Prolonged viral clearance of severe acute respiratory syndrome coronavirus 2 in the older aged population
The detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) is the standard method for the diagnosis of coronavirus disease 2019 (COVID-19). This PCR test can be positive even in patients who ha...
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| Veröffentlicht in: | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2021-07, Vol.27 (7), p.1119-1121 |
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| container_title | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy |
| container_volume | 27 |
| creator | Ueno, Akitoshi Kawasuji, Hitoshi Miyajima, Yuki Fukui, Yasutaka Sakamaki, Ippei Saito, Mayuko Yamashiro, Seiji Morinaga, Yoshitomo Oishi, Kazunori Yamamoto, Yoshihiro |
| description | The detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) is the standard method for the diagnosis of coronavirus disease 2019 (COVID-19). This PCR test can be positive even in patients who have recovered from the disease, and the duration for achieving viral clearance has not been clarified yet.
This study was conducted between April 3, 2020, and June 17, 2020, at the Toyama University Hospital and the Toyama Rehabilitation Home. We collected the data of patients with COVID-19, analyzing the duration until twice-consecutive negative qRT-PCR test.
A total of 42 patients were enrolled. The median duration of the twice-consecutive negative qRT-PCR test was 29.0 d (interquartile range: 25.75–35.25). The longest duration of viral shedding was 73 d. The duration of viral clearance was significantly longer in the older (>65 years) group than in the younger group (34.5 d vs. 25.0 d, P |
| doi_str_mv | 10.1016/j.jiac.2021.03.007 |
| format | Article |
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This study was conducted between April 3, 2020, and June 17, 2020, at the Toyama University Hospital and the Toyama Rehabilitation Home. We collected the data of patients with COVID-19, analyzing the duration until twice-consecutive negative qRT-PCR test.
A total of 42 patients were enrolled. The median duration of the twice-consecutive negative qRT-PCR test was 29.0 d (interquartile range: 25.75–35.25). The longest duration of viral shedding was 73 d. The duration of viral clearance was significantly longer in the older (>65 years) group than in the younger group (34.5 d vs. 25.0 d, P < 0.0001).
This study demonstrated that viral clearance tends to be sustained in the older adults.</description><identifier>ISSN: 1341-321X</identifier><identifier>EISSN: 1437-7780</identifier><identifier>DOI: 10.1016/j.jiac.2021.03.007</identifier><identifier>PMID: 33781692</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Aged ; COVID-19 ; Humans ; Middle Aged ; qRT-PCR ; Real-Time Polymerase Chain Reaction ; Retrospective Studies ; RNA, Viral - genetics ; SARS-CoV-2 ; Viral clearance ; Virus Shedding</subject><ispartof>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2021-07, Vol.27 (7), p.1119-1121</ispartof><rights>2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases</rights><rights>Copyright © 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.</rights><rights>2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-6b03ed1055b6b949636991b2f2f2acf4b1b67a15fbf0303d3dc45d3621da5d663</citedby><cites>FETCH-LOGICAL-c479t-6b03ed1055b6b949636991b2f2f2acf4b1b67a15fbf0303d3dc45d3621da5d663</cites><orcidid>0000-0003-2088-8724</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33781692$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ueno, Akitoshi</creatorcontrib><creatorcontrib>Kawasuji, Hitoshi</creatorcontrib><creatorcontrib>Miyajima, Yuki</creatorcontrib><creatorcontrib>Fukui, Yasutaka</creatorcontrib><creatorcontrib>Sakamaki, Ippei</creatorcontrib><creatorcontrib>Saito, Mayuko</creatorcontrib><creatorcontrib>Yamashiro, Seiji</creatorcontrib><creatorcontrib>Morinaga, Yoshitomo</creatorcontrib><creatorcontrib>Oishi, Kazunori</creatorcontrib><creatorcontrib>Yamamoto, Yoshihiro</creatorcontrib><title>Prolonged viral clearance of severe acute respiratory syndrome coronavirus 2 in the older aged population</title><title>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</title><addtitle>J Infect Chemother</addtitle><description>The detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) is the standard method for the diagnosis of coronavirus disease 2019 (COVID-19). This PCR test can be positive even in patients who have recovered from the disease, and the duration for achieving viral clearance has not been clarified yet.
This study was conducted between April 3, 2020, and June 17, 2020, at the Toyama University Hospital and the Toyama Rehabilitation Home. We collected the data of patients with COVID-19, analyzing the duration until twice-consecutive negative qRT-PCR test.
A total of 42 patients were enrolled. The median duration of the twice-consecutive negative qRT-PCR test was 29.0 d (interquartile range: 25.75–35.25). The longest duration of viral shedding was 73 d. The duration of viral clearance was significantly longer in the older (>65 years) group than in the younger group (34.5 d vs. 25.0 d, P < 0.0001).
This study demonstrated that viral clearance tends to be sustained in the older adults.</description><subject>Aged</subject><subject>COVID-19</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>qRT-PCR</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Retrospective Studies</subject><subject>RNA, Viral - genetics</subject><subject>SARS-CoV-2</subject><subject>Viral clearance</subject><subject>Virus Shedding</subject><issn>1341-321X</issn><issn>1437-7780</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctq3DAYRkVpaNKkL9BF0bIbu7pYkg2hUEKTFgLJIoHshCz9TjR4JEeyB-btKzNpaDdBCwn0fUeXg9BnSmpKqPy2qTfe2JoRRmvCa0LUO3RCG64qpVryvqx5QyvO6MMx-pjzhhCqRNt-QMecq5bKjp0gf5viGMMjOLzzyYzYjmCSCRZwHHCGHSTAxi4z4AR5KpE5pj3O--BS3AK2McVgSnXJmGEf8PxUmqODhM0KneK0jGb2MZyho8GMGT69zKfo_vLn3cWv6vrm6vfFj-vKNqqbK9kTDo4SIXrZd00nuew62rOhDGOHpqe9VIaKoR8IJ9xxZxvhuGTUGeGk5Kfo-4E7Lf0WnIUwl3fpKfmtSXsdjdf_7wT_pB_jTqtO0LZlBfD1BZDi8wJ51lufLYyjCRCXrJkgijaSizXKDlGbYs4JhtdjKNGrI73RqyO9OtKE6-KolL78e8HXyl8pJXB-CED5pp2HpLP1UJQ4n8DO2kX_Fv8PWHKlwA</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Ueno, Akitoshi</creator><creator>Kawasuji, Hitoshi</creator><creator>Miyajima, Yuki</creator><creator>Fukui, Yasutaka</creator><creator>Sakamaki, Ippei</creator><creator>Saito, Mayuko</creator><creator>Yamashiro, Seiji</creator><creator>Morinaga, Yoshitomo</creator><creator>Oishi, Kazunori</creator><creator>Yamamoto, Yoshihiro</creator><general>Elsevier Ltd</general><general>Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. 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This PCR test can be positive even in patients who have recovered from the disease, and the duration for achieving viral clearance has not been clarified yet.
This study was conducted between April 3, 2020, and June 17, 2020, at the Toyama University Hospital and the Toyama Rehabilitation Home. We collected the data of patients with COVID-19, analyzing the duration until twice-consecutive negative qRT-PCR test.
A total of 42 patients were enrolled. The median duration of the twice-consecutive negative qRT-PCR test was 29.0 d (interquartile range: 25.75–35.25). The longest duration of viral shedding was 73 d. The duration of viral clearance was significantly longer in the older (>65 years) group than in the younger group (34.5 d vs. 25.0 d, P < 0.0001).
This study demonstrated that viral clearance tends to be sustained in the older adults.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>33781692</pmid><doi>10.1016/j.jiac.2021.03.007</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0003-2088-8724</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged COVID-19 Humans Middle Aged qRT-PCR Real-Time Polymerase Chain Reaction Retrospective Studies RNA, Viral - genetics SARS-CoV-2 Viral clearance Virus Shedding |
| title | Prolonged viral clearance of severe acute respiratory syndrome coronavirus 2 in the older aged population |
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