A pre-clinical functional assessment of an acellular scaffold intended for the treatment of hard-to-heal wounds

The majority of the population experience successful wound‐healing outcomes; however, 1–3% of those aged over 65 years experience delayed wound healing and wound perpetuation. These hard‐to‐heal wounds contain degraded and dysfunctional extracellular matrix (ECM); yet, the integrity of this structur...

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Veröffentlicht in:	International wound journal 2015-04, Vol.12 (2), p.160-168
Hauptverfasser:	Shooter, Gary K, Van Lonkhuyzen, Derek R, Croll, Tristan I, Cao, Yang, Xie, Yan, Broadbent, James A, Stupar, Dario, Lynam, Emily C, Upton, Zee
Format:	Artikel
Sprache:	eng
Schlagworte:	Acellular scaffold Animals Cell Culture Techniques Dermis - metabolism Disease Models, Animal Extracellular matrix Female Fibroblasts - drug effects Hard-to-heal wounds Humans Keratinocytes - drug effects Original Swine Tissue Scaffolds Vitronectin - pharmacokinetics Vitronectin - therapeutic use Wound Healing Wounds, Penetrating - therapy
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