Concomitant Imbalances of Systemic and Mucosal Immunity Increase HIV Acquisition Risk

BACKGROUND:We previously reported association of increased cervical RANTES and decreased secretory leukocyte protease inhibitor (SLPI) with higher risk of HIV acquisition in reproductive-age women. We now examine the interaction of concomitantly altered systemic and cervical immunity on such risk. M...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1999) 2020-05, Vol.84 (1), p.85-91
Hauptverfasser:	Morrison, Charles S., Chen, Pai-Lien, Yamamoto, Hidemi, Gao, Xiaoming, Chipato, Tsungai, Anderson, Sharon, Barbieri, Robert, Salata, Robert, Doncel, Gustavo F., Fichorova, Raina N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult AIDS/HIV Biomarkers Biomarkers - blood Biomarkers - metabolism C-reactive protein Cell adhesion Cervix Cervix Uteri - immunology Cervix Uteri - metabolism Female Growth factors Health risks HIV HIV Infections - immunology Human immunodeficiency virus Humans IL-1β Immunity Immunity, Innate Immunity, Mucosal Infections Inflammation Innate immunity Intercellular adhesion molecule 1 Interleukin 1 receptor antagonist Interleukin 1 receptors Interleukin 6 Interleukin 7 Interleukin 8 Leukocytes Measurement methods Mucosal immunity Peripheral blood Prospective Studies Protease inhibitors Proteinase inhibitors RANTES Risk Risk Factors Uganda Vascular endothelial growth factor Young Adult Zimbabwe
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