A network of immune and microbial modifications underlies viral persistence in the gastrointestinal tract

Many pathogens subvert intestinal immunity to persist within the gastrointestinal tract (GIT); yet, the underlying mechanisms that enable sanctuary specifically in this reservoir are unclear. Using mass cytometry and network analysis, we demonstrate that chronic LCMV infection of the GIT leads to dy...

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Veröffentlicht in:	The Journal of experimental medicine 2020-12, Vol.217 (12)
Hauptverfasser:	Macleod, Bethany L, Elsaesser, Heidi J, Snell, Laura M, Dickson, Russell J, Guo, Mengdi, Hezaveh, Kebria, Xu, Wenxi, Kothari, Akash, McGaha, Tracy L, Guidos, Cynthia J, Brooks, David G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bystander Effect CD8-Positive T-Lymphocytes - immunology Chronic Disease Colitis - complications Colitis - virology Dysbiosis - complications Dysbiosis - virology Gastrointestinal Tract - immunology Gastrointestinal Tract - microbiology Gastrointestinal Tract - pathology Gastrointestinal Tract - virology Gene Expression Regulation Infectious Disease and Host Defense Innate Immunity and Inflammation Lymphocyte Activation - immunology Lymphocyte Depletion Lymphocytic Choriomeningitis - genetics Lymphocytic Choriomeningitis - immunology Lymphocytic Choriomeningitis - virology Lymphocytic choriomeningitis virus - physiology Mice, Inbred C57BL Mucosal Immunology Phenotype T-Lymphocytes, Regulatory - immunology Technical Advances and Resources Transcriptome - genetics
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