Targeting mechanosensitive MDM4 promotes lung fibrosis resolution in aged mice

Aging is a strong risk factor and an independent prognostic factor for progressive human idiopathic pulmonary fibrosis (IPF). Aged mice develop nonresolving pulmonary fibrosis following lung injury. In this study, we found that mouse double minute 4 homolog (MDM4) is highly expressed in the fibrotic...

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Veröffentlicht in:	The Journal of experimental medicine 2021-05, Vol.218 (5)
Hauptverfasser:	Qu, Jing, Yang, Shan-Zhong, Zhu, Yi, Guo, Ting, Thannickal, Victor J, Zhou, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aging Animals Bleomycin Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cells, Cultured Estrogen Antagonists - pharmacology Extracellular Matrix - chemistry Extracellular Matrix - metabolism Fibroblasts - drug effects Fibroblasts - metabolism Fibrosis - chemically induced Fibrosis - genetics Fibrosis - prevention & control Human Disease Genetics Humans Idiopathic Pulmonary Fibrosis - genetics Idiopathic Pulmonary Fibrosis - metabolism Idiopathic Pulmonary Fibrosis - pathology Lung - drug effects Lung - metabolism Lung - pathology Mice Mice, Inbred C57BL Mice, Knockout Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism RNA Interference Stress, Mechanical Tamoxifen - pharmacology
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