Maturation, inactivation, and recovery mechanisms of soluble guanylyl cyclase

Soluble guanylate cyclase (sGC) is a heme-containing heterodimeric enzyme that generates many molecules of cGMP in response to its ligand nitric oxide (NO); sGC thereby acts as an amplifier in NO-driven biological signaling cascades. Because sGC helps regulate the cardiovascular, neuronal, and gastr...

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Veröffentlicht in:	The Journal of biological chemistry 2021-01, Vol.296, p.100336-100336, Article 100336
Hauptverfasser:	Stuehr, Dennis J., Misra, Saurav, Dai, Yue, Ghosh, Arnab
Format:	Artikel
Sprache:	eng
Schlagworte:	cell signaling cytochrome b5 reductase Hsp90 hypertension JBC Reviews nitric oxide protein nitrosation protein oxidation
Online-Zugang:	Volltext
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