Minor Changes in the Composition and Function of the Gut Microbiota During a 12-Week Whole Grain Wheat or Refined Wheat Intervention Correlate with Liver Fat in Overweight and Obese Adults
Whole grain wheat (WGW) products are advocated as a healthy choice when compared with refined wheat (RW). One proposed mechanism for these health benefits is via the microbiota, because WGW contains multiple fibers. WGW consumption has been proposed to ameliorate nonalcoholic fatty liver disease, in...
Gespeichert in:
| Veröffentlicht in: | The Journal of nutrition 2021-03, Vol.151 (3), p.491-502 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 502 |
|---|---|
| container_issue | 3 |
| container_start_page | 491 |
| container_title | The Journal of nutrition |
| container_volume | 151 |
| creator | van Trijp, Mara P H Schutte, Sophie Esser, Diederik Wopereis, Suzan Hoevenaars, Femke P M Hooiveld, Guido J E J Afman, Lydia A |
| description | Whole grain wheat (WGW) products are advocated as a healthy choice when compared with refined wheat (RW). One proposed mechanism for these health benefits is via the microbiota, because WGW contains multiple fibers. WGW consumption has been proposed to ameliorate nonalcoholic fatty liver disease, in which microbiota might play a role.
We investigated the effect of WGW compared with RW intervention on the fecal microbiota composition and functionality, and correlated intervention-induced changes in bacteria with changes in liver health parameters in adults with overweight or obesity.
We used data of a 12-wk double-blind, randomized, controlled, parallel trial to examine the effects of a WGW (98 g/d) or RW (98 g/d) intervention on the secondary outcomes fecal microbiota composition, predicted microbiota functionality, and stool consistency in 37 women and men (aged 45–70 y, BMI 25–35 kg/m2). The changes in microbiota composition, measured using 16S ribosomal RNA gene sequencing, after a 12-wk intervention were analyzed with nonparametric tests, and correlated with changes in liver fat and circulating concentrations of liver enzymes including alanine transaminase, aspartate transaminase, γ-glutamyltransferase, and serum amyloid A.
The WGW intervention increased the mean (± SD) relative abundances of Ruminococcaceae_UCG-014 (baseline: 2.2 ± 4.6%, differential change over time (Δ) 0.51 ± 4.2%), Ruminiclostridium_9 (baseline: 0.065 ± 0.11%, Δ 0.054 ± 0.14%), and Ruminococcaceae_NK4A214_group (baseline: 0.37 ± 0.56%, Δ 0.17 ± 0.83%), and also the predicted pathway acetyl-CoA fermentation to butyrate II (baseline: 0.23 ± 0.062%, Δ 0.035 ± 0.059%), compared with the RW intervention (P values |
| doi_str_mv | 10.1093/jn/nxaa312 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7948209</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/jn/nxaa312</oup_id><els_id>S0022316622000608</els_id><sourcerecordid>2509308210</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-b7810967d0cb0031785dbbc0a95559b8e99cf62a1a1c0f1e4ed8c272c2ed769d3</originalsourceid><addsrcrecordid>eNp9kl2LEzEUhoMobq3e-AMkIIII4yaZr8yNsFS7LnQpiNLLkEnOdFKnSU0y3d3_5o8ztnVREa_ycZ7z5s05B6HnlLylpMnPN_bc3kqZU_YATWhZ0KyihDxEE0IYy3JaVWfoSQgbQggtGv4YneU55byg9QR9vzbWeTzrpV1DwMbi2AOeue3OBRONs1hajeejVYeD6w7xyzHia6O8a42LEr8fvbFrLDFl2QrgK171bkiUl0lv1YOMOL3xCTpjQZ8urmwEvwd7kJ0572GQEfCNiT1emD14PE9Uyl-m_Q2YdR8PVpYtBMAXehxieIoedXII8Oy0TtGX-YfPs4_ZYnl5NbtYZKrgNGZtzVOdqloT1RKS05qXum0VkU1Zlk3LoWlUVzFJJVWko1CA5orVTDHQddXofIreHXV3Y7sFrZJrLwex82Yr_Z1w0og_I9b0Yu32om4KzlKLpuj1ScC7byOEKLYmKBgGacGNQbCiInWVN7xK6Mu_0I0bvU3fE6xMUoQzShL15kilHoTgobs3Q4n4ORRiY8VpKBL84nf79-ivKUjAqyPgxt3_hYojB6nYewNeBGXAKtDGg4pCO_OvtB_ZcdTk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2509308210</pqid></control><display><type>article</type><title>Minor Changes in the Composition and Function of the Gut Microbiota During a 12-Week Whole Grain Wheat or Refined Wheat Intervention Correlate with Liver Fat in Overweight and Obese Adults</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>van Trijp, Mara P H ; Schutte, Sophie ; Esser, Diederik ; Wopereis, Suzan ; Hoevenaars, Femke P M ; Hooiveld, Guido J E J ; Afman, Lydia A</creator><creatorcontrib>van Trijp, Mara P H ; Schutte, Sophie ; Esser, Diederik ; Wopereis, Suzan ; Hoevenaars, Femke P M ; Hooiveld, Guido J E J ; Afman, Lydia A</creatorcontrib><description>Whole grain wheat (WGW) products are advocated as a healthy choice when compared with refined wheat (RW). One proposed mechanism for these health benefits is via the microbiota, because WGW contains multiple fibers. WGW consumption has been proposed to ameliorate nonalcoholic fatty liver disease, in which microbiota might play a role.
We investigated the effect of WGW compared with RW intervention on the fecal microbiota composition and functionality, and correlated intervention-induced changes in bacteria with changes in liver health parameters in adults with overweight or obesity.
We used data of a 12-wk double-blind, randomized, controlled, parallel trial to examine the effects of a WGW (98 g/d) or RW (98 g/d) intervention on the secondary outcomes fecal microbiota composition, predicted microbiota functionality, and stool consistency in 37 women and men (aged 45–70 y, BMI 25–35 kg/m2). The changes in microbiota composition, measured using 16S ribosomal RNA gene sequencing, after a 12-wk intervention were analyzed with nonparametric tests, and correlated with changes in liver fat and circulating concentrations of liver enzymes including alanine transaminase, aspartate transaminase, γ-glutamyltransferase, and serum amyloid A.
The WGW intervention increased the mean (± SD) relative abundances of Ruminococcaceae_UCG-014 (baseline: 2.2 ± 4.6%, differential change over time (Δ) 0.51 ± 4.2%), Ruminiclostridium_9 (baseline: 0.065 ± 0.11%, Δ 0.054 ± 0.14%), and Ruminococcaceae_NK4A214_group (baseline: 0.37 ± 0.56%, Δ 0.17 ± 0.83%), and also the predicted pathway acetyl-CoA fermentation to butyrate II (baseline: 0.23 ± 0.062%, Δ 0.035 ± 0.059%), compared with the RW intervention (P values <0.05). A change in Ruminococcaceae_NK4A214_group was positively correlated with the change in liver fat, in both the WGW (ρ = 0.54; P = 0.026) and RW (ρ = 0.67; P = 0.024) groups.
In middle-aged overweight and obese adults, a 12-wk WGW intervention increased the relative abundance of a number of bacterial taxa from the family Ruminococcaceae and increased predicted fermentation pathways when compared with an RW intervention. Potential protective health effects of replacement of RW by WGW on metabolic organs, such as the liver, via modulation of the microbiota, deserve further investigation.
This trial was registered at clinicaltrials.gov as NCT02385149.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/nxaa312</identifier><identifier>PMID: 33188417</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Abundance ; Adults ; Aged ; Alanine ; Alanine transaminase ; Amyloid ; Aspartate transaminase ; Biochemical, Molecular, and Genetic Mechanisms ; Biomarkers ; Body weight ; Composition ; Correlation analysis ; Dietary Fiber - administration & dosage ; Double-Blind Method ; Fatty liver ; Fatty Liver - microbiology ; Fecal microflora ; Feces ; Feces - microbiology ; Female ; Fermentation ; Fibers ; Flour ; Gastrointestinal Microbiome ; Gene sequencing ; gut microbiota ; human ; Humans ; Intervention ; Intestinal microflora ; Liver ; Liver - metabolism ; Liver - microbiology ; Liver diseases ; Male ; Men ; Metabolic Networks and Pathways ; Microbiota ; Middle Aged ; Obesity ; Organs ; Overweight ; Overweight - metabolism ; Overweight - microbiology ; overweight/obesity ; refined wheat ; Relative abundance ; rRNA 16S ; Ruminococcaceae ; Transaminase ; Wheat ; whole grain wheat ; Whole Grains ; γ-Glutamyltransferase</subject><ispartof>The Journal of nutrition, 2021-03, Vol.151 (3), p.491-502</ispartof><rights>2021 American Society for Nutrition.</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the American Society for Nutrition. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the American Society for Nutrition.</rights><rights>Copyright American Institute of Nutrition Mar 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-b7810967d0cb0031785dbbc0a95559b8e99cf62a1a1c0f1e4ed8c272c2ed769d3</citedby><cites>FETCH-LOGICAL-c481t-b7810967d0cb0031785dbbc0a95559b8e99cf62a1a1c0f1e4ed8c272c2ed769d3</cites><orcidid>0000-0001-9612-657X ; 0000-0003-1954-3542 ; 0000-0002-7939-6217</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33188417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Trijp, Mara P H</creatorcontrib><creatorcontrib>Schutte, Sophie</creatorcontrib><creatorcontrib>Esser, Diederik</creatorcontrib><creatorcontrib>Wopereis, Suzan</creatorcontrib><creatorcontrib>Hoevenaars, Femke P M</creatorcontrib><creatorcontrib>Hooiveld, Guido J E J</creatorcontrib><creatorcontrib>Afman, Lydia A</creatorcontrib><title>Minor Changes in the Composition and Function of the Gut Microbiota During a 12-Week Whole Grain Wheat or Refined Wheat Intervention Correlate with Liver Fat in Overweight and Obese Adults</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Whole grain wheat (WGW) products are advocated as a healthy choice when compared with refined wheat (RW). One proposed mechanism for these health benefits is via the microbiota, because WGW contains multiple fibers. WGW consumption has been proposed to ameliorate nonalcoholic fatty liver disease, in which microbiota might play a role.
We investigated the effect of WGW compared with RW intervention on the fecal microbiota composition and functionality, and correlated intervention-induced changes in bacteria with changes in liver health parameters in adults with overweight or obesity.
We used data of a 12-wk double-blind, randomized, controlled, parallel trial to examine the effects of a WGW (98 g/d) or RW (98 g/d) intervention on the secondary outcomes fecal microbiota composition, predicted microbiota functionality, and stool consistency in 37 women and men (aged 45–70 y, BMI 25–35 kg/m2). The changes in microbiota composition, measured using 16S ribosomal RNA gene sequencing, after a 12-wk intervention were analyzed with nonparametric tests, and correlated with changes in liver fat and circulating concentrations of liver enzymes including alanine transaminase, aspartate transaminase, γ-glutamyltransferase, and serum amyloid A.
The WGW intervention increased the mean (± SD) relative abundances of Ruminococcaceae_UCG-014 (baseline: 2.2 ± 4.6%, differential change over time (Δ) 0.51 ± 4.2%), Ruminiclostridium_9 (baseline: 0.065 ± 0.11%, Δ 0.054 ± 0.14%), and Ruminococcaceae_NK4A214_group (baseline: 0.37 ± 0.56%, Δ 0.17 ± 0.83%), and also the predicted pathway acetyl-CoA fermentation to butyrate II (baseline: 0.23 ± 0.062%, Δ 0.035 ± 0.059%), compared with the RW intervention (P values <0.05). A change in Ruminococcaceae_NK4A214_group was positively correlated with the change in liver fat, in both the WGW (ρ = 0.54; P = 0.026) and RW (ρ = 0.67; P = 0.024) groups.
In middle-aged overweight and obese adults, a 12-wk WGW intervention increased the relative abundance of a number of bacterial taxa from the family Ruminococcaceae and increased predicted fermentation pathways when compared with an RW intervention. Potential protective health effects of replacement of RW by WGW on metabolic organs, such as the liver, via modulation of the microbiota, deserve further investigation.
This trial was registered at clinicaltrials.gov as NCT02385149.</description><subject>Abundance</subject><subject>Adults</subject><subject>Aged</subject><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Amyloid</subject><subject>Aspartate transaminase</subject><subject>Biochemical, Molecular, and Genetic Mechanisms</subject><subject>Biomarkers</subject><subject>Body weight</subject><subject>Composition</subject><subject>Correlation analysis</subject><subject>Dietary Fiber - administration & dosage</subject><subject>Double-Blind Method</subject><subject>Fatty liver</subject><subject>Fatty Liver - microbiology</subject><subject>Fecal microflora</subject><subject>Feces</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Fermentation</subject><subject>Fibers</subject><subject>Flour</subject><subject>Gastrointestinal Microbiome</subject><subject>Gene sequencing</subject><subject>gut microbiota</subject><subject>human</subject><subject>Humans</subject><subject>Intervention</subject><subject>Intestinal microflora</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Liver - microbiology</subject><subject>Liver diseases</subject><subject>Male</subject><subject>Men</subject><subject>Metabolic Networks and Pathways</subject><subject>Microbiota</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Organs</subject><subject>Overweight</subject><subject>Overweight - metabolism</subject><subject>Overweight - microbiology</subject><subject>overweight/obesity</subject><subject>refined wheat</subject><subject>Relative abundance</subject><subject>rRNA 16S</subject><subject>Ruminococcaceae</subject><subject>Transaminase</subject><subject>Wheat</subject><subject>whole grain wheat</subject><subject>Whole Grains</subject><subject>γ-Glutamyltransferase</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><recordid>eNp9kl2LEzEUhoMobq3e-AMkIIII4yaZr8yNsFS7LnQpiNLLkEnOdFKnSU0y3d3_5o8ztnVREa_ycZ7z5s05B6HnlLylpMnPN_bc3kqZU_YATWhZ0KyihDxEE0IYy3JaVWfoSQgbQggtGv4YneU55byg9QR9vzbWeTzrpV1DwMbi2AOeue3OBRONs1hajeejVYeD6w7xyzHia6O8a42LEr8fvbFrLDFl2QrgK171bkiUl0lv1YOMOL3xCTpjQZ8urmwEvwd7kJ0572GQEfCNiT1emD14PE9Uyl-m_Q2YdR8PVpYtBMAXehxieIoedXII8Oy0TtGX-YfPs4_ZYnl5NbtYZKrgNGZtzVOdqloT1RKS05qXum0VkU1Zlk3LoWlUVzFJJVWko1CA5orVTDHQddXofIreHXV3Y7sFrZJrLwex82Yr_Z1w0og_I9b0Yu32om4KzlKLpuj1ScC7byOEKLYmKBgGacGNQbCiInWVN7xK6Mu_0I0bvU3fE6xMUoQzShL15kilHoTgobs3Q4n4ORRiY8VpKBL84nf79-ivKUjAqyPgxt3_hYojB6nYewNeBGXAKtDGg4pCO_OvtB_ZcdTk</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>van Trijp, Mara P H</creator><creator>Schutte, Sophie</creator><creator>Esser, Diederik</creator><creator>Wopereis, Suzan</creator><creator>Hoevenaars, Femke P M</creator><creator>Hooiveld, Guido J E J</creator><creator>Afman, Lydia A</creator><general>Elsevier Inc</general><general>Oxford University Press</general><general>American Institute of Nutrition</general><scope>6I.</scope><scope>AAFTH</scope><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9612-657X</orcidid><orcidid>https://orcid.org/0000-0003-1954-3542</orcidid><orcidid>https://orcid.org/0000-0002-7939-6217</orcidid></search><sort><creationdate>20210301</creationdate><title>Minor Changes in the Composition and Function of the Gut Microbiota During a 12-Week Whole Grain Wheat or Refined Wheat Intervention Correlate with Liver Fat in Overweight and Obese Adults</title><author>van Trijp, Mara P H ; Schutte, Sophie ; Esser, Diederik ; Wopereis, Suzan ; Hoevenaars, Femke P M ; Hooiveld, Guido J E J ; Afman, Lydia A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-b7810967d0cb0031785dbbc0a95559b8e99cf62a1a1c0f1e4ed8c272c2ed769d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abundance</topic><topic>Adults</topic><topic>Aged</topic><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Amyloid</topic><topic>Aspartate transaminase</topic><topic>Biochemical, Molecular, and Genetic Mechanisms</topic><topic>Biomarkers</topic><topic>Body weight</topic><topic>Composition</topic><topic>Correlation analysis</topic><topic>Dietary Fiber - administration & dosage</topic><topic>Double-Blind Method</topic><topic>Fatty liver</topic><topic>Fatty Liver - microbiology</topic><topic>Fecal microflora</topic><topic>Feces</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Fermentation</topic><topic>Fibers</topic><topic>Flour</topic><topic>Gastrointestinal Microbiome</topic><topic>Gene sequencing</topic><topic>gut microbiota</topic><topic>human</topic><topic>Humans</topic><topic>Intervention</topic><topic>Intestinal microflora</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Liver - microbiology</topic><topic>Liver diseases</topic><topic>Male</topic><topic>Men</topic><topic>Metabolic Networks and Pathways</topic><topic>Microbiota</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Organs</topic><topic>Overweight</topic><topic>Overweight - metabolism</topic><topic>Overweight - microbiology</topic><topic>overweight/obesity</topic><topic>refined wheat</topic><topic>Relative abundance</topic><topic>rRNA 16S</topic><topic>Ruminococcaceae</topic><topic>Transaminase</topic><topic>Wheat</topic><topic>whole grain wheat</topic><topic>Whole Grains</topic><topic>γ-Glutamyltransferase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Trijp, Mara P H</creatorcontrib><creatorcontrib>Schutte, Sophie</creatorcontrib><creatorcontrib>Esser, Diederik</creatorcontrib><creatorcontrib>Wopereis, Suzan</creatorcontrib><creatorcontrib>Hoevenaars, Femke P M</creatorcontrib><creatorcontrib>Hooiveld, Guido J E J</creatorcontrib><creatorcontrib>Afman, Lydia A</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Oxford Journals Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Trijp, Mara P H</au><au>Schutte, Sophie</au><au>Esser, Diederik</au><au>Wopereis, Suzan</au><au>Hoevenaars, Femke P M</au><au>Hooiveld, Guido J E J</au><au>Afman, Lydia A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Minor Changes in the Composition and Function of the Gut Microbiota During a 12-Week Whole Grain Wheat or Refined Wheat Intervention Correlate with Liver Fat in Overweight and Obese Adults</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>151</volume><issue>3</issue><spage>491</spage><epage>502</epage><pages>491-502</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><abstract>Whole grain wheat (WGW) products are advocated as a healthy choice when compared with refined wheat (RW). One proposed mechanism for these health benefits is via the microbiota, because WGW contains multiple fibers. WGW consumption has been proposed to ameliorate nonalcoholic fatty liver disease, in which microbiota might play a role.
We investigated the effect of WGW compared with RW intervention on the fecal microbiota composition and functionality, and correlated intervention-induced changes in bacteria with changes in liver health parameters in adults with overweight or obesity.
We used data of a 12-wk double-blind, randomized, controlled, parallel trial to examine the effects of a WGW (98 g/d) or RW (98 g/d) intervention on the secondary outcomes fecal microbiota composition, predicted microbiota functionality, and stool consistency in 37 women and men (aged 45–70 y, BMI 25–35 kg/m2). The changes in microbiota composition, measured using 16S ribosomal RNA gene sequencing, after a 12-wk intervention were analyzed with nonparametric tests, and correlated with changes in liver fat and circulating concentrations of liver enzymes including alanine transaminase, aspartate transaminase, γ-glutamyltransferase, and serum amyloid A.
The WGW intervention increased the mean (± SD) relative abundances of Ruminococcaceae_UCG-014 (baseline: 2.2 ± 4.6%, differential change over time (Δ) 0.51 ± 4.2%), Ruminiclostridium_9 (baseline: 0.065 ± 0.11%, Δ 0.054 ± 0.14%), and Ruminococcaceae_NK4A214_group (baseline: 0.37 ± 0.56%, Δ 0.17 ± 0.83%), and also the predicted pathway acetyl-CoA fermentation to butyrate II (baseline: 0.23 ± 0.062%, Δ 0.035 ± 0.059%), compared with the RW intervention (P values <0.05). A change in Ruminococcaceae_NK4A214_group was positively correlated with the change in liver fat, in both the WGW (ρ = 0.54; P = 0.026) and RW (ρ = 0.67; P = 0.024) groups.
In middle-aged overweight and obese adults, a 12-wk WGW intervention increased the relative abundance of a number of bacterial taxa from the family Ruminococcaceae and increased predicted fermentation pathways when compared with an RW intervention. Potential protective health effects of replacement of RW by WGW on metabolic organs, such as the liver, via modulation of the microbiota, deserve further investigation.
This trial was registered at clinicaltrials.gov as NCT02385149.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33188417</pmid><doi>10.1093/jn/nxaa312</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-9612-657X</orcidid><orcidid>https://orcid.org/0000-0003-1954-3542</orcidid><orcidid>https://orcid.org/0000-0002-7939-6217</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3166 |
| ispartof | The Journal of nutrition, 2021-03, Vol.151 (3), p.491-502 |
| issn | 0022-3166 1541-6100 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7948209 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Abundance Adults Aged Alanine Alanine transaminase Amyloid Aspartate transaminase Biochemical, Molecular, and Genetic Mechanisms Biomarkers Body weight Composition Correlation analysis Dietary Fiber - administration & dosage Double-Blind Method Fatty liver Fatty Liver - microbiology Fecal microflora Feces Feces - microbiology Female Fermentation Fibers Flour Gastrointestinal Microbiome Gene sequencing gut microbiota human Humans Intervention Intestinal microflora Liver Liver - metabolism Liver - microbiology Liver diseases Male Men Metabolic Networks and Pathways Microbiota Middle Aged Obesity Organs Overweight Overweight - metabolism Overweight - microbiology overweight/obesity refined wheat Relative abundance rRNA 16S Ruminococcaceae Transaminase Wheat whole grain wheat Whole Grains γ-Glutamyltransferase |
| title | Minor Changes in the Composition and Function of the Gut Microbiota During a 12-Week Whole Grain Wheat or Refined Wheat Intervention Correlate with Liver Fat in Overweight and Obese Adults |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T17%3A58%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Minor%20Changes%20in%20the%20Composition%20and%20Function%20of%20the%20Gut%20Microbiota%20During%20a%2012-Week%20Whole%20Grain%20Wheat%20or%20Refined%20Wheat%20Intervention%20Correlate%20with%20Liver%20Fat%20in%20Overweight%20and%20Obese%20Adults&rft.jtitle=The%20Journal%20of%20nutrition&rft.au=van%20Trijp,%20Mara%20P%20H&rft.date=2021-03-01&rft.volume=151&rft.issue=3&rft.spage=491&rft.epage=502&rft.pages=491-502&rft.issn=0022-3166&rft.eissn=1541-6100&rft_id=info:doi/10.1093/jn/nxaa312&rft_dat=%3Cproquest_pubme%3E2509308210%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2509308210&rft_id=info:pmid/33188417&rft_oup_id=10.1093/jn/nxaa312&rft_els_id=S0022316622000608&rfr_iscdi=true |