Calcium Sulfate and Plasma Rich in Growth Factors Enhance Bone Regeneration after Extraction of the Mandibular Third Molar: A Proof of Concept Study
The aim of this study was to evaluate the mixture of Calcium Sulfate and Plasma Rich in Growth Factors (CaSO + PRGF) as a bone-graft substitute in extracted mandibular third molar (MTM) alveoli during a 4-month period. Bilateral MTM extractions were performed in 10 patients (18-25 years) at the Oral...
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| Veröffentlicht in: | Materials 2021-02, Vol.14 (5), p.1126 |
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| creator | Huchim-Chablé, María de Arredondo, Roberto Sosa-Martínez Rivero-Navarrete, José Alberto Mendiburu-Zavala, Celia Cárdenas-Erosa, Rubén Peñaloza-Cuevas, Ricardo |
| description | The aim of this study was to evaluate the mixture of Calcium Sulfate and Plasma Rich in Growth Factors (CaSO
+ PRGF) as a bone-graft substitute in extracted mandibular third molar (MTM) alveoli during a 4-month period. Bilateral MTM extractions were performed in 10 patients (18-25 years) at the Oral-Surgery-Clinic of the Universidad Autónoma de Yucatán (UADY). A CaSO
+ PRGF mixture was placed in the right alveolus (Experimental Group (EG)) and a natural blood clot in the left (Control Group (CG)). Monthly X-ray controls were performed using a gray scale to measure Bone Regeneration (BR). A non-parametric Sign Test was used to evaluate Radiopacity/Bone Regeneration (Ro/BR) over 4 months, and a Friedman's non-parametric test was used for intra-group analysis over these months. The study was approved by the Centro de Investigaciones Regionales (Dr. Hideyo Noguchi, UADY Bioethics Committee, ID 0026-2015). Using a non-parametric test of the sign, the EG showed significant difference of Ro/BR between groups
= 0.002 (
< 0.05). Significant differences were observed in all quadrants and areas
= 0.002 (
< 0.05) except in area A in month 4 (
= 0.016), which could be explained by its being the closest to native bone. EG CaSO
+ PRGF showed a higher degree of bone regeneration compared to CG. |
| doi_str_mv | 10.3390/ma14051126 |
| format | Article |
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+ PRGF) as a bone-graft substitute in extracted mandibular third molar (MTM) alveoli during a 4-month period. Bilateral MTM extractions were performed in 10 patients (18-25 years) at the Oral-Surgery-Clinic of the Universidad Autónoma de Yucatán (UADY). A CaSO
+ PRGF mixture was placed in the right alveolus (Experimental Group (EG)) and a natural blood clot in the left (Control Group (CG)). Monthly X-ray controls were performed using a gray scale to measure Bone Regeneration (BR). A non-parametric Sign Test was used to evaluate Radiopacity/Bone Regeneration (Ro/BR) over 4 months, and a Friedman's non-parametric test was used for intra-group analysis over these months. The study was approved by the Centro de Investigaciones Regionales (Dr. Hideyo Noguchi, UADY Bioethics Committee, ID 0026-2015). Using a non-parametric test of the sign, the EG showed significant difference of Ro/BR between groups
= 0.002 (
< 0.05). Significant differences were observed in all quadrants and areas
= 0.002 (
< 0.05) except in area A in month 4 (
= 0.016), which could be explained by its being the closest to native bone. EG CaSO
+ PRGF showed a higher degree of bone regeneration compared to CG.</description><identifier>ISSN: 1996-1944</identifier><identifier>EISSN: 1996-1944</identifier><identifier>DOI: 10.3390/ma14051126</identifier><identifier>PMID: 33673695</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alveoli ; Angiogenesis ; Calcium sulfate ; Cell adhesion & migration ; Dentistry ; Evaluation ; Fibroblasts ; Growth factors ; Hydroxyapatite ; Patients ; Plasma ; Quadrants ; Radiopacity ; Regeneration (physiology) ; Substitute bone ; X-rays</subject><ispartof>Materials, 2021-02, Vol.14 (5), p.1126</ispartof><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-a9da4b234e3a8483c7903d1c290514c1d9e07ae14d2264af2f74249058ca442c3</citedby><cites>FETCH-LOGICAL-c406t-a9da4b234e3a8483c7903d1c290514c1d9e07ae14d2264af2f74249058ca442c3</cites><orcidid>0000-0003-1613-6108</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957751/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957751/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33673695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huchim-Chablé, María</creatorcontrib><creatorcontrib>de Arredondo, Roberto Sosa-Martínez</creatorcontrib><creatorcontrib>Rivero-Navarrete, José Alberto</creatorcontrib><creatorcontrib>Mendiburu-Zavala, Celia</creatorcontrib><creatorcontrib>Cárdenas-Erosa, Rubén</creatorcontrib><creatorcontrib>Peñaloza-Cuevas, Ricardo</creatorcontrib><title>Calcium Sulfate and Plasma Rich in Growth Factors Enhance Bone Regeneration after Extraction of the Mandibular Third Molar: A Proof of Concept Study</title><title>Materials</title><addtitle>Materials (Basel)</addtitle><description>The aim of this study was to evaluate the mixture of Calcium Sulfate and Plasma Rich in Growth Factors (CaSO
+ PRGF) as a bone-graft substitute in extracted mandibular third molar (MTM) alveoli during a 4-month period. Bilateral MTM extractions were performed in 10 patients (18-25 years) at the Oral-Surgery-Clinic of the Universidad Autónoma de Yucatán (UADY). A CaSO
+ PRGF mixture was placed in the right alveolus (Experimental Group (EG)) and a natural blood clot in the left (Control Group (CG)). Monthly X-ray controls were performed using a gray scale to measure Bone Regeneration (BR). A non-parametric Sign Test was used to evaluate Radiopacity/Bone Regeneration (Ro/BR) over 4 months, and a Friedman's non-parametric test was used for intra-group analysis over these months. The study was approved by the Centro de Investigaciones Regionales (Dr. Hideyo Noguchi, UADY Bioethics Committee, ID 0026-2015). Using a non-parametric test of the sign, the EG showed significant difference of Ro/BR between groups
= 0.002 (
< 0.05). Significant differences were observed in all quadrants and areas
= 0.002 (
< 0.05) except in area A in month 4 (
= 0.016), which could be explained by its being the closest to native bone. EG CaSO
+ PRGF showed a higher degree of bone regeneration compared to CG.</description><subject>Alveoli</subject><subject>Angiogenesis</subject><subject>Calcium sulfate</subject><subject>Cell adhesion & migration</subject><subject>Dentistry</subject><subject>Evaluation</subject><subject>Fibroblasts</subject><subject>Growth factors</subject><subject>Hydroxyapatite</subject><subject>Patients</subject><subject>Plasma</subject><subject>Quadrants</subject><subject>Radiopacity</subject><subject>Regeneration (physiology)</subject><subject>Substitute bone</subject><subject>X-rays</subject><issn>1996-1944</issn><issn>1996-1944</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkd1qFTEUhQdRbGl74wPIBm9EOHbyMz_xQqiH0yq0WNp6HfbJ7OmkzCSnSUbte_jA5tBaqyGQTfbH2itZRfGKle-FUOXhhEyWFWO8flbsMqXqBVNSPn9S7xQHMd6UeQnBWq5eFjtC1I2oVbVb_FriaOw8weU89pgI0HVwPmKcEC6sGcA6OAn-RxrgGE3yIcLKDegMwSfvCC7omhwFTNY7wD5RgNXPFDK6vfA9pIHgLIva9TxigKvBhg7OfK4_wBGcB5-ZvJc-S24SXKa5u9svXvQ4Rjp4OPeKb8erq-XnxenXky_Lo9OFkWWdFqg6lGsuJAlsZStMo0rRMcNV_hBpWKeobJCY7DivJfa8bySXudkalJIbsVd8vNfdzOuJOkMuOx_1JtgJw532aPW_HWcHfe2_60ZVTVOxLPD2QSD425li0pONhsYRHfk56jytzQM536Jv_kNv_Bxcft6Wqpu6Uopn6t09ZYKPMVD_aIaVepu3_pt3hl8_tf-I_klX_AbUAKXU</recordid><startdate>20210227</startdate><enddate>20210227</enddate><creator>Huchim-Chablé, María</creator><creator>de Arredondo, Roberto Sosa-Martínez</creator><creator>Rivero-Navarrete, José Alberto</creator><creator>Mendiburu-Zavala, Celia</creator><creator>Cárdenas-Erosa, Rubén</creator><creator>Peñaloza-Cuevas, Ricardo</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1613-6108</orcidid></search><sort><creationdate>20210227</creationdate><title>Calcium Sulfate and Plasma Rich in Growth Factors Enhance Bone Regeneration after Extraction of the Mandibular Third Molar: A Proof of Concept Study</title><author>Huchim-Chablé, María ; de Arredondo, Roberto Sosa-Martínez ; Rivero-Navarrete, José Alberto ; Mendiburu-Zavala, Celia ; Cárdenas-Erosa, Rubén ; Peñaloza-Cuevas, Ricardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-a9da4b234e3a8483c7903d1c290514c1d9e07ae14d2264af2f74249058ca442c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alveoli</topic><topic>Angiogenesis</topic><topic>Calcium sulfate</topic><topic>Cell adhesion & migration</topic><topic>Dentistry</topic><topic>Evaluation</topic><topic>Fibroblasts</topic><topic>Growth factors</topic><topic>Hydroxyapatite</topic><topic>Patients</topic><topic>Plasma</topic><topic>Quadrants</topic><topic>Radiopacity</topic><topic>Regeneration (physiology)</topic><topic>Substitute bone</topic><topic>X-rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huchim-Chablé, María</creatorcontrib><creatorcontrib>de Arredondo, Roberto Sosa-Martínez</creatorcontrib><creatorcontrib>Rivero-Navarrete, José Alberto</creatorcontrib><creatorcontrib>Mendiburu-Zavala, Celia</creatorcontrib><creatorcontrib>Cárdenas-Erosa, Rubén</creatorcontrib><creatorcontrib>Peñaloza-Cuevas, Ricardo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huchim-Chablé, María</au><au>de Arredondo, Roberto Sosa-Martínez</au><au>Rivero-Navarrete, José Alberto</au><au>Mendiburu-Zavala, Celia</au><au>Cárdenas-Erosa, Rubén</au><au>Peñaloza-Cuevas, Ricardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calcium Sulfate and Plasma Rich in Growth Factors Enhance Bone Regeneration after Extraction of the Mandibular Third Molar: A Proof of Concept Study</atitle><jtitle>Materials</jtitle><addtitle>Materials (Basel)</addtitle><date>2021-02-27</date><risdate>2021</risdate><volume>14</volume><issue>5</issue><spage>1126</spage><pages>1126-</pages><issn>1996-1944</issn><eissn>1996-1944</eissn><abstract>The aim of this study was to evaluate the mixture of Calcium Sulfate and Plasma Rich in Growth Factors (CaSO
+ PRGF) as a bone-graft substitute in extracted mandibular third molar (MTM) alveoli during a 4-month period. Bilateral MTM extractions were performed in 10 patients (18-25 years) at the Oral-Surgery-Clinic of the Universidad Autónoma de Yucatán (UADY). A CaSO
+ PRGF mixture was placed in the right alveolus (Experimental Group (EG)) and a natural blood clot in the left (Control Group (CG)). Monthly X-ray controls were performed using a gray scale to measure Bone Regeneration (BR). A non-parametric Sign Test was used to evaluate Radiopacity/Bone Regeneration (Ro/BR) over 4 months, and a Friedman's non-parametric test was used for intra-group analysis over these months. The study was approved by the Centro de Investigaciones Regionales (Dr. Hideyo Noguchi, UADY Bioethics Committee, ID 0026-2015). Using a non-parametric test of the sign, the EG showed significant difference of Ro/BR between groups
= 0.002 (
< 0.05). Significant differences were observed in all quadrants and areas
= 0.002 (
< 0.05) except in area A in month 4 (
= 0.016), which could be explained by its being the closest to native bone. EG CaSO
+ PRGF showed a higher degree of bone regeneration compared to CG.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33673695</pmid><doi>10.3390/ma14051126</doi><orcidid>https://orcid.org/0000-0003-1613-6108</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1996-1944 1996-1944 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7957751 |
| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Alveoli Angiogenesis Calcium sulfate Cell adhesion & migration Dentistry Evaluation Fibroblasts Growth factors Hydroxyapatite Patients Plasma Quadrants Radiopacity Regeneration (physiology) Substitute bone X-rays |
| title | Calcium Sulfate and Plasma Rich in Growth Factors Enhance Bone Regeneration after Extraction of the Mandibular Third Molar: A Proof of Concept Study |
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