Plasmacytoid dendritic cell expansion defines a distinct subset of RUNX1-mutated acute myeloid leukemia

Plasmacytoid dendritic cells (pDCs) are the principal natural type I interferon–producing dendritic cells. Neoplastic expansion of pDCs and pDC precursors leads to blastic plasmacytoid dendritic cell neoplasm (BPDCN), and clonal expansion of mature pDCs has been described in chronic myelomonocytic l...

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Veröffentlicht in:	Blood 2021-03, Vol.137 (10), p.1377-1391
Hauptverfasser:	Xiao, Wenbin, Chan, Alexander, Waarts, Michael R., Mishra, Tanmay, Liu, Ying, Cai, Sheng F., Yao, Jinjuan, Gao, Qi, Bowman, Robert L., Koche, Richard P., Csete, Isabelle S., DelGaudio, Nicole L., Derkach, Andriy, Baik, Jeeyeon, Yanis, Sophia, Famulare, Christopher A., Patel, Minal, Arcila, Maria E., Stahl, Maximilian, Rampal, Raajit K., Tallman, Martin S., Zhang, Yanming, Dogan, Ahmet, Goldberg, Aaron D., Roshal, Mikhail, Levine, Ross L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Blast Crisis - genetics Blast Crisis - pathology Core Binding Factor Alpha 2 Subunit - genetics Dendritic Cells - metabolism Dendritic Cells - pathology Female Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Male Middle Aged Mutation Myeloid Neoplasia
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