Improvement of wound tissue repair by chitosan films containing (-)-borneol, a bicyclic monoterpene alcohol, in rats
The aim of this study was to investigate the wound‐healing activity of (–)‐borneol (BOR) incorporated in chitosan film on healing protocol in rodents. To assess the BOR wound‐healing potential, male Wistar rats were subjected to a full‐thickness excisional wound. The animals were divided into three...
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| Veröffentlicht in: | International wound journal 2016-10, Vol.13 (5), p.799-808 |
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| creator | Barreto, Rosana SS Quintans, Jullyana SS Barreto, André S Albuquerque-Júnior, Ricardo LC Galvão, Juliana G Gonsalves, Joice KMC Nunes, Rogéria S Camargo, Enilton A Lucca-Júnior, Waldecy Soares, Rosilene C Feitosa, Vera Lúcia C Quintans-Júnior, Lucindo J |
| description | The aim of this study was to investigate the wound‐healing activity of (–)‐borneol (BOR) incorporated in chitosan film on healing protocol in rodents. To assess the BOR wound‐healing potential, male Wistar rats were subjected to a full‐thickness excisional wound. The animals were divided into three groups: dressed with chitosan‐based film (QUIN); dressed with chitosan‐based film containing 0·5% BOR (QUIBO05); or dressed with chitosan‐based film containing 1% BOR (QUIBO1). Dressing the wound areas and histological analysis were performed on the 3rd, 7th, 14th, and 21st days. The myeloperoxidase (MPO) activity was assessed on the third and seventh days after surgical procedures. Wounds dressed with chitosan‐based film containing BOR reduced significantly the MPO activity (P < 0·001), showed significantly larger wound retraction rates (7 days, P < 0·05), improved the granulation reaction, and also provided better collagenisation density and arrangement during wound healing. It is suggested that BOR modulates the wound‐healing process and is a promising compound to be used in wound care. This product may be quite useful in improving wound healing and could be a new biotechnological product with healing properties and clinical application. Further ongoing studies will enable us to understand the precise mechanisms whereby BOR improves the wound‐healing process. |
| doi_str_mv | 10.1111/iwj.12385 |
| format | Article |
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To assess the BOR wound‐healing potential, male Wistar rats were subjected to a full‐thickness excisional wound. The animals were divided into three groups: dressed with chitosan‐based film (QUIN); dressed with chitosan‐based film containing 0·5% BOR (QUIBO05); or dressed with chitosan‐based film containing 1% BOR (QUIBO1). Dressing the wound areas and histological analysis were performed on the 3rd, 7th, 14th, and 21st days. The myeloperoxidase (MPO) activity was assessed on the third and seventh days after surgical procedures. Wounds dressed with chitosan‐based film containing BOR reduced significantly the MPO activity (P < 0·001), showed significantly larger wound retraction rates (7 days, P < 0·05), improved the granulation reaction, and also provided better collagenisation density and arrangement during wound healing. It is suggested that BOR modulates the wound‐healing process and is a promising compound to be used in wound care. This product may be quite useful in improving wound healing and could be a new biotechnological product with healing properties and clinical application. Further ongoing studies will enable us to understand the precise mechanisms whereby BOR improves the wound‐healing process.</description><identifier>ISSN: 1742-4801</identifier><identifier>EISSN: 1742-481X</identifier><identifier>DOI: 10.1111/iwj.12385</identifier><identifier>PMID: 25471005</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Bandages ; Bornanes - therapeutic use ; Borneol ; Chitosan ; Chitosan - therapeutic use ; Male ; Monoterpene ; Monoterpenes - therapeutic use ; Original ; Rats ; Rats, Wistar ; Skin - drug effects ; Skin - pathology ; Wound healing ; Wound Healing - drug effects ; Wound Healing - physiology ; Wounds and Injuries - drug therapy</subject><ispartof>International wound journal, 2016-10, Vol.13 (5), p.799-808</ispartof><rights>2014 Medicalhelplines.com Inc and John Wiley & Sons Ltd</rights><rights>2014 Medicalhelplines.com Inc and John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4535-46162ff94c296910eadbc4c5437c5b1ffd77f1f4c11f7be406f10a6ea8b85b7f3</citedby><cites>FETCH-LOGICAL-c4535-46162ff94c296910eadbc4c5437c5b1ffd77f1f4c11f7be406f10a6ea8b85b7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949920/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949920/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fiwj.12385$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25471005$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barreto, Rosana SS</creatorcontrib><creatorcontrib>Quintans, Jullyana SS</creatorcontrib><creatorcontrib>Barreto, André S</creatorcontrib><creatorcontrib>Albuquerque-Júnior, Ricardo LC</creatorcontrib><creatorcontrib>Galvão, Juliana G</creatorcontrib><creatorcontrib>Gonsalves, Joice KMC</creatorcontrib><creatorcontrib>Nunes, Rogéria S</creatorcontrib><creatorcontrib>Camargo, Enilton A</creatorcontrib><creatorcontrib>Lucca-Júnior, Waldecy</creatorcontrib><creatorcontrib>Soares, Rosilene C</creatorcontrib><creatorcontrib>Feitosa, Vera Lúcia C</creatorcontrib><creatorcontrib>Quintans-Júnior, Lucindo J</creatorcontrib><title>Improvement of wound tissue repair by chitosan films containing (-)-borneol, a bicyclic monoterpene alcohol, in rats</title><title>International wound journal</title><addtitle>Int Wound J</addtitle><description>The aim of this study was to investigate the wound‐healing activity of (–)‐borneol (BOR) incorporated in chitosan film on healing protocol in rodents. To assess the BOR wound‐healing potential, male Wistar rats were subjected to a full‐thickness excisional wound. The animals were divided into three groups: dressed with chitosan‐based film (QUIN); dressed with chitosan‐based film containing 0·5% BOR (QUIBO05); or dressed with chitosan‐based film containing 1% BOR (QUIBO1). Dressing the wound areas and histological analysis were performed on the 3rd, 7th, 14th, and 21st days. The myeloperoxidase (MPO) activity was assessed on the third and seventh days after surgical procedures. Wounds dressed with chitosan‐based film containing BOR reduced significantly the MPO activity (P < 0·001), showed significantly larger wound retraction rates (7 days, P < 0·05), improved the granulation reaction, and also provided better collagenisation density and arrangement during wound healing. It is suggested that BOR modulates the wound‐healing process and is a promising compound to be used in wound care. This product may be quite useful in improving wound healing and could be a new biotechnological product with healing properties and clinical application. Further ongoing studies will enable us to understand the precise mechanisms whereby BOR improves the wound‐healing process.</description><subject>Animals</subject><subject>Bandages</subject><subject>Bornanes - therapeutic use</subject><subject>Borneol</subject><subject>Chitosan</subject><subject>Chitosan - therapeutic use</subject><subject>Male</subject><subject>Monoterpene</subject><subject>Monoterpenes - therapeutic use</subject><subject>Original</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Skin - drug effects</subject><subject>Skin - pathology</subject><subject>Wound healing</subject><subject>Wound Healing - drug effects</subject><subject>Wound Healing - physiology</subject><subject>Wounds and Injuries - drug therapy</subject><issn>1742-4801</issn><issn>1742-481X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFvFCEYhonR2Fo9-AcMxzZxWpiBYbiYmEbrmlUTU1NvBFjoUhkYgem6_17qths9yAWS7_ke-HgBeInRKa7rzG1uTnHbDfQROMSMtA0Z8PfH-zPCB-BZzjcItZxS9hQctJQwjBA9BGUxTinemtGEAqOFmziHFSwu59nAZCbpElRbqNeuxCwDtM6PGeoYinTBhWt43Jw0KqZgon8NJVROb7V3Go4xxGLSZIKB0uu4vqu7AJMs-Tl4YqXP5sX9fgS-vX93ef6hWX65WJy_XTaa0I42pMd9ay0nuuU9x8jIldJEU9IxTRW2dsWYxZZojC1ThqDeYiR7Iwc1UMVsdwTe7LzTrEaz0nXGJL2Ykhtl2ooonfi3EtxaXMdbwTjhvEVVcHwvSPHnbHIRo8vaeC_rvHMWeMCc12_thoqe7FCdYs7J2P01GIm7lERNSfxJqbKv_n7XnnyIpQJnO2DjvNn-3yQWVx8flM2uw-Vifu07ZPohetYxKq4-Xwj6iX9l7RKJy-4342ut5g</recordid><startdate>201610</startdate><enddate>201610</enddate><creator>Barreto, Rosana SS</creator><creator>Quintans, Jullyana SS</creator><creator>Barreto, André S</creator><creator>Albuquerque-Júnior, Ricardo LC</creator><creator>Galvão, Juliana G</creator><creator>Gonsalves, Joice KMC</creator><creator>Nunes, Rogéria S</creator><creator>Camargo, Enilton A</creator><creator>Lucca-Júnior, Waldecy</creator><creator>Soares, Rosilene C</creator><creator>Feitosa, Vera Lúcia C</creator><creator>Quintans-Júnior, Lucindo J</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201610</creationdate><title>Improvement of wound tissue repair by chitosan films containing (-)-borneol, a bicyclic monoterpene alcohol, in rats</title><author>Barreto, Rosana SS ; Quintans, Jullyana SS ; Barreto, André S ; Albuquerque-Júnior, Ricardo LC ; Galvão, Juliana G ; Gonsalves, Joice KMC ; Nunes, Rogéria S ; Camargo, Enilton A ; Lucca-Júnior, Waldecy ; Soares, Rosilene C ; Feitosa, Vera Lúcia C ; Quintans-Júnior, Lucindo J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4535-46162ff94c296910eadbc4c5437c5b1ffd77f1f4c11f7be406f10a6ea8b85b7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Bandages</topic><topic>Bornanes - therapeutic use</topic><topic>Borneol</topic><topic>Chitosan</topic><topic>Chitosan - therapeutic use</topic><topic>Male</topic><topic>Monoterpene</topic><topic>Monoterpenes - therapeutic use</topic><topic>Original</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Skin - drug effects</topic><topic>Skin - pathology</topic><topic>Wound healing</topic><topic>Wound Healing - drug effects</topic><topic>Wound Healing - physiology</topic><topic>Wounds and Injuries - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barreto, Rosana SS</creatorcontrib><creatorcontrib>Quintans, Jullyana SS</creatorcontrib><creatorcontrib>Barreto, André S</creatorcontrib><creatorcontrib>Albuquerque-Júnior, Ricardo LC</creatorcontrib><creatorcontrib>Galvão, Juliana G</creatorcontrib><creatorcontrib>Gonsalves, Joice KMC</creatorcontrib><creatorcontrib>Nunes, Rogéria S</creatorcontrib><creatorcontrib>Camargo, Enilton A</creatorcontrib><creatorcontrib>Lucca-Júnior, Waldecy</creatorcontrib><creatorcontrib>Soares, Rosilene C</creatorcontrib><creatorcontrib>Feitosa, Vera Lúcia C</creatorcontrib><creatorcontrib>Quintans-Júnior, Lucindo J</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International wound journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Barreto, Rosana SS</au><au>Quintans, Jullyana SS</au><au>Barreto, André S</au><au>Albuquerque-Júnior, Ricardo LC</au><au>Galvão, Juliana G</au><au>Gonsalves, Joice KMC</au><au>Nunes, Rogéria S</au><au>Camargo, Enilton A</au><au>Lucca-Júnior, Waldecy</au><au>Soares, Rosilene C</au><au>Feitosa, Vera Lúcia C</au><au>Quintans-Júnior, Lucindo J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improvement of wound tissue repair by chitosan films containing (-)-borneol, a bicyclic monoterpene alcohol, in rats</atitle><jtitle>International wound journal</jtitle><addtitle>Int Wound J</addtitle><date>2016-10</date><risdate>2016</risdate><volume>13</volume><issue>5</issue><spage>799</spage><epage>808</epage><pages>799-808</pages><issn>1742-4801</issn><eissn>1742-481X</eissn><abstract>The aim of this study was to investigate the wound‐healing activity of (–)‐borneol (BOR) incorporated in chitosan film on healing protocol in rodents. To assess the BOR wound‐healing potential, male Wistar rats were subjected to a full‐thickness excisional wound. The animals were divided into three groups: dressed with chitosan‐based film (QUIN); dressed with chitosan‐based film containing 0·5% BOR (QUIBO05); or dressed with chitosan‐based film containing 1% BOR (QUIBO1). Dressing the wound areas and histological analysis were performed on the 3rd, 7th, 14th, and 21st days. The myeloperoxidase (MPO) activity was assessed on the third and seventh days after surgical procedures. Wounds dressed with chitosan‐based film containing BOR reduced significantly the MPO activity (P < 0·001), showed significantly larger wound retraction rates (7 days, P < 0·05), improved the granulation reaction, and also provided better collagenisation density and arrangement during wound healing. It is suggested that BOR modulates the wound‐healing process and is a promising compound to be used in wound care. This product may be quite useful in improving wound healing and could be a new biotechnological product with healing properties and clinical application. Further ongoing studies will enable us to understand the precise mechanisms whereby BOR improves the wound‐healing process.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>25471005</pmid><doi>10.1111/iwj.12385</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International wound journal, 2016-10, Vol.13 (5), p.799-808 |
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| language | eng |
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| source | Wiley Online Library Open Access |
| subjects | Animals Bandages Bornanes - therapeutic use Borneol Chitosan Chitosan - therapeutic use Male Monoterpene Monoterpenes - therapeutic use Original Rats Rats, Wistar Skin - drug effects Skin - pathology Wound healing Wound Healing - drug effects Wound Healing - physiology Wounds and Injuries - drug therapy |
| title | Improvement of wound tissue repair by chitosan films containing (-)-borneol, a bicyclic monoterpene alcohol, in rats |
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