Anti-Tumor Effects of a Penetratin Peptide Targeting Transcription of E2F-1, 2 and 3a Is Enhanced When Used in Combination with Pemetrexed or Cisplatin

We tested the antitumor effects of a modified E2F peptide substituting D-Arg for L-Arg, conjugated to penetratin (PEP) against solid tumor cell lines and the CCRF-leukemia cell line, alone and in combination with pemetrexed or with cisplatin. For - studies, the peptide was encapsulated in PEGylated...

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Veröffentlicht in:	Cancers 2021-02, Vol.13 (5), p.972
Hauptverfasser:	Rather, Gulam Mohmad, Anyanwu, Michael, Minko, Tamara, Garbuzenko, Olga, Szekely, Zoltan, Bertino, Joseph R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Antitumor activity Apoptosis Breast cancer Cell cycle Cell growth Cisplatin Deoxyribonucleic acid Dihydrofolate reductase DNA DNA damage DNA repair E2F protein E2F1 protein Enzymes Gene amplification Kinases Lung cancer Lymphoma Mutation Non-small cell lung carcinoma Peptides Phosphorylation Prostate Prostate cancer Proteins Small cell lung carcinoma Solid tumors Thymidine Thymidine kinase Thymidylate synthase Transcription Tumor cell lines Tumors Xenografts
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