroglioma. To determine whether imaging characteristics previously associated with oligodendroglial tumors are still applicable, we evaluated the MR imaging features of genetically defined oligodendrogliomas.
One hundred forty-eight adult patients with untreated World Health Organization grade II and III infiltrating gliomas with histologic oligodendroglial morphology, known 1p/19q status, and at least 1 preoperative MR imaging were retrospectively identified. The association of 1p/19q codeletion with tumor imaging characteristics and ADC values was evaluated.
Ninety of 148 (61%) patients had 1p/19q codeleted tumors, corresponding to genetically defined oligodendroglioma, and 58/148 (39%) did not show 1p/19q codeletion, corresponding to astrocytic tumors. Eighty-three of 90 (92%) genetically defined oligodendrogliomas had noncircumscribed borders, compared with 26/58 (45%) non-1p/19q codeleted tumors with at least partial histologic oligodendroglial morphology (
< .0001). Eighty-nine of 90 (99%) oligodendrogliomas were heterogeneous on T1- and/or T2-weighted imaging. In patients with available ADC values, a lower mean ADC value predicted 1p/19q codeletion (
= .0005).
Imaging characteristics of World Health Organization 2016 genetically defined oligodendrogliomas differ from the previously considered characteristics of morphologically defined oligodendrogliomas. We found that genetically defined oligodendrogliomas were commonly poorly circumscribed and were almost always heterogeneous in signal intensity.</description><identifier>ISSN: 0195-6108</identifier><identifier>EISSN: 1936-959X</identifier><identifier>DOI: 10.3174/ajnr.A5070</identifier><identifier>PMID: 28126746</identifier><language>eng</language><publisher>United States: American Society of Neuroradiology</publisher><subject>Adult ; Adult Brain ; Aged ; Borders ; Brain ; Brain architecture ; Brain cancer ; Brain Neoplasms - diagnostic imaging ; Brain Neoplasms - genetics ; Brain Neoplasms - pathology ; Brain tumors ; Chromosomes, Human, Pair 1 ; Chromosomes, Human, Pair 19 ; Classification ; Fellows' Journal Club ; Female ; Health ; Humans ; Isocitrate Dehydrogenase - genetics ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Morphology ; Mutation ; Neuroimaging ; Oligodendroglioma ; Oligodendroglioma - diagnostic imaging ; Oligodendroglioma - genetics ; Oligodendroglioma - pathology ; Patients ; Physical characteristics ; Quality ; Retrospective Studies ; Tumors</subject><ispartof>American journal of neuroradiology : AJNR, 2017-04, Vol.38 (4), p.678-684</ispartof><rights>2017 by American Journal of Neuroradiology.</rights><rights>Copyright American Society of Neuroradiology Apr 2017</rights><rights>2017 by American Journal of Neuroradiology 2017 American Journal of Neuroradiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-fd259353ac6894c9879dd70502761ec818b56a552886506a5994c787be5696e33</citedby><cites>FETCH-LOGICAL-c439t-fd259353ac6894c9879dd70502761ec818b56a552886506a5994c787be5696e33</cites><orcidid>0000-0003-2757-6782 ; 0000-0002-4217-5517 ; 0000-0001-7483-1569 ; 0000-0002-4157-8066 ; 0000-0002-9702-8047 ; 0000-0001-9458-8017 ; 0000-0002-4049-694X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960254/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960254/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28126746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, D R</creatorcontrib><creatorcontrib>Diehn, F E</creatorcontrib><creatorcontrib>Giannini, C</creatorcontrib><creatorcontrib>Jenkins, R B</creatorcontrib><creatorcontrib>Jenkins, S M</creatorcontrib><creatorcontrib>Parney, I F</creatorcontrib><creatorcontrib>Kaufmann, T J</creatorcontrib><title>Genetically Defined Oligodendroglioma Is Characterized by Indistinct Tumor Borders at MRI</title><title>American journal of neuroradiology : AJNR</title><addtitle>AJNR Am J Neuroradiol</addtitle><description>In 2016, the World Health Organization revised the brain tumor classification, making
mutation and 1p/19q codeletion the defining features of oligodendroglioma. To determine whether imaging characteristics previously associated with oligodendroglial tumors are still applicable, we evaluated the MR imaging features of genetically defined oligodendrogliomas.
One hundred forty-eight adult patients with untreated World Health Organization grade II and III infiltrating gliomas with histologic oligodendroglial morphology, known 1p/19q status, and at least 1 preoperative MR imaging were retrospectively identified. The association of 1p/19q codeletion with tumor imaging characteristics and ADC values was evaluated.
Ninety of 148 (61%) patients had 1p/19q codeleted tumors, corresponding to genetically defined oligodendroglioma, and 58/148 (39%) did not show 1p/19q codeletion, corresponding to astrocytic tumors. Eighty-three of 90 (92%) genetically defined oligodendrogliomas had noncircumscribed borders, compared with 26/58 (45%) non-1p/19q codeleted tumors with at least partial histologic oligodendroglial morphology (
< .0001). Eighty-nine of 90 (99%) oligodendrogliomas were heterogeneous on T1- and/or T2-weighted imaging. In patients with available ADC values, a lower mean ADC value predicted 1p/19q codeletion (
= .0005).
Imaging characteristics of World Health Organization 2016 genetically defined oligodendrogliomas differ from the previously considered characteristics of morphologically defined oligodendrogliomas. We found that genetically defined oligodendrogliomas were commonly poorly circumscribed and were almost always heterogeneous in signal intensity.</description><subject>Adult</subject><subject>Adult Brain</subject><subject>Aged</subject><subject>Borders</subject><subject>Brain</subject><subject>Brain architecture</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - diagnostic imaging</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain tumors</subject><subject>Chromosomes, Human, Pair 1</subject><subject>Chromosomes, Human, Pair 19</subject><subject>Classification</subject><subject>Fellows' Journal Club</subject><subject>Female</subject><subject>Health</subject><subject>Humans</subject><subject>Isocitrate Dehydrogenase - genetics</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Mutation</subject><subject>Neuroimaging</subject><subject>Oligodendroglioma</subject><subject>Oligodendroglioma - diagnostic imaging</subject><subject>Oligodendroglioma - genetics</subject><subject>Oligodendroglioma - pathology</subject><subject>Patients</subject><subject>Physical characteristics</subject><subject>Quality</subject><subject>Retrospective Studies</subject><subject>Tumors</subject><issn>0195-6108</issn><issn>1936-959X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0U1rVDEUBuAgih2rG3-ABNxI4dZ83HxthDrVOlApSAVdhUxyZprh3qQm9wrjrze1tagrVwnk4eXkvAg9p-SYU9W_drtUjk8EUeQBWlDDZWeE-fIQLQg1opOU6AP0pNYdIUQYxR6jA6Ypk6qXC_T1DBJM0bth2ONT2MQEAV8McZsDpFDydoh5dHhV8fLKFecnKPFHI-s9XqUQ6xSTn_DlPOaC3-YSoFTsJvzx0-operRxQ4Vnd-ch-vz-3eXyQ3d-cbZanpx3vudm6jaBCcMFd15q03ujlQlBEUGYkhS8pnotpBOCaS0FaTfTlNJqDUIaCZwfoje3udfzeoTgIU3FDfa6xNGVvc0u2r9fUryy2_zdKiMJE30LeHUXUPK3Gepkx1g9DINLkOdqqTZUayqo-A8q29i9NKTRl__QXZ5Lapuw1GhKhGacNXV0q3zJtRbY3M9Nib0p196Ua3-V2_CLP396T3-3yX8CD9-fFw</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Johnson, D R</creator><creator>Diehn, F E</creator><creator>Giannini, C</creator><creator>Jenkins, R B</creator><creator>Jenkins, S M</creator><creator>Parney, I F</creator><creator>Kaufmann, T J</creator><general>American Society of Neuroradiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2757-6782</orcidid><orcidid>https://orcid.org/0000-0002-4217-5517</orcidid><orcidid>https://orcid.org/0000-0001-7483-1569</orcidid><orcidid>https://orcid.org/0000-0002-4157-8066</orcidid><orcidid>https://orcid.org/0000-0002-9702-8047</orcidid><orcidid>https://orcid.org/0000-0001-9458-8017</orcidid><orcidid>https://orcid.org/0000-0002-4049-694X</orcidid></search><sort><creationdate>201704</creationdate><title>Genetically Defined Oligodendroglioma Is Characterized by Indistinct Tumor Borders at MRI</title><author>Johnson, D R ; 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mutation and 1p/19q codeletion the defining features of oligodendroglioma. To determine whether imaging characteristics previously associated with oligodendroglial tumors are still applicable, we evaluated the MR imaging features of genetically defined oligodendrogliomas.
One hundred forty-eight adult patients with untreated World Health Organization grade II and III infiltrating gliomas with histologic oligodendroglial morphology, known 1p/19q status, and at least 1 preoperative MR imaging were retrospectively identified. The association of 1p/19q codeletion with tumor imaging characteristics and ADC values was evaluated.
Ninety of 148 (61%) patients had 1p/19q codeleted tumors, corresponding to genetically defined oligodendroglioma, and 58/148 (39%) did not show 1p/19q codeletion, corresponding to astrocytic tumors. Eighty-three of 90 (92%) genetically defined oligodendrogliomas had noncircumscribed borders, compared with 26/58 (45%) non-1p/19q codeleted tumors with at least partial histologic oligodendroglial morphology (
< .0001). Eighty-nine of 90 (99%) oligodendrogliomas were heterogeneous on T1- and/or T2-weighted imaging. In patients with available ADC values, a lower mean ADC value predicted 1p/19q codeletion (
= .0005).
Imaging characteristics of World Health Organization 2016 genetically defined oligodendrogliomas differ from the previously considered characteristics of morphologically defined oligodendrogliomas. We found that genetically defined oligodendrogliomas were commonly poorly circumscribed and were almost always heterogeneous in signal intensity.</abstract><cop>United States</cop><pub>American Society of Neuroradiology</pub><pmid>28126746</pmid><doi>10.3174/ajnr.A5070</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2757-6782</orcidid><orcidid>https://orcid.org/0000-0002-4217-5517</orcidid><orcidid>https://orcid.org/0000-0001-7483-1569</orcidid><orcidid>https://orcid.org/0000-0002-4157-8066</orcidid><orcidid>https://orcid.org/0000-0002-9702-8047</orcidid><orcidid>https://orcid.org/0000-0001-9458-8017</orcidid><orcidid>https://orcid.org/0000-0002-4049-694X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adult Brain Aged Borders Brain Brain architecture Brain cancer Brain Neoplasms - diagnostic imaging Brain Neoplasms - genetics Brain Neoplasms - pathology Brain tumors Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 19 Classification Fellows' Journal Club Female Health Humans Isocitrate Dehydrogenase - genetics Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Middle Aged Morphology Mutation Neuroimaging Oligodendroglioma Oligodendroglioma - diagnostic imaging Oligodendroglioma - genetics Oligodendroglioma - pathology Patients Physical characteristics Quality Retrospective Studies Tumors |
| title | Genetically Defined Oligodendroglioma Is Characterized by Indistinct Tumor Borders at MRI |
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