Functional alterations caused by mutations reflect evolutionary trends of SARS-CoV-2

Abstract Since the first report of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019, the COVID-19 pandemic has spread rapidly worldwide. Due to the limited virus strains, few key mutations that would be very important with the evolutionary trends of virus genome were obs...

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Veröffentlicht in:	Briefings in bioinformatics 2021-03, Vol.22 (2), p.1442-1450
Hauptverfasser:	Cheng, Liang, Han, Xudong, Zhu, Zijun, Qi, Changlu, Wang, Ping, Zhang, Xue
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Angiotensin-converting enzyme 2 Antibodies Biological Evolution Case Study Coronaviruses COVID-19 COVID-19 - virology Evolution Functional analysis Genomes Humans Infectivity Linkage Disequilibrium Mutation Nucleotide sequence Open Reading Frames Pandemics Positive selection Proteins Reduction SARS-CoV-2 - genetics SARS-CoV-2 - pathogenicity Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike protein Stability analysis Strains (organisms) Trends Viral diseases Virulence Virulence - genetics Viruses
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