MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease

Sickle cell disease (SCD) is associated with hemolysis, vascular inflammation, and organ damage. Affected patients experience chronic painful vaso-occlusive events requiring hospitalization. Hypoxia-induced polymerization of sickle hemoglobin S (HbS) contributes to sickling of red blood cells (RBCs)...

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Veröffentlicht in:	Blood advances 2021-03, Vol.5 (5), p.1388-1402
Hauptverfasser:	Demers, Melanie, Sturtevant, Sarah, Guertin, Kevin R., Gupta, Dipti, Desai, Kunal, Vieira, Benjamin F., Li, Wenjing, Hicks, Alexandra, Ismail, Ayman, Gonçalves, Bronner P., Di Caprio, Giuseppe, Schonbrun, Ethan, Hansen, Scott, Musayev, Faik N., Safo, Martin K., Wood, David K., Higgins, John M., Light, David R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Red Cells, Iron, and Erythropoiesis
Online-Zugang:	Volltext
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