The short third intracellular loop and cytoplasmic tail of bitter taste receptors provide functionally relevant GRK phosphorylation sites in TAS2R14

For most G protein–coupled receptors, the third intracellular loop (IL3) and carboxy-terminal tail (CT) are sites for G protein–coupled receptor kinase (GRK)–mediated phosphorylation, leading to β-arrestin binding and agonist-specific desensitization. These regions of bitter taste receptors (TAS2Rs)...

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Veröffentlicht in:	The Journal of biological chemistry 2021-01, Vol.296, p.100216-100216, Article 100216
Hauptverfasser:	Kim, Donghwa, Castaño, Maria, Lujan, Lauren K., Woo, Jung A., Liggett, Stephen B.
Format:	Artikel
Sprache:	eng
Schlagworte:	desensitization G protein–coupled receptor kinases G protein–coupled receptors TAS2R β-arrestin
Online-Zugang:	Volltext
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