Rotavirus induces intercellular calcium waves through ADP signaling

Rotavirus causes severe diarrheal disease in children by broadly dysregulating intestinal homeostasis. However, the underlying mechanism(s) of rotavirus-induced dysregulation remains unclear. We found that rotavirus-infected cells produce paracrine signals that manifested as intercellular calcium wa...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2020-11, Vol.370 (6519)
Hauptverfasser:	Chang-Graham, Alexandra L, Perry, Jacob L, Engevik, Melinda A, Engevik, Kristen A, Scribano, Francesca J, Gebert, J Thomas, Danhof, Heather A, Nelson, Joel C, Kellen, Joseph S, Strtak, Alicia C, Sastri, Narayan P, Estes, Mary K, Britton, Robert A, Versalovic, James, Hyser, Joseph M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine diphosphate Adenosine Diphosphate - metabolism Adenosine triphosphate Amplification Animals Antagonists Apyrase Biotechnology Calcium Calcium - metabolism Calcium chloride Calcium imaging Calcium Signaling - drug effects Calcium Signaling - genetics Calcium Signaling - physiology Calcium signalling Cell lines Cell signaling Children CRISPR Cyclooxygenase-2 Diarrhea Disease Drug development Drug therapy Enterocytes Epithelial cells Female Fluorescence HEK293 Cells Homeostasis Humans Infections Intestine Jejunum - metabolism Jejunum - virology Male Mice Mice, Inbred C57BL Mice, Knockout Neonates Nitric oxide Nitric-oxide synthase Paracrine Communication Paracrine signalling Pathogenesis Pathophysiology Prostaglandins Purinergic P2Y Receptor Antagonists - pharmacology Receptors Receptors, Purinergic P2Y1 - genetics Receptors, Purinergic P2Y1 - metabolism Replication Rotavirus Rotavirus - physiology Rotavirus Infections - metabolism Secretion Serotonin Signal transduction Signaling Small intestine Viruses Vomiting
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