A Novel 1,8-Naphthyridine-2-Carboxamide Derivative Attenuates Inflammatory Responses and Cell Migration in LPS-Treated BV2 Cells via the Suppression of ROS Generation and TLR4/Myd88/NF-κB Signaling Pathway

Novel 1,8-naphthyridine-2-carboxamide derivatives with various substituents (HSR2101-HSR2113) were synthesized and evaluated for their effects on the production of pro-inflammatory mediators and cell migration in lipopolysaccharide (LPS)-treated BV2 microglial cells. Among the tested compounds, HSR2...

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Veröffentlicht in:	International journal of molecular sciences 2021-03, Vol.22 (5), p.2527
Hauptverfasser:	Nguyen, Phuong Linh, Bui, Bich Phuong, Lee, Heesoon, Cho, Jungsook
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Cell adhesion & migration Cell Movement - drug effects Cells, Cultured Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Cytokines Cytotoxicity Inflammation Inflammation Mediators - pharmacology Inhibitors Interleukin 6 Lipopolysaccharides Lipopolysaccharides - pharmacology MAP Kinase Signaling System - drug effects Mice Microglia Microglia - drug effects Microglia - metabolism MyD88 protein Myeloid Differentiation Factor 88 - metabolism Naphthyridines - pharmacology Neurodegeneration NF-kappa B - metabolism NF-κB protein Nitric oxide Nitric Oxide - metabolism Nitric-oxide synthase Nuclear transport Phosphorylation Reactive oxygen species Reactive Oxygen Species - metabolism Signal transduction Signal Transduction - drug effects TLR4 protein Toll-Like Receptor 4 - metabolism Toll-like receptors Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α Wound healing
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