Epoxide hydrolase 3 (Ephx3) gene disruption reduces ceramide linoleate epoxide hydrolysis and impairs skin barrier function

The mammalian epoxide hydrolase (EPHX)3 is known from in vitro experiments to efficiently hydrolyze the linoleate epoxides 9,10-epoxyoctadecamonoenoic acid (EpOME) and epoxyalcohol 9R,10R-trans-epoxy-11E-13R-hydroxy-octadecenoate to corresponding diols and triols, respectively. Herein we examined th...

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Veröffentlicht in:	The Journal of biological chemistry 2021-01, Vol.296, p.100198, Article 100198
Hauptverfasser:	Edin, Matthew L., Yamanashi, Haruto, Boeglin, William E., Graves, Joan P., DeGraff, Laura M., Lih, Fred B., Zeldin, Darryl C., Brash, Alan R.
Format:	Artikel
Sprache:	eng
Schlagworte:	12R-lipoxygenase EPHX1 EPHX2 EPHX3 epidermis epoxyalcohol ichthyosis LC-MS skin barrier function transepidermal water loss
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