Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Clinical Isolates during 7.5 Years in One Regional Hospital in Israel
Background. The clonal repertoire of community-associated Methicillin-resistant Staphylococcus aureus (CA-MRSA) strains appear to differ between hospitals and geographic locations. We aimed to study the molecular epidemiology of MRSA infections in our regional hospital in Israel. Methods. A retrospe...
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| description | Background. The clonal repertoire of community-associated Methicillin-resistant Staphylococcus aureus (CA-MRSA) strains appear to differ between hospitals and geographic locations. We aimed to study the molecular epidemiology of MRSA infections in our regional hospital in Israel. Methods. A retrospective analysis of MRSA isolates from hospitalized patients, which underwent spa typing between 2012 and 2019. Mainly, MRSA-bloodstream isolates were typed. Isolates were grouped into healthcare-associated (HcA) or community-associated (CA). HcA were further divided into hospital-related or long-term care facility- (LTCF-) related. Several representatives underwent SCCmec typing. Results. We analyzed 166 clinical MRSA isolates: 115 (70%) bloodstream, 42 (25%) wounds/abscesses, and 9 (5%) screening isolates. 145 (87%) were HcA, and 21 (13%) were CA. Common (72%) spa types were t002, t032, t008, t001, and t065. Eighty (55%) isolates were attributed to LTCFs and 65 isolates to our hospital, both showing similar spa types distribution. The most prevalent spa type among patients with HcA infection was t002 (50 isolates, 32%), followed by t032, t065, t578, t008, and t001. Most (88/115, 77%) bloodstream infections (BSIs) were HcA, typically occurring in the same facility in which the infection was acquired. In 27 cases (23%), the BSI developed in the community setting, and in half of these cases, a previous healthcare system exposure was evident. Conclusions. The MRSA clonal population in this longitudinal study was stable and consisted mainly of molecular lineages widespread in Europe. SCCmec-IV strains play a major role in causing MRSA infections in the healthcare settings, especially in LTCFs. Community-acquired MRSA BSIs without any previous healthcare exposure are still relatively rare. |
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| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7960064</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A684191563</galeid><sourcerecordid>A684191563</sourcerecordid><originalsourceid>FETCH-LOGICAL-c504t-1c26656bd33e01158fdb2c01729e631185eb9a85b5b54e53e5168bc1488798fb3</originalsourceid><addsrcrecordid>eNp9kk1r3DAQhk1paT7aW89F0EuhdSJZlixdCmFJm4WEQNoeehKyPPYqaCVXslv2N-RPV8tutx-HoMMMzMOrmZe3KF4RfEYIY-cVrsg55zUlWDwpjgkXTSkFoU8PPWZHxUlK9xhzSZvqeXFEaVM3WIrj4uEmODCz0xFdjraDtQ0uDBsUenQD08oa65z15R0kmybtJ_R50uNq44IJxswJ6TlCLosMWaMdWqbg9AQJdXO0fkDNGUPfQMeErEe3HtAdDDb4TF6FNNopN3mwTFGDe1E867VL8HJfT4uvHy-_LK7K69tPy8XFdWkYrqeSmIpzxtuOUsDZAtF3bWUwaSoJnBIiGLRSC9bmVwOjwLIPrSG1EI0UfUtPiw873XFu19AZ8FPUTo3RrnXcqKCt-nfi7UoN4YdqJM8e1lng7V4ghu8zpEmtbTLgnPYQ5qQqhinPOwqc0Tf_ofdhjvn-HUVZRYj8Qw3agbK-D_lfsxVVF1xyWVNesccpURNJGKeZer-jTAwpRegPhxGstolR28SofWIy_vpvMw7w74hk4N0OWFnf6Z_2cblfe7bHXw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2503352119</pqid></control><display><type>article</type><title>Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Clinical Isolates during 7.5 Years in One Regional Hospital in Israel</title><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Cohen, Regev ; Paikin, Svetlana ; Finn, Talya ; Babushkin, Frida ; Anuka, Einav ; Baum, Moti ; Rokney, Assaf</creator><contributor>Dettori, Marco</contributor><creatorcontrib>Cohen, Regev ; Paikin, Svetlana ; Finn, Talya ; Babushkin, Frida ; Anuka, Einav ; Baum, Moti ; Rokney, Assaf ; Dettori, Marco</creatorcontrib><description>Background. The clonal repertoire of community-associated Methicillin-resistant Staphylococcus aureus (CA-MRSA) strains appear to differ between hospitals and geographic locations. We aimed to study the molecular epidemiology of MRSA infections in our regional hospital in Israel. Methods. A retrospective analysis of MRSA isolates from hospitalized patients, which underwent spa typing between 2012 and 2019. Mainly, MRSA-bloodstream isolates were typed. Isolates were grouped into healthcare-associated (HcA) or community-associated (CA). HcA were further divided into hospital-related or long-term care facility- (LTCF-) related. Several representatives underwent SCCmec typing. Results. We analyzed 166 clinical MRSA isolates: 115 (70%) bloodstream, 42 (25%) wounds/abscesses, and 9 (5%) screening isolates. 145 (87%) were HcA, and 21 (13%) were CA. Common (72%) spa types were t002, t032, t008, t001, and t065. Eighty (55%) isolates were attributed to LTCFs and 65 isolates to our hospital, both showing similar spa types distribution. The most prevalent spa type among patients with HcA infection was t002 (50 isolates, 32%), followed by t032, t065, t578, t008, and t001. Most (88/115, 77%) bloodstream infections (BSIs) were HcA, typically occurring in the same facility in which the infection was acquired. In 27 cases (23%), the BSI developed in the community setting, and in half of these cases, a previous healthcare system exposure was evident. Conclusions. The MRSA clonal population in this longitudinal study was stable and consisted mainly of molecular lineages widespread in Europe. SCCmec-IV strains play a major role in causing MRSA infections in the healthcare settings, especially in LTCFs. Community-acquired MRSA BSIs without any previous healthcare exposure are still relatively rare.</description><identifier>ISSN: 1687-9805</identifier><identifier>ISSN: 1687-9813</identifier><identifier>EISSN: 1687-9813</identifier><identifier>DOI: 10.1155/2021/6643108</identifier><identifier>PMID: 33747098</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Abscesses ; Adult ; Aged ; Aged, 80 and over ; Annual reports ; Clinical isolates ; Cloning ; Correlation analysis ; Drug resistance ; Drug resistance in microorganisms ; Epidemiology ; Exposure ; Female ; Geographical locations ; Health aspects ; Health care ; Hospitalization ; Hospitals ; Humans ; Infection ; Infections ; Israel - epidemiology ; Laboratories ; Long-term care ; Long-term care facilities ; Long-term care of the sick ; Male ; Medical records ; Medical research ; Medicine, Experimental ; Methicillin ; Methicillin-Resistant Staphylococcus aureus - genetics ; Methicillin-Resistant Staphylococcus aureus - isolation & purification ; Middle Aged ; Molecular Epidemiology ; Mupirocin ; Oxacillin ; Patients ; Pediatrics ; Population studies ; Public health ; Retrospective Studies ; Spas ; Staphylococcal Infections - epidemiology ; Staphylococcal Infections - microbiology ; Staphylococcus aureus ; Staphylococcus aureus infections ; Staphylococcus infections ; Surveillance ; Typing</subject><ispartof>Journal of environmental and public health, 2021, Vol.2021, p.6643108-9</ispartof><rights>Copyright © 2021 Regev Cohen et al.</rights><rights>COPYRIGHT 2021 John Wiley & Sons, Inc.</rights><rights>Copyright © 2021 Regev Cohen et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Regev Cohen et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-1c26656bd33e01158fdb2c01729e631185eb9a85b5b54e53e5168bc1488798fb3</citedby><cites>FETCH-LOGICAL-c504t-1c26656bd33e01158fdb2c01729e631185eb9a85b5b54e53e5168bc1488798fb3</cites><orcidid>0000-0001-7773-350X ; 0000-0002-3339-5876 ; 0000-0001-5028-2198 ; 0000-0002-7422-2402 ; 0000-0002-9114-7221 ; 0000-0002-5210-0711 ; 0000-0001-7955-8725</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960064/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960064/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33747098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Dettori, Marco</contributor><creatorcontrib>Cohen, Regev</creatorcontrib><creatorcontrib>Paikin, Svetlana</creatorcontrib><creatorcontrib>Finn, Talya</creatorcontrib><creatorcontrib>Babushkin, Frida</creatorcontrib><creatorcontrib>Anuka, Einav</creatorcontrib><creatorcontrib>Baum, Moti</creatorcontrib><creatorcontrib>Rokney, Assaf</creatorcontrib><title>Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Clinical Isolates during 7.5 Years in One Regional Hospital in Israel</title><title>Journal of environmental and public health</title><addtitle>J Environ Public Health</addtitle><description>Background. The clonal repertoire of community-associated Methicillin-resistant Staphylococcus aureus (CA-MRSA) strains appear to differ between hospitals and geographic locations. We aimed to study the molecular epidemiology of MRSA infections in our regional hospital in Israel. Methods. A retrospective analysis of MRSA isolates from hospitalized patients, which underwent spa typing between 2012 and 2019. Mainly, MRSA-bloodstream isolates were typed. Isolates were grouped into healthcare-associated (HcA) or community-associated (CA). HcA were further divided into hospital-related or long-term care facility- (LTCF-) related. Several representatives underwent SCCmec typing. Results. We analyzed 166 clinical MRSA isolates: 115 (70%) bloodstream, 42 (25%) wounds/abscesses, and 9 (5%) screening isolates. 145 (87%) were HcA, and 21 (13%) were CA. Common (72%) spa types were t002, t032, t008, t001, and t065. Eighty (55%) isolates were attributed to LTCFs and 65 isolates to our hospital, both showing similar spa types distribution. The most prevalent spa type among patients with HcA infection was t002 (50 isolates, 32%), followed by t032, t065, t578, t008, and t001. Most (88/115, 77%) bloodstream infections (BSIs) were HcA, typically occurring in the same facility in which the infection was acquired. In 27 cases (23%), the BSI developed in the community setting, and in half of these cases, a previous healthcare system exposure was evident. Conclusions. The MRSA clonal population in this longitudinal study was stable and consisted mainly of molecular lineages widespread in Europe. SCCmec-IV strains play a major role in causing MRSA infections in the healthcare settings, especially in LTCFs. Community-acquired MRSA BSIs without any previous healthcare exposure are still relatively rare.</description><subject>Abscesses</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Annual reports</subject><subject>Clinical isolates</subject><subject>Cloning</subject><subject>Correlation analysis</subject><subject>Drug resistance</subject><subject>Drug resistance in microorganisms</subject><subject>Epidemiology</subject><subject>Exposure</subject><subject>Female</subject><subject>Geographical locations</subject><subject>Health aspects</subject><subject>Health care</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infection</subject><subject>Infections</subject><subject>Israel - epidemiology</subject><subject>Laboratories</subject><subject>Long-term care</subject><subject>Long-term care facilities</subject><subject>Long-term care of the sick</subject><subject>Male</subject><subject>Medical records</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Methicillin</subject><subject>Methicillin-Resistant Staphylococcus aureus - genetics</subject><subject>Methicillin-Resistant Staphylococcus aureus - isolation & purification</subject><subject>Middle Aged</subject><subject>Molecular Epidemiology</subject><subject>Mupirocin</subject><subject>Oxacillin</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Population studies</subject><subject>Public health</subject><subject>Retrospective Studies</subject><subject>Spas</subject><subject>Staphylococcal Infections - epidemiology</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus infections</subject><subject>Staphylococcus infections</subject><subject>Surveillance</subject><subject>Typing</subject><issn>1687-9805</issn><issn>1687-9813</issn><issn>1687-9813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kk1r3DAQhk1paT7aW89F0EuhdSJZlixdCmFJm4WEQNoeehKyPPYqaCVXslv2N-RPV8tutx-HoMMMzMOrmZe3KF4RfEYIY-cVrsg55zUlWDwpjgkXTSkFoU8PPWZHxUlK9xhzSZvqeXFEaVM3WIrj4uEmODCz0xFdjraDtQ0uDBsUenQD08oa65z15R0kmybtJ_R50uNq44IJxswJ6TlCLosMWaMdWqbg9AQJdXO0fkDNGUPfQMeErEe3HtAdDDb4TF6FNNopN3mwTFGDe1E867VL8HJfT4uvHy-_LK7K69tPy8XFdWkYrqeSmIpzxtuOUsDZAtF3bWUwaSoJnBIiGLRSC9bmVwOjwLIPrSG1EI0UfUtPiw873XFu19AZ8FPUTo3RrnXcqKCt-nfi7UoN4YdqJM8e1lng7V4ghu8zpEmtbTLgnPYQ5qQqhinPOwqc0Tf_ofdhjvn-HUVZRYj8Qw3agbK-D_lfsxVVF1xyWVNesccpURNJGKeZer-jTAwpRegPhxGstolR28SofWIy_vpvMw7w74hk4N0OWFnf6Z_2cblfe7bHXw</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Cohen, Regev</creator><creator>Paikin, Svetlana</creator><creator>Finn, Talya</creator><creator>Babushkin, Frida</creator><creator>Anuka, Einav</creator><creator>Baum, Moti</creator><creator>Rokney, Assaf</creator><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7ST</scope><scope>7T2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>SOI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7773-350X</orcidid><orcidid>https://orcid.org/0000-0002-3339-5876</orcidid><orcidid>https://orcid.org/0000-0001-5028-2198</orcidid><orcidid>https://orcid.org/0000-0002-7422-2402</orcidid><orcidid>https://orcid.org/0000-0002-9114-7221</orcidid><orcidid>https://orcid.org/0000-0002-5210-0711</orcidid><orcidid>https://orcid.org/0000-0001-7955-8725</orcidid></search><sort><creationdate>2021</creationdate><title>Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Clinical Isolates during 7.5 Years in One Regional Hospital in Israel</title><author>Cohen, Regev ; Paikin, Svetlana ; Finn, Talya ; Babushkin, Frida ; Anuka, Einav ; Baum, Moti ; Rokney, Assaf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-1c26656bd33e01158fdb2c01729e631185eb9a85b5b54e53e5168bc1488798fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abscesses</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Annual reports</topic><topic>Clinical isolates</topic><topic>Cloning</topic><topic>Correlation analysis</topic><topic>Drug resistance</topic><topic>Drug resistance in microorganisms</topic><topic>Epidemiology</topic><topic>Exposure</topic><topic>Female</topic><topic>Geographical locations</topic><topic>Health aspects</topic><topic>Health care</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infection</topic><topic>Infections</topic><topic>Israel - epidemiology</topic><topic>Laboratories</topic><topic>Long-term care</topic><topic>Long-term care facilities</topic><topic>Long-term care of the sick</topic><topic>Male</topic><topic>Medical records</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Methicillin</topic><topic>Methicillin-Resistant Staphylococcus aureus - genetics</topic><topic>Methicillin-Resistant Staphylococcus aureus - isolation & purification</topic><topic>Middle Aged</topic><topic>Molecular Epidemiology</topic><topic>Mupirocin</topic><topic>Oxacillin</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Population studies</topic><topic>Public health</topic><topic>Retrospective Studies</topic><topic>Spas</topic><topic>Staphylococcal Infections - epidemiology</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus infections</topic><topic>Staphylococcus infections</topic><topic>Surveillance</topic><topic>Typing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cohen, Regev</creatorcontrib><creatorcontrib>Paikin, Svetlana</creatorcontrib><creatorcontrib>Finn, Talya</creatorcontrib><creatorcontrib>Babushkin, Frida</creatorcontrib><creatorcontrib>Anuka, Einav</creatorcontrib><creatorcontrib>Baum, Moti</creatorcontrib><creatorcontrib>Rokney, Assaf</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Environment Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Environmental Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of environmental and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cohen, Regev</au><au>Paikin, Svetlana</au><au>Finn, Talya</au><au>Babushkin, Frida</au><au>Anuka, Einav</au><au>Baum, Moti</au><au>Rokney, Assaf</au><au>Dettori, Marco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Clinical Isolates during 7.5 Years in One Regional Hospital in Israel</atitle><jtitle>Journal of environmental and public health</jtitle><addtitle>J Environ Public Health</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><spage>6643108</spage><epage>9</epage><pages>6643108-9</pages><issn>1687-9805</issn><issn>1687-9813</issn><eissn>1687-9813</eissn><abstract>Background. The clonal repertoire of community-associated Methicillin-resistant Staphylococcus aureus (CA-MRSA) strains appear to differ between hospitals and geographic locations. We aimed to study the molecular epidemiology of MRSA infections in our regional hospital in Israel. Methods. A retrospective analysis of MRSA isolates from hospitalized patients, which underwent spa typing between 2012 and 2019. Mainly, MRSA-bloodstream isolates were typed. Isolates were grouped into healthcare-associated (HcA) or community-associated (CA). HcA were further divided into hospital-related or long-term care facility- (LTCF-) related. Several representatives underwent SCCmec typing. Results. We analyzed 166 clinical MRSA isolates: 115 (70%) bloodstream, 42 (25%) wounds/abscesses, and 9 (5%) screening isolates. 145 (87%) were HcA, and 21 (13%) were CA. Common (72%) spa types were t002, t032, t008, t001, and t065. Eighty (55%) isolates were attributed to LTCFs and 65 isolates to our hospital, both showing similar spa types distribution. The most prevalent spa type among patients with HcA infection was t002 (50 isolates, 32%), followed by t032, t065, t578, t008, and t001. Most (88/115, 77%) bloodstream infections (BSIs) were HcA, typically occurring in the same facility in which the infection was acquired. In 27 cases (23%), the BSI developed in the community setting, and in half of these cases, a previous healthcare system exposure was evident. Conclusions. The MRSA clonal population in this longitudinal study was stable and consisted mainly of molecular lineages widespread in Europe. SCCmec-IV strains play a major role in causing MRSA infections in the healthcare settings, especially in LTCFs. Community-acquired MRSA BSIs without any previous healthcare exposure are still relatively rare.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>33747098</pmid><doi>10.1155/2021/6643108</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7773-350X</orcidid><orcidid>https://orcid.org/0000-0002-3339-5876</orcidid><orcidid>https://orcid.org/0000-0001-5028-2198</orcidid><orcidid>https://orcid.org/0000-0002-7422-2402</orcidid><orcidid>https://orcid.org/0000-0002-9114-7221</orcidid><orcidid>https://orcid.org/0000-0002-5210-0711</orcidid><orcidid>https://orcid.org/0000-0001-7955-8725</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of environmental and public health, 2021, Vol.2021, p.6643108-9 |
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| source | MEDLINE; Wiley Online Library Open Access; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Abscesses Adult Aged Aged, 80 and over Annual reports Clinical isolates Cloning Correlation analysis Drug resistance Drug resistance in microorganisms Epidemiology Exposure Female Geographical locations Health aspects Health care Hospitalization Hospitals Humans Infection Infections Israel - epidemiology Laboratories Long-term care Long-term care facilities Long-term care of the sick Male Medical records Medical research Medicine, Experimental Methicillin Methicillin-Resistant Staphylococcus aureus - genetics Methicillin-Resistant Staphylococcus aureus - isolation & purification Middle Aged Molecular Epidemiology Mupirocin Oxacillin Patients Pediatrics Population studies Public health Retrospective Studies Spas Staphylococcal Infections - epidemiology Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus aureus infections Staphylococcus infections Surveillance Typing |
| title | Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Clinical Isolates during 7.5 Years in One Regional Hospital in Israel |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T14%3A00%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Molecular%20Epidemiology%20of%20Methicillin-Resistant%20Staphylococcus%20aureus%20Clinical%20Isolates%20during%207.5%20Years%20in%20One%20Regional%20Hospital%20in%20Israel&rft.jtitle=Journal%20of%20environmental%20and%20public%20health&rft.au=Cohen,%20Regev&rft.date=2021&rft.volume=2021&rft.spage=6643108&rft.epage=9&rft.pages=6643108-9&rft.issn=1687-9805&rft.eissn=1687-9813&rft_id=info:doi/10.1155/2021/6643108&rft_dat=%3Cgale_pubme%3EA684191563%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2503352119&rft_id=info:pmid/33747098&rft_galeid=A684191563&rfr_iscdi=true |