Interleukin-17-induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with an immunosuppressive microenvironment that is resistant to most therapies. IL17 is involved in pancreatic tumorigenesis, but its role in invasive PDAC is undetermined. We hypothesized that IL17 triggers and sustains PDAC immuno...

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Veröffentlicht in:	The Journal of experimental medicine 2020-12, Vol.217 (12)
Hauptverfasser:	Zhang, Yu, Chandra, Vidhi, Riquelme Sanchez, Erick, Dutta, Prasanta, Quesada, Pompeyo R, Rakoski, Amanda, Zoltan, Michelle, Arora, Nivedita, Baydogan, Seyda, Horne, William, Burks, Jared, Xu, Hanwen, Hussain, Perwez, Wang, Huamin, Gupta, Sonal, Maitra, Anirban, Bailey, Jennifer M, Moghaddam, Seyed J, Banerjee, Sulagna, Sahin, Ismet, Bhattacharya, Pratip, McAllister, Florencia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor - metabolism CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Drug Resistance, Neoplasm - drug effects Extracellular Traps - metabolism Humans Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use Immunosuppression Innate immunity and inflammation Interleukin-17 - pharmacology Lymphocyte Activation - drug effects Mice, Inbred C57BL Neutrophils - drug effects Neutrophils - pathology Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - immunology Pancreatic Neoplasms - pathology Programmed Cell Death 1 Receptor - metabolism Signal Transduction - drug effects Solid Tumors Tumor immunology Tumor Microenvironment - drug effects
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