Synthesis of HDAC Inhibitor Libraries via Microscale Workflow

An integrated workflow has been established that enables the synthesis, purification, and subsequent biological testing of compound libraries on a microgram scale. This approach utilizes mass directed preparative HPLC in conjunction with charged aerosol detection (CAD) to generate solutions of inves...

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Veröffentlicht in:	ACS medicinal chemistry letters 2021-03, Vol.12 (3), p.337-342
Hauptverfasser:	Dykstra, Kevin D, Streckfuss, Eric, Liu, Min, Liu, Jian, Yu, Younong, Wang, Ming, Kozlowski, Joseph A, Myers, Robert W, Buevich, Alexei V, Maletic, Milana M, Vachal, Petr, Krska, Shane W
Format:	Artikel
Sprache:	eng
Schlagworte:	Innovations
Online-Zugang:	Volltext
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