APOBEC3A catalyzes mutation and drives carcinogenesis in vivo

The APOBEC3 family of antiviral DNA cytosine deaminases is implicated as the second largest source of mutation in cancer. This mutational process may be a causal driver or inconsequential passenger to the overall tumor phenotype. We show that human APOBEC3A expression in murine colon and liver tissu...

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Veröffentlicht in:	The Journal of experimental medicine 2020-12, Vol.217 (12)
Hauptverfasser:	Law, Emily K, Levin-Klein, Rena, Jarvis, Matthew C, Kim, Hyoung, Argyris, Prokopios P, Carpenter, Michael A, Starrett, Gabriel J, Temiz, Nuri A, Larson, Lindsay K, Durfee, Cameron, Burns, Michael B, Vogel, Rachel I, Stavrou, Spyridon, Aguilera, Alexya N, Wagner, Sandra, Largaespada, David A, Starr, Timothy K, Ross, Susan R, Harris, Reuben S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous Polyposis Coli - pathology Animals Base Sequence Biocatalysis Carcinogenesis - genetics Carcinogenesis - pathology Cytidine Deaminase - genetics DNA Transposable Elements - genetics Genome stability Humans Hydrolases - genetics Infectious disease and host defense Intestinal Neoplasms - pathology Liver Neoplasms - genetics Liver Neoplasms - pathology Liver Regeneration Loss of Heterozygosity - genetics Mice, Transgenic Mutation - genetics Polyps - pathology Proteins - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Solid Tumors
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