PRAP1 is a novel lipid-binding protein that promotes lipid absorption by facilitating MTTP-mediated lipid transport

Microsomal triglyceride transfer protein (MTTP) is an endoplasmic reticulum resident protein that is essential for the assembly and secretion of triglyceride (TG)-rich, apoB-containing lipoproteins. Although the function and structure of mammalian MTTP have been extensively studied, how exactly MTTP...

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Veröffentlicht in:	The Journal of biological chemistry 2021-01, Vol.296, p.100052-100052, Article 100052
Hauptverfasser:	Peng, Hubert, Chiu, Tzu-Yuan, Liang, Yu-Jen, Lee, Chia-Jen, Liu, Chih-Syuan, Suen, Ching-Shu, Yen, Jeffrey J.-Y., Chen, Hung-Ta, Hwang, Ming-Jing, Hussain, M. Mahmood, Yang, Hsin-Chou, Yang-Yen, Hsin-Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apolipoprotein Apolipoprotein B-100 - genetics Apolipoprotein B-100 - metabolism Biological Transport Carrier Proteins - metabolism Diet, High-Fat Fatty Liver - genetics lipid absorption Lipid Metabolism lipid transport lipid-binding protein lipoprotein assembly and secretion Lipoproteins - metabolism Mice Mice, Knockout mouse MTTP PRAP1 Pregnancy Proteins - genetics Pregnancy Proteins - metabolism Protein Binding triglyceride Triglycerides - metabolism
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