Using biochemistry and biophysics to extinguish androgen receptor signaling in prostate cancer

Castration resistant prostate cancer (CRPC) continues to be androgen receptor (AR) driven. Inhibition of AR signaling in CRPC could be advanced using state-of-the-art biophysical and biochemical techniques. Structural characterization of AR and its complexes by cryo-electron microscopy would advance...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2021-01, Vol.296, p.100240, Article 100240
Hauptverfasser:	Asangani, Irfan, Blair, Ian A., Van Duyne, Gregory, Hilser, Vincent J., Moiseenkova-Bell, Vera, Plymate, Stephen, Sprenger, Cynthia, Wand, A. Joshua, Penning, Trevor M.
Format:	Artikel
Sprache:	eng
Schlagworte:	aldo-keto reductase allostery androgen receptor Biochemical Phenomena Biophysical Phenomena cryo-electron microscopy Humans JBC Reviews Male mass spectrometry nuclear magnetic resonance Prostatic Neoplasms, Castration-Resistant - metabolism proteomics Receptors, Androgen - metabolism Signal Transduction splice variants
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!