Melatonin downregulates TRPC6, impairing store-operated calcium entry in triple-negative breast cancer cells

Melatonin has been reported to induce effective reduction in growth and development in a variety of tumors, including breast cancer. In triple-negative breast cancer (TNBC) cells, melatonin attenuates a variety of cancer features, such as tumor growth and apoptosis resistance, through a number of st...

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Veröffentlicht in:	The Journal of biological chemistry 2021-01, Vol.296, p.100254, Article 100254
Hauptverfasser:	Jardin, Isaac, Diez-Bello, Raquel, Falcon, Debora, Alvarado, Sandra, Regodon, Sergio, Salido, Gines M., Smani, Tarik, Rosado, Juan A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - pharmacology Calcium Channels - metabolism calcium entry Cell Line Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Down-Regulation - drug effects Humans melatonin Melatonin - pharmacology SOCE Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology triple-negative breast cancer cells TRPC6 TRPC6 Cation Channel - antagonists & inhibitors TRPC6 Cation Channel - metabolism
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