Fc γ receptor IIIa/CD16a processing correlates with the expression of glycan-related genes in human natural killer cells

Many therapeutic monoclonal antibodies require binding to Fc γ receptors (FcγRs) for full effect and increasing the binding affinity increases efficacy. Preeminent among the five activating human FcγRs is FcγRIIIa/CD16a expressed by natural killer (NK) cells. CD16a is heavily processed, and recent r...

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Veröffentlicht in:	The Journal of biological chemistry 2021-01, Vol.296, p.100183-100183, Article 100183
Hauptverfasser:	Patel, Kashyap R., Rodriguez Benavente, Maria C., Lorenz, W. Walter, Mace, Emily M., Barb, Adam W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Fc-gamma receptor gene expression glycoproteomics N-linked glycosylation natural killer cells (NK cells) NK-92 YTS
Online-Zugang:	Volltext
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